Matching Special Olympics registration data with administrative health databases: Feasibility and health status differences in children and youth with IDD

BackgroundChildren and youth with intellectual and developmental disabilities (IDD) experience health disparities. What is unknown is if data collected from children and youth with IDD who participate in Special Olympics is representative of children and youth with IDD who do not.ObjectivesAim 1: determine the feasibility of matching a database of registrants from Special Olympics Ontario (SOO), with population-based health services databases in Ontario, Canada housed at ICES. Aim 2: evaluate the differences between the database sources with regards to demographic variables and clinical status.MethodsUsing deterministic and probabilistic matching, registration data from SOO were matched to administrative health databases. Established algorithms were used to determine the prevalence of asthma, diabetes, and mental disorder in addition to demographic variables.ResultsThe matching rate was over 90%; 8404 were attributed to children and youth between the ages of 0–19 years. When comparing SOO participants with IDD to non-SOO participants with IDD, children and youth who participate in SOO were, on average, older with no further differences between groups on clinical or demographic variables. When comparing those previously not identified in the health services databases (from SOO) to those with IDD identified by ICES, the SOO participants appear to use the health system less, possibly indicating a better health status.ConclusionsResearch conducted on child and youth who participate in Special Olympics Ontario can be generalized to the broader population of children and youth with IDD in Canada when adjusted for age; however, care should be taken when comparing levels of overall morbidity.     

The association between metabolic syndrome and lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males: evidence based on propensity score matching

BackgroundTo investigate the association between lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and metabolic syndrome (MetS) in aging Chinese males.MethodsA dataset that included 3,568 non-MetS cases and 1,020 MetS cases (after data cleansing) was downloaded from the China Health and Retirement Longitudinal Study (CHARLS). To balance the intergroup covariates, propensity score matching (PSM) was employed in the analyses. Univariate logistic regression and multivariate logistic regression were then performed to investigate the relationship between LUTS/BPH and MetS in aging Chinese males.ResultsBefore PSM, multivariate logistic regression showed that participants with MetS had a 1.47 times higher risk of LUTS/BPH compared to non-MetS cases in the final model (P<0.001). It also revealed that participants with low high-density lipoprotein (HDL), abdominal adiposity, or high triglycerides had a higher probability of LUTS/BPH [odds ratio (OR) =1.56 for low HDL; OR =1.50 for abdominal adiposity; and OR =1.48 for high triglyceride, P<0.001], while participants with hyperglycemia or hypertension had identical odds of LUTS/BPH (P>0.05). After PSM, 1,000 pairs were successfully matched. It was also found that MetS cases had a 1.60 times higher risk of LUTS/BPH compared to non-MetS cases (P<0.001), and participants with low HDL, abdominal adiposity, high triglycerides, or hyperglycemia had a higher likelihood of LUTS/BPH than their counterparts (P<0.001). However, the probability of LUTS/BPH in hypertensive patients remained similar to that in non-hypertensive patients (P>0.05).ConclusionsAging Chinese males with MetS had a higher probability of LUTS/BPH. Also, patients with low HDL, abdominal obesity, high triglycerides, or hyperglycemia had an increased risk of LUTS/BPH; however, this was not the case for hypertensive patients.     

基于倾向性匹配法的胆囊结石合并慢性胆囊炎手术DRG控费效果研究

目的 基于倾向性匹配分析疾病诊断相关分组（DRG）对胆囊结石合并慢性胆囊炎手术患者住院费用的控费效果。方法 收集2021年1月至2022年12月安徽医科大学第一附属医院1 010例胆囊结石合并慢性胆囊炎手术患者住院费用数据,按付费方式分为DRG组（n=570）和非DRG组（n=440）。采用描述性统计分析、倾向性评分法、秩和检验,平衡病例间混杂因素后,检验DRG组和非DRG组住院费用情况。结果 共纳入1 010例病例,经倾向性匹配成功852例。胆囊结石合并慢性胆囊炎患者DRG组与非DRG组年龄、住院天数在匹配前差异有统计学意义（P<0.05）。患者住院费用中,耗材费、药费占比较高。经倾向性匹配后,DRG组与非DRG组住院总费用（Z=7.519,P<0.001）、自费金额（Z=13.903,P<0.001）、医保报销费用（Z=11.561,P<0.001）、综合医疗服务费（Z=2.188,P=0.029）、手术费（Z=2.256,P=0.024）、药费（Z=3.202,P=0.001）、耗材费（Z=2.229,P=0.026）、诊断费（Z=8.263,P<0.001）差异均有统计学意义。结论 DRG对胆囊结石合并慢性胆囊炎患者自费金额、综合医疗服务费、手术费、药费、耗材费及诊断费均具有控费效果,且总体对住院费用控费效果较好,但费用结构方面仍存在优化空间。     

肾移植病人配组淋巴细胞毒抗体的检测

目的：通过对肾移植病人的配组淋巴细胞毒抗体（ｐａｎｅｌ ｒｅａｃｔｉｖｅ ａｎｔｉｂｏｄｙ ＰＲＡ）的检测,了解与分析肾移植病人配组淋巴细胞毒抗体的差异。方法：以３６名健康成人外周血淋巴细胞作为群体淋巴细胞来源,采用补体依赖微量淋巴细胞毒方法,检测病人血清中的配组淋巴细胞毒抗体。结果：５５例病人进行血清淋巴细胞毒交叉配合实验检测,只有１例阳性１．８２％。而ＰＲＡ检测８例病人血清为阳性（６女２男）占     

Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: opposite effects of FG 7142 and lorazepam

The effects of a series of benzodiazepine (BZ) receptor ligands, ranging from a full agonist through to partial inverse agonists, were examined on short term working memory in the rat. The behavioural paradigm used was a discrete trial, operant delayed matching to position task, as originally described by Dunnett (1985), with delays of 0, 5, 15 and 30 s. The benzodiazepine receptor (BZR) full agonist lorazepam (0.25, 0.375 and 0.5 mg/kg) dose and delay dependently impaired matching accuracy. Lorazepam also increased the latency to respond and decreased the number of nose pokes made into the food tray during the delays. In contrast, the BZR partial agonist ZK 95 962 (1, 3, 10 mg/kg) did not affect matching accuracy, but did increase the speed of responding. The BZR antagonist ZK 93 426 (1.25, 5, 25 mg/kg) had no effects in this paradigm. The BZR weak partial inverse agonists Ro 15-4513 (0.1, 1 and 10 mg/kg) and ZK 90 886 (1, 3 and 10 mg/kg) did not affect accuracy of performance. However, both of these drugs increased the latency to respond and decreased nose poke responses. These motoric effects were particularly strong following 10 mg/kg Ro 15-4513. This shows that the effects of drugs on the accuracy of responding and on the speed of responding can be dissociated. The BZR partial inverse agonist FG 7142 had effects on matching accuracy that were dependent upon dose. The lowest dose of FG 7142 (1 mg/kg) significantly improved accuracy, whereas the highest dose (10 mg/kg) impaired accuracy. This impairment induced by FG 7142 (10 mg/kg) was accompanied by an increase in the latency to respond and a decrease in the number of nose pokes. Taken together, these results show that the accuracy of delayed matching performance can be modulated in opposite ways by the BZR full agonist lorazepam and a low dose of the BZR partial inverse agonist, FG 7142.     

血库在安全输血中的重要性

为了全面发展安全输血事业，除了血液中心或血站与此有非常重要的关系外，血库也是一个极其重要的环节。本文从配血样本的严格把关；技术操作的规范化；科学合理用血；记录与核对；输血前的病毒检验几术方面阐述了安全血液与血库的关系，强调血库的重要性，以全方位保证临床输血安全。     

室性早搏的快速检测方法

提出一种利用相关性和RR间期比相结合的快速室性早搏的检测算法.该算法具有一定的病人自适应性.通过MIT-BIH心律失常数据库的验证,该方法对Normal和PVC有很高的识别率.     

肾移植组织配型管理软件的研究与开发思路

目的 开发肾移植组织配型管理软件并观察其临床实用性。方法 参考氨基酸残基配型及致敏性错配制定配型标准，采用Powerbuild系统编制同种异体肾移植组织配型管理软件，观察肾移植术前快速组织配型分析的可行性。结果 从筛选最佳供受者到列表打印结果仅需数分钟，历史数据可查询，界面简单，结果准确、可靠。配型标准可自行更改。结论 经国内8家移植中心使用，证明该软件设计科学合理，操作简便，运行稳定，实用性强，具有一定的推广价值。     

Health-related risk behaviors among myocardial infarction survivors in the United States: A propensity score matched study

BackgroundAccording to the American College of Cardiology/the American Heart Association (ACC/AHA) recommendations, health-related risk behaviors for secondary prevention of myocardial infarction (MI) are critical to determine.ObjectiveThis study aimed to compare health-related risk behaviors between MI survivors and propensity-score-matched non-MI controls using nationally representative data.MethodsThis cross-sectional, matched case-control study used publicly available Behavioral Risk Factor Surveillance System (BRFSS) 2017 data. Older adults with MI were propensity-score-matched to their non-MI controls. The 10 dependent variables included body mass index (BMI), smoking status, heavy alcohol consumption, influenza vaccine, length of time since last routine and cholesterol checkup, alcohol consumption, fruit and vegetable consumption, and physical activity. Chi-square tests and binomial logistic regression were used to examine the health-related risk behaviors differences between MI survivors and propensity-score-matched non-MI controls.ResultsThe final study sample consisted of 18,021 MI survivors and 54,063 non-MI controls after propensity score matching. Multivariable logistic regression analysis showed significant differences between MI survivors and matched non-MI controls in terms of cholesterol checkup, smoking status, and alcohol consumption. For example, multivariate analysis of health-related risk behaviors showed MI survivors were more likely to be smokers (AOR = 1.46, 95% CI: 1.28–1.68).ConclusionBased on this national survey of adults, MI survivors were more likely to be smokers but less likely to consume alcohol compared to their propensity-score-matched controls. Moreover, MI survivors were more likely to have their cholesterol checkup within the past 2 years compared to matched non-MI controls. Although lower alcohol consumption and greater chances of cholesterol checkups are reassuring health-related behaviors, interventions are needed to minimize the chances of smoking in this population.