中药干预心室重构的一氧化氮途径研究进展

一氧化氯(nitric oxide,NO)作为一种生物信使,对正常的生理、细胞和组织损伤过程具有调节作用。NO在机体内的生物利用度及合成的改变与多种疾病的病理生理过程密切相关,尤其是作为心血管系统的信号分子,对心血管系统病理生理的调控作用尤为突出。     

中药有效成分胃肠转运的药动学研究进展

中药复方制剂成分复杂,理化性质各不相同,受胃肠道环境的影响和成分之间相互作用的影响,因而其有效成分在胃肠道内的溶出、代谢和吸收情况不同.由于中药复方制剂在胃肠道内的动态变化是机体对药物的最初始作用,并影响到以后的全过程,因此,研究复方制剂在胃肠道内的动态变化,具有极其重要的意义.本文综述了近年来中药胃肠转运药动学的研究进展.     

Is it possible to rapidly and noninvasively identify different plants from Asteraceae using electronic nose with multiple mathematical algorithms?

Many plants originating from the Asteraceae family are applied as herbal medicines and also beverage ingredients in Asian areas, particularly in China. However, they may be confused due to their similar odor, especially when ground into powder, losing their typical macroscopic characteristics. In this paper, 11 different multiple mathematical algorithms, which are commonly used in data processing, were utilized and compared to analyze the electronic nose (E-nose) response signals of different plants from Asteraceae family. Results demonstrate that three-dimensional plot scatter figure of principal component analysis with less extracted components could offer the identification results more visually; simultaneously, all nine kinds of artificial neural network could give classification accuracies at 100%. This paper presents a rapid, accurate, and effective method to distinguish Asteraceae plants based on their response signals in E-nose. It also gives insights to further studies, such as to find unique sensors that are more sensitive and exclusive to volatile components in Chinese herbal medicines and to improve the identification ability of E-nose. Screening sensors made by other novel materials would be also an interesting way to improve identification capability of E-nose.     

中药灌肠治疗胃肠术后腹胀疗效观察

目的观察中药灌肠治疗胃肠术后腹胀的临床疗效。方法 90例胃肠术后腹胀患者随机两组。治疗组采用中药灌肠治疗,对照组口服西沙比利,连续治疗5d后评定疗效。结果治疗组总有效率明显优于对照组(P0.01)。结论中药灌肠治疗胃肠术后腹胀疗效可靠。     

A systematic review and meta‐analysis of randomized controlled trials: Skin‐patch of Chinese herbal medicine for patients with acute gouty arthritis

Aims

To evaluate the evidence of the effectiveness and safety of Chinese herbal medicine skin‐patches for patients with acute gouty arthritis.

Background

Acute gouty arthritis is a problem that can limit the level of activity and impair the quality of life. In China, many clinical studies have demonstrated that skin‐patches of Chinese herbal medicines benefit patients with acute gouty arthritis. However, the reported clinical effects vary.

Design

A systematic review and meta‐analysis of randomized controlled trials.

Data sources

Three English databases including CENTRAL (1993 to February 2017), PubMed (1966 to February 2017) and EMBASE (1974 to February 2017) and four Chinese databases including Chinese National Knowledge Infrastructure, Chinese VIP Information, SinoMed and Wanfang (all, 1949 ‐ February 2017) were searched. Randomized controlled trials that compared skin‐patches of Chinese herbal medicine with or without conventional treatments to conventional treatments, no treatment or a placebo treatment for patients with acute gouty arthritis were included.

Review methods

We conducted a systematic review and meta‐analysis following the Cochrane process. Two authors selected the studies, extracted the data and evaluated the risk of bias of the included trials.

Results

Nineteen studies met our inclusion criteria. After synthesizing the data, the results showed that skin‐patches of CHM combined with Western medicine seemed to be more effective than Western medicine alone for pain relief in patients with acute gouty arthritis and had fewer adverse events.

Conclusion

Due to the quality of the data, larger and more rigorously designed clinical trials with proper outcome measures are necessary.     

中草药与药物性肝损伤

随着中医药和中西医结合研究的发展,中药制剂在我国的临床应用越来越广泛.与其同时,有关中草药及其制剂引起不良反应的报道也有增多之势,最近新发现了一些既往文献无相关毒性记载的案例和毒性物质.因此,重视部分中草药的肝脏毒性,合理用药并加强深入研究,具有重要意义.