《伤寒论》水气证治论析

就《伤寒论》水气的涵义、致病特点、形成与发病、证治等方面进行了分析和探讨。认为：水气是一个病理概念,具有病理产物和致病因素的双重性,其本质是体内停蓄之水,其致病过程具有动而不居的特点;痰饮、水肿、湿痹皆是水气为患。水气的形成机制是阳虚,阳不制阴。治疗以“温药和之”为常法,振奋阳气以祛除水气;非尽以温药和之为变法,攻逐、清热、滋阴皆在其中。     

右室舒张功能的衰老演变规律脉冲多普勒超声心动图研究

目的　检测右室舒张功能的随龄演变规律。方法　用脉冲多普勒超声心动图记录320例健康知识分子的三尖瓣血流频谱,年龄范围26～90岁。结果　右室舒张功能指标Er、EMVr、EDVr、Eir、13FFr、NPFRr、ErAr、随年龄增加分别降低,而EDTcr、Ar、Air、AFFr、随年龄增加而增加。EATcr、EAVr、在各年龄组中无变化。结论　右室的舒张功能年龄增长而减低     

低剂量丙酸倍氯松吸入对轻度哮喘儿童气道高反应性的影响

为探讨低剂量丙酸倍氯松吸入对轻度哮喘儿童肺功能及气道高反应性的影响,将 ３０例轻度哮喘患儿（年龄 ５～ １４岁,男２１例,女 ９例）随机分为 ３组（每组 １０例）,分别吸入安慰剂,ＢＤＰ２００或４００μｇ／日,结果：患儿吸入２００或４００μｇ／日的ＢＤＰ后,哮喘症状明显改善, ＦＥＶＩ及 ＰＥＦ明显升高。且Ｌｏｇ［ＰＤ２０ＦＥＶ１（μｇ）］显著增加即 ＢＨＲ显著下降。其下降程度随吸药时间的延长而增加,而对照组的各项指标均无明显变化。２００μｇ组及４００μｇ组间有关临床症状改善,各项肺功能指标及 ＢＨＲ的变化,不存在显著差异（Ｐ均＜０．０５）。结论：吸入２００μｇ／日的ＢＤＰ即能有效地控制轻度儿童哮喘患者的临床症状,改善其肺功能并降低ＢＨＲ,将剂量增力。至４００μｇ／日并不能明显增力。疗效。建议临床上使用ＢＤＰ吸入疗法治疗轻度儿童哮喘时,宜采用２００μｇ／日为常规剂量。     

工业区大气污染对儿童肺功能影响研究

本文研究工业区大气污染对儿童肺功能影响,分别对大气污染区与对照区儿童进行肺功能测定、问卷调查及大气中ＳＯ２ＮＯｘ监测。     

天津市某工业区大气污染对儿童健康影响的研究

为探讨天津市区大气污染对儿童健康的影响,于１９９５年１０－１１月对天津市某工业区对对照区进行了充行病学调查。调查对象为７－１２岁儿童,结果表明污泥区大气ＳＯ２、ＮＯｘ,ＴＳＰ、ＣＯ浓度均显著高于对照区;     

大豆皂甙抑瘤效应及对荷瘤鼠免疫功能的影响

为了从兔疫学角度探讨大豆皂甙的抑瘤机理,采用T淋巴细胞功能和淋巴因子测定法及细胞毒技术,研究了大豆皂甙对荷瘤鼠肿瘤生长的抑制作用及对荷瘤鼠免疫功能的影响.结果表明,大豆皂甙明显抑制荷瘤鼠肿瘤细胞的生长,促进荷瘤鼠脾和胸腺细胞的增殖反应及脾T淋巴细胞IL-2的分泌,增强LAK和NK肿瘤杀伤细胞的活性.提示大豆皂甙是一种良好的抑制肿瘤细胞生长的免疫调节剂.     

异体LAK细胞联合IL-2治疗慢性乙型肝炎的近期疗效观察

对７３例慢性乙型肝炎患者随机分为两组,即异体ＬＡＫ细胞联合ＩＬ－２治疗组４８例和一般护肝药物对照组２５例。在治疗前及治疗后一个月检测直炎病毒ＤＮＡ〉两对半血清ＨＢＶ标志物、肝功能等项目。结果显示治疗组ＨＢｅＡｇ为６０．４％,ＨＢｃＡｇ、抗ＨＢｃＩｇＭ及ＨＢＶＤＮＡ的阴转率分别为３７．５％、２９．２％和４１．７％。ＨＢｓＡｇ阴转率为６．３％与对照组无显著性差异。治疗组肝功能恢复较对照组佳 。     

视觉电生理联合应用对眼外伤视觉功能的评价

联合使用视觉电生理检查法评估外伤眼的视功能。方法单纯眼外伤３０例按受伤程度分３组,健康对侧眼为对照组,比较各组ＶＥＰＰ１００波潜伏值,３０Ｈｚ红闪炮光ＥＲＧ的振幅和暗适应ＥＲＧａ、ｂ波振幅的平均值。结论联合应用视觉电生理检测法是评价眼外伤视功能的可靠依据。     

Left ventricular hypertrophy and geometry in a population sample of elderly males

BACKGROUND: Recent studies have shown that left ventricular geometric adaptationto hypertension is complex. The spectrum of geometric adaptationsin a general population and its relationship to systolic anddiastolic function has, however, not been investigated. OBJECTIVES AND METHODS: This echocardiographic and Doppler study investigated the relationshipsbetween left ventricular geometric shape (normal, concentricremodelling, concentric hypertrophy and eccentric hypertrophy)and left ventricular systolic and diastolic function in a populationsample of 584 males aged 70 in Uppsala, Sweden. The influencesof hypertension, coronary heart disease and diabetes mellituswere also evaluated. RESULTS: Sixteen percent of the healthy population (n=167) demonstratedthe presence of left ventricular hypertrophy (mainly eccentric).Subjects with hypertension (n=115) showed an increased leftventricular mass (eccentric left ventricular hypertrophy 31%,concentric left ventricular hypertrophy 15%), when comparedwith healthy subjects (P<0.001). Subjects with coronary heartdisease (n=32) without hypertension also showed an increasedleft ventricular mass (most often eccentric) (P<0.05). UsingDoppler determinations of cardiac index, no differences werefound in cardiac index between the geometric groups. Raisedtotal peripheral resistance, increased blood pressure and enlargedleft atrium were found in both concentric and eccentric leftventricular hypertrophy (P<0.01–0.05). Disturbed diastolicfunction was seen with a prolongation of the isovolumic relaxationtime in eccentric (P<0.01) and increased atrial-dependentleft ventricular filling in concentric left ventricular hypertrophy(P<0.05). CONCLUSIONS: Alterations in left ventricular geometry were common in thispopulation-based study of elderly males, both in healthy subjectsand in subjects with hypertension or coronary heart disease.Raised total peripheral resistance and left ventricular diastolicdysfunction were common findings in both concentric and eccentricleft ventricular hypertrophy.     

Regional myocardial motion and thickening assessed at rest by ECG-gated99mTc-MIBI emission tomography and by magnetic resonance imaging

We have validated ECG-gated emission tomography using technetium-99m methoxyisobutylisonitrile for the assessment of regional ventricular function by comparing it with cine magnetic resonance imaging (MRI). Gated tomography was performed at rest in 24 patients referred for myocardial perfusion imaging [17 males and seven females with a mean age of 58 years, nine of whom had had a previous myocardial infarction (MI)]. Scores were assigned to each of nine myocardial segments for wall motion and for thickening. Cine MRI was analysed in an identical fashion. Four out of 216 (2%) segments were uninterpretable by gated tomography because of inadequate tracer uptake. In eight patients without coronary artery disease (CAD), wall motion and thickening were normal by both methods. Gated tomography showed abnormal wall motion or thickening in all patients with previous MI and in five of seven patients with CAD but no prior MI. Association between wall motion and thickening was good (r _s=0.86). Overall, there was good agreement between gated tomography and MRI for both wall motion (178/212 segments, =0.66) and wall thickening (184/212 segments, =0.69). In segments with severely reduced perfusion, however, there was poorer agreement (=0.31). Interobserver and intraobserver agreement was high ( from 0.61 to 0.78). Thus, in patients investigated for CAD, there is good overall agreement between gated tomography and MRI but the agreement is lower in segments with severe perfusion defects.