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71.
神经精神性红斑狼疮的脑部MRI表现 总被引:1,自引:0,他引:1
目的 分析神经精神性红斑狼疮(NP-SLE)的脑部MRI表现,探讨MRI对NP-SLE的诊断价值.方法 收集2000年1月~2005年4月符合NP-SLE临床诊断标准病例13例,均为女性,年龄10~40岁,平均30岁,病程30天~25年.采用Simens Impact 1.0T MR成像仪,SE序列行轴位T1WI、T2WI、矢状位T2WI及增强扫描,分析其脑部MRI表现.结果 13例20次MRI检查均有异常,阳性率为100%,表现为点状、斑片状长T1长T2异常信号,主要分布在大脑皮层、层下白质及基底节区,病灶周围无水肿,占位效应不明显.2例增强扫描病灶呈不规则强化,7例有脑萎缩.结论 MRI对NP-SLE脑部病变有较高的价值,但作出NP-SLE诊断需结合临床和实验室检查. 相似文献
72.
动态观察实验性糖尿病大鼠于发病后2、4、6、12、和16周肾脏损害指标和肾脏脂质过氧化物(LPO)水平的变化。结果表明,发病后各观察时间.或糖尿病大鼠24h尿Alb、β2──MG排泄量和尿NAG活性均明显增高,而24h尿THP排泄量显著降低,肾脏LPO水平明显升高。其中尿NAG活性、THP排泄量和肾脏LPO水平均随病程延长而更趋明显。这些结果提示,在糖尿病早期除有肾小球功能损害外,肾小管也明显受损,过氧化损伤在糖尿病肾病发病中可能是重要因素之一。尿Alb、β2──MG、THP含量和NAG活性可作为糖尿病肾病早期肾损害的敏感指标。 相似文献
73.
Hideo Kanauchi Sadao Imamura Masahiro Takigawa Fukumi Furukawa 《The Journal of dermatology》1994,21(12):935-939
Kampo, a Japanese-Chinese traditional herbal medicine, has been used for the treatment of various diseases for about 3,000 years in China. Among herbal medicines, Sairei-to is well known for improving the symptoms of rheumatoid arthritis (RA) and other collagen diseases. However, its immunosuppressive effects on autoimmune cutaneous phenomena are not completely understood. We investigated the effects of Sairei-to on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice, an animal model which spontaneously develops skin lesions similar to those seen in human lupus erythematosus. Virgin female MRL/lpr mice at 1 month of age, which were treated orally with Sairei-to, had reduced amounts of IgG deposition at the dermoepidermal junction, titers of anti-DNA antibodies and rheumatoid factor, and lymphoproliferation. These results support the use of traditional herbal medicines in patients with human RA and systemic lupus erythematosus. 相似文献
74.
C. Lefaucheur G. S. Hill C. Amrein J.-P. Haymann C. Jacquot D. Glotz D. Nochy 《American journal of transplantation》2006,6(10):2516-2521
Acute renal insufficiency (ARI) is a frequent complication of nonrenal solid organ transplantation and may be responsible for an unfavorable outcome, particularly if dialysis is required. The etiology of post-transplantation ARI is poorly understood, with only isolated clinical cases being reported, most imputed to drug toxicity. We report here, the first three observations of irreversible ARI associated with acute oxalate nephropathy (AON) in the course of nonrenal organ transplants: a lung transplant and a lung-liver transplant in two patients with mucoviscidosis, and a cardiac transplant. The diagnosis of AON was made histologically. In all three cases, the ARI supervened after prolonged consumption of antibiotics capable of interfering with the colonic flora, and leading to enteric hyperoxaluria. The recognition of AON as a cause of post-transplantation, ARI underlines hyperoxaluria and digestive hyperabsorption of oxalate as specific risk factors for AON and should permit better posttransplant care of these patients. 相似文献
75.
2型糖尿病肾病患者血清中TNF-α、NO与ET的水平变化及其临床意义 总被引:1,自引:0,他引:1
目的:探讨2型糖尿病肾病患者血清肿瘤坏死因子仅(TNF-α)、一氧化氮(NO)和内皮素(ET)的水平变化及其临床意义。方法:用ELISA法检测91例2型糖尿病患者血清TNF-α水平,NO与ET的水平分别用硝酸还原酶法和放射免疫法测定。结果:2型糖尿病肾病各组患者TNF-α和ET水平较对照组明显升高,其中ODN组最高(P〈0.01)。而2型糖尿病肾病各组患者血清NO水平较对照组明显减少(P〈0.01)。显性糖尿病肾病患者血清TNF-α和ET呈正相关;血清TNF-α和NO、ET和NO均成负相关。结论:TNF-α、NO与ET可能参与2型糖尿病肾病的发病及病程变化过程,检测患者TNF-α、NO与ET水平可作为判断预后、指导治疗的指标。 相似文献
76.
糖尿病大鼠肾组织中单核细胞趋化蛋白-1的表达及意义 总被引:2,自引:1,他引:1
目的:探讨单核细胞趋化蛋白-1(MCP—1)在糖尿病大鼠肾组织中的表达及其意义。方法:用链脲佐菌素制备糖尿病大鼠模型。采用免疫组化及多媒体彩色病理图文分析系统观察肾小球及肾小管中MCP-1的表达。结果:糖尿病大鼠肾小球及肾小管中MCP—1的表达显著上调。结论:MCP-1在糖尿病肾病发病机制中发挥重要作用。 相似文献
77.
Mary M. Klote Lawrence Y. Agodoa Kevin Abbott 《American journal of transplantation》2004,4(9):1523-1528
The incidence, risk factors, and prognosis for Mycobacterium tuberculosis (MTB) infection have not been reported in a national population of renal transplant recipients. We performed a retrospective cohort study of 15,870 Medicare patients who received renal transplants from January 1, 1998 to July 31, 2000. Cox regression analysis derived adjusted hazard ratios (AHR) for factors associated with a diagnosis of MTB infection (by Medicare Institutional Claims) and the association of MTB infection with survival. There were 66 renal transplant recipients diagnosed with tuberculosis infection after transplant (2.5 cases per 1000 person years at risk, with some falling off of cases over time). The most common diagnosis was pulmonary TB (41 cases). In Cox regression analysis, only systemic lupus erythematosus (SLE) was independently associated with TB. Mortality after TB was diagnosed was 23% at 1 year, which was significantly higher than in renal transplant recipients without TB (AHR, 4.13, 95% CI, 2.21, 7.71, p < 0.001). Although uncommon, MTB infection is associated with a substantially increased risk of mortality after renal transplantation. High-risk groups, particularly those with SLE prior to transplant, might benefit from intensified screening. 相似文献
78.
目的 :探讨氧化反应对糖尿病大鼠造影剂肾病发生的影响。方法 :建立SD大鼠糖尿病动物模型 ,8w后分 3组 :正常对照组 (SD组 )、糖尿病对照组 (DM组 )和糖尿病 +造影剂组 (CM组 )。其中CM组大鼠经尾静脉一次性注入 76%泛影葡胺 ( 10ml/kg体重 ,3gI(iodine) /10ml) ,DM组注射等量生理盐水。 3d后收集血标本检测血肌酐、血尿素氮 ;取肾脏组织 ,测定肾组织丙二醛 (MDA)与超氧化物歧化酶 (SOD)的含量。结果 :与正常对照组相比 ,糖尿病组 (DM组 )的MDA含量与SOD活性均明显升高 (P <0 .0 5 ) ;糖尿病大鼠注射造影剂 (CM组 ) 3d后MDA含量明显增加 ,SOD活性明显降低 ,与DM组差异有显著性 (P <0 .0 5 )。结论 :糖尿病大鼠造影剂肾病发生时 ,肾脏组织产生过氧化物增多、清除能力下降 ,提示氧化反应对糖尿病造影剂肾病的发生起一定作用 相似文献
79.
TOMOHITO GOHDA MITSUO TANIMOTO KAORI WATANABE-YAMADA MASAKAZU MATSUMOTO SHIGERU KANEKO SHINJI HAGIWARA KENJI SHIINA TOSHIHIDE SHIKE KAZUHIKO FUNABIKI YASUHIKO TOMINO 《Nephrology (Carlton, Vic.)》2005,10(S2):S22-S25
SUMMARY: Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) in Japan, Western Europe, and the United States. Mega studies such as Diabetes Control and Complication Trial (DCCT), Epidemiology of Diabetes Interventions and Complications (EDIC), and the United Kingdom Prospective Diabetes Study (UKPDS) clarified that poor glycemic and blood pressure control are undoubtedly involved in the development of nephropathy. However, these factors are not sufficient to predict which diabetic patients will develop renal disease, because not all patients with poor glycemic and blood pressure control develop renal disease. Since ethnic variations and familial clustering of diabetic nephropathy have been observed, genetic factors might contribute to susceptibility to this disease. Several methods such as (genome wide) association studies, sib-pair analysis, and quantitative trait loci (QTLs) analysis are available to examine polygenic diseases. However, no mutations that could explain the majority of nephropathy cases have been identified so far. The development of most diabetic nephropathy might be explained by the polygenic effect (i.e. many minor gene-gene interactions might be very important in the development of nephropathy). Identification of candidate genes of nephropathy enables targeting of therapy in patients at risk and development of novel therapeutic agents. 相似文献
80.
Antibody Response Against the Glomerular Basement Membrane Protein Agrin in Patients with Transplant Glomerulopathy 总被引:3,自引:0,他引:3
Simone A. Joosten Yvo W.J. Sijpkens Vanessa van Ham Leendert A. Trouw Johan van der Vlag Bert van den Heuvel Cees van Kooten Leendert C. Paul 《American journal of transplantation》2005,5(2):383-393
Chronic allograft nephropathy (CAN) of renal allografts is still the most important cause of graft loss. A subset of these patients have transplant glomerulopathy (TGP), characterized by glomerular basement membrane (GBM) duplications, but of unknown etiology. Recently, a role for the immune system in the pathogenesis of TGP has been suggested. In 11 of 16 patients with TGP and in 3 of 16 controls with CAN in the absence of TGP we demonstrate circulating antibodies reactive with GBM isolates. The presence of anti-GBM antibodies was associated with the number of rejection episodes prior to diagnosis of TGP. Sera from the TGP patients also reacted with highly purified GBM heparan sulphate proteoglycans (HSPG). Indirect immunofluorescence with patient IgG showed a GBM-like staining pattern and colocalization with the HSPGs perlecan and especially agrin. Using patient IgG, we affinity purified the antigen and identified it as agrin. Reactivity with agrin was found in 7 of 16 (44%) of patients with TGP and in 7 of 11 (64%) patients with anti-GBM reactivity. In conclusion, we have identified a humoral response against the GBM-HSPG agrin in patients with TGP, which may play a role in the pathogenesis of TGP. 相似文献