全文获取类型
收费全文 | 182584篇 |
免费 | 16708篇 |
国内免费 | 8229篇 |
专业分类
耳鼻咽喉 | 2328篇 |
儿科学 | 4200篇 |
妇产科学 | 1992篇 |
基础医学 | 31799篇 |
口腔科学 | 5565篇 |
临床医学 | 14462篇 |
内科学 | 25070篇 |
皮肤病学 | 4589篇 |
神经病学 | 10151篇 |
特种医学 | 4158篇 |
外国民族医学 | 119篇 |
外科学 | 15367篇 |
综合类 | 27563篇 |
现状与发展 | 48篇 |
预防医学 | 5926篇 |
眼科学 | 3782篇 |
药学 | 17353篇 |
39篇 | |
中国医学 | 5827篇 |
肿瘤学 | 27183篇 |
出版年
2024年 | 316篇 |
2023年 | 2602篇 |
2022年 | 4302篇 |
2021年 | 6696篇 |
2020年 | 5890篇 |
2019年 | 5813篇 |
2018年 | 5972篇 |
2017年 | 6205篇 |
2016年 | 6419篇 |
2015年 | 7206篇 |
2014年 | 10848篇 |
2013年 | 12002篇 |
2012年 | 10391篇 |
2011年 | 11664篇 |
2010年 | 9571篇 |
2009年 | 9115篇 |
2008年 | 9599篇 |
2007年 | 9840篇 |
2006年 | 8812篇 |
2005年 | 8139篇 |
2004年 | 7248篇 |
2003年 | 6249篇 |
2002年 | 5115篇 |
2001年 | 4378篇 |
2000年 | 3674篇 |
1999年 | 3304篇 |
1998年 | 3090篇 |
1997年 | 2861篇 |
1996年 | 2537篇 |
1995年 | 2258篇 |
1994年 | 1996篇 |
1993年 | 1658篇 |
1992年 | 1375篇 |
1991年 | 1300篇 |
1990年 | 1039篇 |
1989年 | 941篇 |
1988年 | 904篇 |
1987年 | 707篇 |
1986年 | 669篇 |
1985年 | 892篇 |
1984年 | 786篇 |
1983年 | 545篇 |
1982年 | 589篇 |
1981年 | 468篇 |
1980年 | 408篇 |
1979年 | 324篇 |
1978年 | 217篇 |
1977年 | 199篇 |
1976年 | 136篇 |
1975年 | 61篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
921.
Alexander Goldberg Ursula Schlötzer-Schrehardt Theo Seiler 《International ophthalmology》1997,21(3):117-120
We report the first case of a unilateral microcysticMeesmann‘s epithelial dystrophy, observed in the left cornea of a 43-year-old
patient. The diagnosis was verified histologically by the unilateral occurrence of a ’peculiar substance‘ within epithelial
cysts and within the cytoplasm of the corneal epithelial cells. In an attempt to resolve thepatient‘s frequent corneal erosions,
we performed an autologous stem cell transplantation from the non-involved right eye. The results are, so far, satisfactory.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
922.
G TamizhMani J.P Dodelet D Guay L Dignard-Bailey 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》1998,444(1):121-125
Four platinum-based catalysts with different catalytic activity for the oxygen reduction reaction have been prepared and tested in polymer fuel cells (PFCs) and in half-cells with H2SO4 and HF electrolytes. The activity results of PFCs at 0.9 V versus RHE (reversible hydrogen electrode) can be mimicked in parallel by the results obtained in HF electrolyte but not by the results obtained in H2SO4 electrolyte. This paper concludes that the pre-screening of a huge number of Pt-based catalysts for the selection of potential catalysts for the PFCs can be carried out by a rapid half-cell technique with a non-adsorbing electrolyte such as HF. 相似文献
923.
The complexity of the RHD and RHCE genes, which is the greatest of all blood group systems, confounds analysis at the molecular level. RH DNA typing was introduced in 1993 and has been applied to prenatal testing. PCR-SSP analysis covering multiple polymorphisms was recently introduced for the screening and initial characterization of partial D. Our objective is to summarize the accrued knowledge relevant to the approaches to Rh phenotype prediction by DNA typing, their possible applications beyond research laboratories and their limitations. The procedures, results and problems encountered are highly detailed. It is recommended that DNA typing comprises an analysis of more than one polymorphism. We discuss future directions and propose a piecemeal approach to improve reliability and cost-efficiency of blood group genotyping that may eventually replace the prevalent serology-based techniques even for many routine tasks. Transfusion medicine is in the unique position of being able to utilize the most extensive phenotype databases available to check and develop genotyping strategies. 相似文献
924.
Takashi Takata Yong Lu Ikuko Ogawa Ming Zhao Zhi Yu Zhou David Mock Hiromasa Nikai 《Pathology international》1998,48(11):877-881
The calcifying odontogenic cyst (COC) presents with diverse hlstologlcal features; thus, several subclasslfl-cations have been proposed. To evaluate the slgnlficance of the various histological features and subtypes of COC from the perspectlve of proliferative activity, the proliferating cell nuclear antigen (PCNA) labellng index (LI; the percentage of positive nuclei) was assessed immunohistochemlcally in 25 cases of COC (21 benign and four malignant). All of the benign cases were of the cystic variety and further subclas-sified into non-proliferative subtype (NPS; four cases); proliferative subtype (PS; eight cases); and COC associated with odontoma (COCaO, nlne cases). The PCNA U of the mallgnant COC (65.2 ± 5.6) was slgnlflcantly higher than that of the benlgn COC (11.6 ± 9.0; P = 0.002). Non-proliferative subtype (6.8 ± 2.8) showed the lowest PCNA LI and PS (17.2 ± 11.2) the highest of among the three subtypes of benign cystic COC (P = 0.028). In nine cases of COCaO, six showed epithelial lining of the non-proliferative type as NPS and the other three had lining wlth proliferative features as PS. The PCNA LI of the latter COCaO group (14.3 ± 6.6) was significantly higher than that of the former (6.1 ± 4.3; P = 0.05), as Seen between PS and NPS. These results demonstrate that PCNA LI is a possible parameter for differentiating mallgnant COC from benign COC and, whatever the subtypes, the proliferative features In the lining are the main factor influencing the prollferatlng actlvity of COC. 相似文献
925.
926.
4背景
近年,成人急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)诱导完全缓解(complete remission,CR)率可达80%~85%.5年无病生存率(diseases-free survival,DFS)30%-40%。成人ALL预后的改善可能与采用了包括以大剂量甲氨蝶呤联合阿糖胞苷的强烈巩固治疗方案有关.并与根据疾病危险度进行分级分层治疗、根据疾病亚型制定个体化的治疗方案有关。 相似文献
927.
人冠状病毒72-62和73-50干燥毒种,用人胚器官和原代人胚肾细胞合管培养未能引起细胞病变,而将病毒液接种到人胚器官细胞或人胚肺传代细胞第一代就能引起明显的细胞病变。新传代病毒经电镜及中和试验鉴定确属人冠状病毒。实验结果证明人胚肺传代细胞比原代人胚肾细胞敏感,为进一步研究人冠状病毒提供了一株敏感的细胞。 相似文献
928.
应用~(51)Cr释放试验和效靶结合试验,同时测定了正常人和胃癌病人外周血NK细胞活性与靶结合细胞数(TBC),研究了正常人及病人血浆对NK细胞功能的影响。发现正常人NK细胞活性与靶结合细胞数之间的关系呈直线正相关,但在NK活性降低的病人中靶结合细胞数却无明显改变,二者无相关性,而病人的血浆对正常人外周血NK活性则有明显的抑制作用(P<0.05),且抑制率与胃癌人NK细胞活性存有着负相关的关系,提示胃癌病人血浆具有抑制NK细胞活性的物质。 相似文献
929.
辛伐他汀对CD40L介导的ECV-304细胞E选择素表达及粘附功能的影响 总被引:2,自引:0,他引:2
目的研究在人脐静脉内皮细胞中3-羟-3-甲基戊二酰辅酶A(HMG-CoA)还原酶对CD40/CD40L系统介导的粘附分子表达的影响,及对淋巴细胞与内皮细胞的粘附功能的影响。方法采用人脐静脉内皮细胞株ECV-304,CD40L干预,使之与其表面的CD40作用,用不同浓度辛伐他汀或辛伐他汀(5μmol.L-1)+甲羟戊酸干预,流式细胞术和RT-PCR检测干预前后E选择素(E-Selectin)的表达,流式细胞术检测CD40L介导的淋巴细胞与内皮细胞的粘附功能。结果不同浓度辛伐他汀可下调CD40L介导的E-Selectin的表达,并呈一定的剂量依赖性。甲羟戊酸(400μmol.L-1)抑制了辛伐他汀(5μmol.L-1)对E-Selectin表达的下调作用。辛伐他汀可降低CD40L介导的淋巴细胞与内皮细胞的粘附功能。结论他汀类药物的抗炎作用与抑制CD40-CD40L系统有关,其机制是通过抑制HMG-CoA还原酶而发挥作用的。 相似文献
930.
本文将Rowland等人的二房室模型中的消除过程扩展成米氏兼一级消除过程。据此,推导出达到稳态浓度的时间、血药浓度-时间曲线下面积和生物利用度的公式;进而得到平均清除率和剂量间的关系以及剂量与平均清除率和血浆浓度呈线性关系的结论。 相似文献