Addition of a gonadotropin releasing hormone (GnRH) antagonist and exogenous gonadotropins to unstimulated in vitro fertilization (IVF) cycles: Physiologic observations and preliminary experience

Purpose To describe our preliminary experience with the addition of a GnRH antagonist (Nal-Glu) and exogenous gonadotropins (follicle stimulating hormone; FSH) to unstimulated IVF cycles.Method Seven spontaneously ovulatory women underwent eight unstimulated IVF cycles at our institution. They were treated with a single dose of Nal-Glu, 50 g/ kg, or with a combination of Nal-Glu, 50 g/kg, and exogenous FSH, 150–300 IU, during the late follicular phase of spontaneous cycles. They then received 10,000 IU of human chorionic gonadotropin (hCG) to time accurately follicle aspiration in unstimulated IVF cycles.Results Two women underwent three cycles with Nal-Glu alone on the day of hCG administration. One pregnancy resulted. Five women underwent five cycles with 3 to 6 days of daily Nal-Glu and FSH. Four of these cycles resulted in aspiration after the FSH dose was increased to 300 IU. Nal-Glu and FSH allowed continued development of the dominant follicle without the occurrence of luteinizing hormone (LH) surge.Conclusions (1) Nal-Glu alone given 18 hr prior to hCG did not interfere with continued follicle viability or with the attainment of pregnancy. (2) Simultaneous Nal-Glu and FSH allowed for continued growth and development of the dominant follicle without the occurrence of an LH surge. (3) This preliminary experience confirms the feasibility of this novel approach, which may ultimately enhance the efficacy of unstimulated IVF cycles by eliminating premature ovulation and maximizing control of gonadotropin delivery to the developing follicle.Presented at the 39th Meeting of The Society for Gynecologic Investigation, San Antonio, Texas, March 18–21, 1992.     

Evaluation of delta-aminolaevulinic acid excretion in random urine samples of children

Urinary delta-aminolaevulinic acid (-ALA) excretion was evaluated in random urine samples of 191 healthy children, aged 2–14 years, with blood lead levels <0.8 mol/l (mean ± SD: 0.34±0.13), erythrocyte zinc-protoporphyrin <70 mol/mol haem (mean ± SD: 50.4±8.0) and blood haemoglobin >6.8 mmol/l (mean ± SD: 8.2±0.5). It was found that uncorrected -ALA concentration and -ALA/creatinine ratio are age-dependent, whereas the ratio of -ALA/logarithm of creatinine concentration (mean ± SD: 55.3±13.5 mol/log mmol) is independent of age and sex. The authors recommend the use of this parameter for the assessment of -ALA excretion in random urine samples in children     

某金矿凿岩工症状自评量表调查分析

探讨局部振动对工人心理,行为功能的影响。方法 应用ＳＣＬ－９０量表及一般症状查体资料,对４０名金矿井正业凿岩机工人及其对照组２０名工人进行了调查分析。结果 与对照组比较,凿岩组工人在耳鸣,听力下降,高血压等方面有显著性意义;症状量表听各项指标均与对照组有显著差异,且在工作后１０年内易发生。结论局部振动可造成工人心理,行为功能的改变及一些症状的出现,二者又可相互作用,进一步加重对工人身心健康的危害。     

乙肝血清标记物阳性孕妇的胎盘组织和PBMC的HBVDNA检测及意义

为探讨乙型肝炎病毒（HBV）宫内感染的机理,本文采用原位分子杂交技术,测定了20份外周血HBsAg/HBeAg双阳孕妇胎盘组织和24份HBsAg阳性孕妇外周血单核细胞（PBMC）的HBV DNA,结果发现,胎盘组织HBV DNA均阳性;HBV DNA主要分布于胎盘蜕膜,而绒毛滋养层细胞未见阳性,提示HBV已侵袭胎盘蜕膜,且可能在蜕膜细胞中有复制,但未累及绒毛,PBM HBV DNA测定结果表明,HBV DNA阳性率为58．3％（14／24）,阳性的孕妇中,有2例其婴儿发生了宫内感染。     

糖尿病中医证型的分布及动态资料对比分析

目的:掌握糖尿病住院患者中医证型的分布及动态发展资料。方法:运用统计学方法,对本院1996-1998年所有糖尿病患者的中医病证进行编码、分类、统计。结果:1996年糖尿病患者中医证候分布主要顺位为:肺胃燥热证(29.8%)、气阴两虚证(25.7%)、肾阴亏虚证(22.2%)、阴阳两虚证类(11.1%)。1997年中医证候谱发生变化,顺位为气阴两虚证(41.4%)、肺胃燥热证(24.5%)、阴阳两虚证(20.7%)、肾阴亏虚证(13.8%)。1998年为肺胃燥热证(33.2%)、气阴两虚证(30.5%)、阴阳两虚证(21.3%)、肾阴亏虚证(14.9%)。结论:危害糖尿病患者较重的阴阳两虚证所占病例逐年增多,要引起高度警惕,如不及时治疗,消渴病证候将向严重方向转移,威胁患者生命     

Public health services in Bangladesh with special reference to systems and trends of vital statistics

Health is one of the basic requirements for improvement in the quality of life. Since Bangladesh became independent, a policy for providing essential minimum health care to all has been actively pursued. An overview of Public Health Services in Bangladesh is presented in terms of: (1) a profile of the country, (2) an overview of public health, (3) medical care, and (4) environmental health. Under each of these headings observations are included on recent trends based upon relevant data and information. Finally the authors describe the importance of (1) promotion of health care and planning at the national, divisional, local, and community levels, (2) promotion of medical services at all levels, and (3) effective decentralization of health services to enhance the services of health facilities.     

Health status of male preparatory school students lodging at a dormitory in Japan

An investigation on the health status of 79 male preparatory school students lodging at a dormitory in Japan was carried out by questionnaire on lifestyles, subjective symptoms and mental status, as compared with two control groups: 73 medical students and 36 new employees. About 83 % of them slept less than 6 hours and 70 % of them did not exercise. Many students are troubled with back pain or lumbago(47%), sensation of incomplete bladder emptying(l6%), loss of visual acuity(55%) and eye fatigue(65%). Self-rating depression scale score of preparatory school students was not significantly higher than those of the control groups. The lifestyles of preparatory school students found to be very restricted and strained. However, no significant differences on mental adverse health effects was found among three groups.     

新型导弹驱逐舰舱室大气质量卫生学分析与评价

目的 :舰船作战性及居住性的要求及“全封闭”的环境特点 ,使舱室大气质量的卫生学分析与评价迫在眉睫。方法 :在随舰测定基础上 ,以水面舰艇舱室空气组份容许浓度标准为依据 ;应用人 -机 -环境系统工程理论 ,采用对比方法。结果 :分析归纳了舱室大气污染的主要途径及浓度变化规律 ;提出了舱室大气质量控制建议。结论 :该舰舱室大气质量符合标准。     

黑河上蔡段河水及饮用水的致突变性

目的：探讨黑河上蔡段癌症高发区河水及饮用水的致突变性。方法：采集严重污染的黑河河水及沿岸浅井水分别进行以下试验。①用ＸＡＤⅡ树脂提取各水样中的有机提取物作为待测样品,以呋喃基康酰胺和叠氮钠作阳性对照,以自发回变率为阴性对照,用鼠伤寒沙门氏菌属ＴＡ９８ 、ＴＡ１００ 菌株进行Ａｍｅｓ 试验。以突变比ＭＲ 值评价试验结果。②松滋青皮蚕豆温浸芽约２ ｃｍ ,分别取３ ～４ 粒放入不同水样中处理,同时以蒸馏水、郑州市自来水作阴性对照,环磷酰胺（１ ｍｇ／Ｌ） 作阳性对照进行微核试验。显微镜下观察根尖细胞微核数,统计微核千分率（ＭＣＮ‰） 。结果：①河水有机提取物对ＴＡ９８、ＴＡ１００ 菌株均可诱发阳性回变;②沿岸浅井水有机提取物能诱发ＴＡ９８菌株的阳性回变;③河水、井水均可致蚕豆根尖细胞微核率（ＭＣＮ‰） 明显增高。④浅井水和河水的致突变性及毒性（ 抑菌圈直径大小） 基本相同。结论：①由于浅井水和河水的致突变性及毒性基本相同,故浅井水中的致突变物质可能来源于河水的水平渗透;②沿岸居民癌症高发与河水污染的潜在致癌性有密切关系,应予以高度重视     

正丁基葡萄糖苷合成的反应机理与动力学

在最佳反应条件下,采用直接法由葡萄糖与正丁醇反应合成正丁基葡萄糖苷,研究了该反应的反应机理,提出了直接法合成正丁基葡萄糖苷的宏观动力学模型,该过程为表观假一级可逆反应。