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P. J. N. Bloem L. M. G. C. Goessens P. Zamparo M. Sacher R. Paviotti P. E. di Prampero 《European journal of applied physiology》1991,62(3):204-210
Summary Thirteen male subjects performed a running test on the treadmill consisting of four standard exercise intensities [65%, 75%, 85%, 95% maximal O2 uptake (VO2max)] presented in ascending, descending or random order. At the end of each exercise intensity, O2 consumption, heart rate (f
c), venous blood lactate concentration ([la]b) and perceived exertion were assessed. This last variable was determined according to the Borg nonlinear CR-20 scale. The same variables were also determined during exercise at a standard intensity (65% or 95%VO2max) performed before and after a Finnish sauna bath. Ratings of perceived exertion showed a good test-retest reliability (r=0.77); they were the same when the exercise intensity was expressed in relative (%VO2max) or absolute (speed) terms, and were independent of the order of presentation of the exercise. The latter had no effect onf
c either but it did, however, influence [la]b, which was significantly higher in the descending, as compared to the ascending or random modes of presentation. The sauna bath increasedf
c at a given exercise intensity, but left perceived exertion and [la]b unchanged. It was concluded that at least under the present experimental conditions,f
c and venous [la]b do not play a major role as determinants of perceived exertion. 相似文献
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玉津药酒治疗类风湿性关节炎的临床观察 总被引:1,自引:0,他引:1
笔者应用复方玉津药酒对120例类风湿性关节炎(RA)患者进行了临床治疗效果观察.结果表明,近期控制为54.2%,显效为29.2%,有效为13.3%,无效为3.3%;经免疫学检查,玉津药酒可促使CD_8细胞增高,改善CD_4/CD_8比值,抑制T淋巴细胞增殖,降低白细胞介素-2(IL-2)活性,从而抑制机体免疫活性细胞对关节、关节软骨的破坏作用. 相似文献
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In urology, replacement of organs or organ segments has proved problematic. Current techniques do not replicate complete
organ function, and they cause well-known complications. With the acellular organ-specific matrix we have found a way to regenerate
tissue components seen in the normal lower urinary tract. The time required for regeneration depends on the matrix size and
function. The matrix is covered by urothelium migrating from the host, after which neovascularization occurs, followed by
formation of smooth-muscle cells and nerves. In our studies, normal muscle lining and nerves providing functional tissue were
demonstrable and no sign of antigenicity was evident, even after heterologous grafting. The regenerated rat bladder was evaluated
by organ bath as well as by in vivo functional tests and demonstrated properties and functions similar to those of host tissue.
Besides our obtaining encouraging results in the rat bladder, we also studied the organ-specific acellular matrix in other
species (dog and rabbit) and other organ segments (ureter and urethra). 相似文献
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目的:探讨羌活鱼水提物含药血清对大鼠骨髓间充质细胞(BMSCs)成骨的作用。方法:取大鼠第三代BMSCs分为4组,待BMSCs接近80%融合时,分别应用生理盐水+DMEM/F12培养液+成骨分化诱导液+5%FBS(生理盐水对照组)、高剂量羌活鱼水提物+DMEM/F12培养液+成骨分化诱导液+5%FBS(羌活鱼水提物高剂量组)、中剂量羌活鱼水提物+DMEM/F12培养液+成骨分化诱导液+5%FBS(羌活鱼水提物中剂量组)、低剂量羌活鱼水提物+DMEM/F12培养液+成骨分化诱导液+5%FBS(羌活鱼水提物低剂量组)培养基培养。应用碱性磷酸酶(ALP)活性、钙盐沉积量及钙化结节数检测成骨分化程度。采用SPSS 16.0软件包对数据进行单因素方差分析。结果:羌活鱼水提物含药血清组较生理盐水对照组表现出高ALP活性、高钙盐沉积量、高骨钙素分泌量。结论:羌活鱼水提物含药血清可提高成骨性诱导液诱导BMSCs成骨分化的能力,表现出高ALP活性及基质矿化能力,在BMSCs成骨分化中可起到重要作用。 相似文献
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观察不同低氧时段下,原代大鼠肺动脉平滑肌细胞(pulmonary arterial smooth muscle cells,PASMCs)ATP敏感性钾通道(ATP-sensitive potassium channel,K_(ATP)通道)蛋白的表达,探讨芪白平肺胶囊含药血清(简称QBPF)调控PASMCs K_(ATP)通道蛋白表达与一氧化氮(nitric oxide,NO)的相关性。清洁级SD大鼠给予芪白平肺胶囊颗粒连续灌胃10 d,制备芪白平肺含药血清。采用组织块贴壁法,体外培养原代大鼠肺动脉平滑肌细胞;Western blot检测不同低氧时间下Kir6.1和SUR2B的表达,以及在一氧化氮合酶抑制剂——Nω-硝基-L-精氨酸甲酯(Nω-nitro-L-arginine methyl ester,L-NAME)和K_(ATP)通道抑制剂——格列本脲(glyburide,GLYB)分别干预下,QBPF对其表达的影响。低氧6 h后Kir6.1和SUR2B蛋白表达开始上调,在低氧24 h达到高峰,低氧48,72 h的蛋白表达出现不同程度下调。在低氧24 h条件下,QBPF能进一步上调K_(ATP)通道Kir6.1和SUR2B蛋白表达,且这种上调作用能分别被K_(ATP)通道阻断剂GLYB和NO特异性阻断剂L-NAME所阻断,提示芪白平肺胶囊具有明确的K_(ATP)通道开放作用,其机制可能通过介导NO相关途径上调K_(ATP)通道蛋白表达,参与肺血管舒张作用,缓解COPD的发生发展。 相似文献