Soil <Emphasis Type="Italic">Pseudomonas</Emphasis> Community Structure and Its Antagonism Towards <Emphasis Type="Italic">Rhizoctonia solani</Emphasis> Under the Stress of Acetochlor

In a microcosm experiment, the amplified ribosomal DNA restriction analysis was adopted to investigate the Pseudomonas community structure in soils applied with different concentrations (0, 50, 150, and 250 mg/kg) of acetochlor, and an in vitro assay was made to examine the antagonistic activity of isolated Pseudomonas strains acting on soil-borne pathogen Rhizoctonia solani. The results showed that acetochlor application changed the community structure of Pseudomonas in aquic brown soil. The diversity of Pseudomonas and the amount of isolated Pseudomonas strains with antagonistic activity decreased with an increasing acetochlor concentration, and the toxic effect of acetochlor reached to a steady level at 150–250 mg/kg.     

Early experiences from the Kirseberg Public Health Project in Malmo, Sweden An alcohol prevention campaign

This article reports on a pilot demonstration to implement analcohol reduction campaign in the community of Kirseberg (population10 000) located in Malmö, Sweden. Begun in 1988, this publichealth project integrates many aspects of the comprehensivecommunity based models for heart disease and cancer preventionreported in the literature during the past two decades. Utilizinga five stage model of preventive action, the paper details theintervention activities and experiences encountered during theearly phases of community implementation. Overall, the projecthypothesizes a 25% reduction in alcohol use by the year 2000and the prevention of alcohol related problems. The varioustheoretical bases supporting the interventions are discussesedThe role of local organizations and citizen groups activelyinvolved in this partnership strategy is described. Projectobjectives and evaluation plans are presented.     

神经胶质瘤微生态系统研究

恶性神经胶质瘤的生物学行为主要表现为侵袭性生长和高度血管化,这不仅是肿瘤本身的恶性表型,也是神经胶质瘤微生态系统中相关因素相互作用的结果.该文主要介绍神经胶质瘤微生态系统研究状况、与肿瘤微环境的区别、组成要素及血管内皮细胞对其的影响.     

Twenty year smoking trends in a community-based cardiovascular diseases prevention programme: Results from the North Karelia Project

Objectives: to evaluate long-term changes associated with acommunity-based cardiovascular disease prevention programmeon smoking. Methods: the North Karelia Project was started in1972 to carry out a comprehensive community-based programmeto reduce the exceptionally high rates of cardiovascular diseases(CVD) in North Karelia, an eastern province in Finland. Amongthe main intermediate objectives was the reduction of smokingrates, particularly among the male population. The programmewas evaluated by standardized examinations of large representativecross-sectional population samples in 1972, 1977, 1982, 1987and 1992 in North Karelia and in the Kuopio province, anotherprovince in eastern Finland, which was initially chosen as referencearea for the first project period. Results: in men the percentageof current smokers decreased during the 20 years from 52 to32% in North Karelia and from 50 to 37% in the initial referencearea (p<0.05). Smoking declined faster in the first 10 years(from 1972 to 1982) than in the last 10 years. During the first10 years the decline was more remarkable in North Karelia thanin the reference area. The main reason for the decline in smokingduring the first 10 years was smoking cessation and during thelast 10 years the increase in the number of people who had neversmoked regularly. Among women the proportion of smokers increasedin both areas from approximately 10 to approximately 20%. Thisincrease was greatest in the youngest age group. Conclusions:the community-based cardiovascular disease prevention programmewas an effective way to reduce smoking in the general populationin men and sustained decline could be achieved.     

凤庆县艾滋病预防控制与关怀项目效果评估

介绍了凤庆县艾滋病预防控制与关怀合作项目的开展情况，以社区关怀为重点，同时进行不同人群的宣教及行为干预活动及高危人群的STD/HIV检测工作；并总结了项目经验。     

Feasibility, acceptability and cost of home-based HIV testing in rural Kenya

Objective  To demonstrate the feasibility, acceptability and cost of home-based HIV testing and to examine the applicability of the model to high HIV prevalence settings.
Methods  Quantitative, qualitative and cost data were collected during a home-based HIV testing program in a high-prevalence rural area of Kenya; data on age, gender and marital status along with HIV test results were collected. This was complemented with qualitative research including key informant interviews with counselors and program managers to highlight experiences and challenges. Direct costs of the interventions were estimated through the review of budgets and monthly expenditure sheets.
Results  Of 3180 15–49-year olds exposed to a community awareness campaign, 2033 (63.9%) agreed to be visited by counselors, of whom 1984 (97.6%) agreed to be tested and receive the results. Adult HIV prevalence was 8.2% and married women were 4.8 times more likely to be HIV-positive than those never married. Counselors reported feeling welcomed and noted the enthusiasm of the community towards testing. The total cost of the exercise was $17 569. The program cost was $2.60 for each of the 6750 community members, $5.88 for each person tested, and $84 per positive case detected.
Conclusion  This study suggests that home-based HIV testing is feasible with high uptake, and has the potential to substantially expand access to HIV testing services. There is a strong economic case for the extension of such a screening program to other communities.     

Cross-border malaria control for internally displaced persons: observational results from a pilot programme in eastern Burma/Myanmar

Objectives  To document the feasibility of a cross-border community based integrated malaria control programme implemented by internally displaced persons in eastern Burma/Myanmar.
Methods  This pilot study was conducted from February 2003 through January 2005 in seven villages of displaced ethnic Karen. Interventions comprised early diagnosis of Plasmodium falciparum and treatment with mefloquine and artesunate, distribution of long-lasting insecticide treated nets (LLITNs), and educational messages. The primary outcome measure was P. falciparum prevalence during bi-annual universal screenings with the Paracheck-Pf^® (Orchid Biomedical Systems, Goa, India) device. Secondary outcomes were P. falciparum incidence and process indicators related to net use and malaria knowledge, attitudes and practices (KAP).
Results  P. falciparum prevalence in original programme areas declined from 8.4% [95% confidence interval (CI) 8.3–8.6] at baseline to 1.1% (95% CI 1.1–1.2) in the final screening. Annual incidence in original areas declined from 232 to 70 cases/1000/year [incidence rate ratio 0.30 (95% CI 0.24–0.39)]. The proportion of household members sleeping under a LLITN improved from 0% to 89% and malaria KAP improved in all areas.
Conclusions  Integrated malaria control organized and implemented by displaced persons is feasible in eastern Burma/Myanmar. The decline in P. falciparum prevalence and incidence suggest that it may be possible to reduce the burden of disease and the reservoir of malaria in eastern Burma/Myanmar, with implications for malaria control in the greater Mekong region.     

Experiences of disability consumer-directed care users in Australia: results from a longitudinal qualitative study

The rapidly growing body of literature suggests that Consumer-directed Care (CDC) has the potential to empower consumers and improve the flexibility and quality of care. However, reports highlighting quality and risk concerns associated with CDC focusing on a longer time frame have been few. This paper presents the findings from a qualitative longitudinal evaluation of an Australian CDC programme. Focusing on the period between 2003 and 2008, it reports on the experiences of 12 families caring for a dependent family member. It is based on two external evaluations completed 6 and 36 months after enrolment, and one internal evaluation completed 48 months after enrolment. The findings were triangulated with internal memos, reports and minutes of meetings, as well as with the theoretical literature. The study demonstrates that CDC harbours considerable benefits for people with disabilities and their carers. However, the study also suggests that, over time, carers may experience an increased sense of isolation and lack of support as a result of their involvement in the CDC programme. The paper argues that the development of safeguards addressing these weaknesses is crucial for the sustainability of CDC programmes in contexts where risk cannot be simply transferred onto consumers.     

Introducing community mental health services. The effects on a suburban patient population

By means of a computerised psychiatric case register, the effects on a defined population with 71,371 inhabitants were studied when the mainly hospital-based psychiatric services in the area were changed to community mental health units with substantial outpatient resources. Diagnostic, social and demographic variables and care utilisation rates were compared. A 29% increase in patients under the new system was observed. Most of the newcomers had acute crisis reactions, were younger, on average, than previous patients and registered alcohol abuse and somatic diseases. Outpatient utilisation increased (170%) and hospital admissions decreased (22%). Compulsory admissions increased (43%), as did sick-leave registrations (21%). These trends are discussed in light of the new organization.