Herb remedies during pregnancy: a systematic review of controlled clinical trials

Objective: The use of herbal remedies has been documented both among various patient groups and in the general population to promote health. The aim of this systematic review is to analyze the benefits of herb use during pregnancy. Methods: A systematic literature search covering the period from January 1990 to September 2010 was performed using various electronic databases. Randomized controlled clinical trials (RCTs) were included. Paper quality was evaluated using the Jadad scale. Results: Of the 511 articles identified, 14 RCTs were eligible. Ginger was the most investigated remedy and was consistently reported to ameliorate nausea and vomiting during pregnancy better than placebo; its efficacy in doing so was noted to be equal to that of vitamin B6 and dimenhydrinate. A single trial also supported the use of Hypericum perforatum for wound healing. Cranberry, however, was not efficacious in the treatment of urinary tract infections; finally, raspberry leaf did not shorten the first stage of labor, and garlic did not prevent pre-eclampsia. Conclusions: Despite the widespread, popular use of herbal remedies during pregnancy, too few studies have been devoted to specific clinical investigations. With the exception of ginger, there is no data to support the use of any other herbal supplement during pregnancy.     

基于代谢组学研究姜制对黄连药性的影响

目的 探讨黄连姜制前后寒热药性的差异。方法 分别制备生黄连、姜黄连水煎液,每天ig给予大鼠1次,连续给药29 d,于给药后不同时间点采集血样,进行HPLC-MS/MS分析,主成分分析（PCA）法处理实验数据,分析生黄连和姜制黄连在血浆中的代谢物的差异。结果 给药第29天生黄连组和姜黄连组大鼠血样中内源性物质的代谢状态差异最大。通过查找内源性生物标记物发现,与生黄连组相比,姜黄连组大鼠血样中代谢物中涉及到氨基酸能量代谢的标记物的量增加,提示姜制黄连组氨基酸能量代谢强于生黄连,二者寒热药性存在差异。结论 通过大鼠代谢物生物效应可以考察生黄连与姜黄连药性的差异,且结果与传统的“姜制黄连以热制寒,缓和黄连苦寒之性”的炮制理论相一致。代谢物组学可用于探讨炮制对药物药性影响的研究。     

Occupational allergic contact dermatitis from spices

About 1000 patients were investigated at our clinic during 1991 for occupational skin disease. and 5 had occupational allergic contact dermatitis from spices. The patients were chefs, or kitchen, coffee room, and restaurant workers. All patients had hand (or finger) dermatitis. The causative spices were: garlic, cinnamon, ginger, allspice and clove, The same patients also had allergic patch test reactions to foods: tomato, lettuce and carrot. Paprika elicited a weak allergic patch test reaction in 2 patients. Occupational allergic contact dermatitis from spices is relatively rare, but needs to be taken into consideration in patients who have hand dermatitis, and work with spices and foods, Patch testing with spices as is useful, but testing with dilutions in pet, may be needed to confirm that the patch test reactions are allergic. Patients also need to be prick tested with spices and foods.     

海白延遂膏穴位贴敷配合隔姜灸治疗慢性支气管炎100例

目的:观察海白延遂膏穴位贴敷配合隔姜灸治疗慢性支气管炎的临床疗效.方法:将200例符合诊断标准的慢性支气管炎患者随机分为治疗组、对照组各100例.治疗组于每伏第2天给予海白延遂膏穴位贴敷配合隔姜灸治疗;对照组于每伏第2天行针灸治疗.2组均每伏治疗1次,治疗3次为1个疗程,治疗1个疗程后观察疗效.结果:治疗组总有效率92...     

干姜醇提取物对肠道平滑肌运动的影响

目的 研究干姜醇提取物(EDGE)对肠道平滑肌运动的影响及其作用机制. 方法 通过小鼠小肠墨汁推进实验观察EDGE对正常、亢进及抑制状态下肠道运动的影响, 并采用兔体外肠管实验从胆碱能通路初步探讨其作用机制. 结果EDGE能显著促进正常和抑制状态的小鼠小肠运动,对亢进状态的小鼠小肠运动却有明显抑制作用. EDGE能显著促进正常体外肠管收缩,对阿托品预孵育的体外肠管也有明显促进收缩作用,对乙酰胆碱(Ach)引起的肠管收缩反应却有拮抗作用,并存在量效关系. EDGE(1 mg•mL^-1)使无钙离子蒂罗德液中Ach收缩肠管作用明显减弱,但不影响氯化钙引起的肠管收缩. 结论 EDGE对肠道平滑肌运动有双向调节作用,这种作用与胆碱能受体有关.     

抗皮肤癣菌用姜油树脂凝胶的质量控制

[目的]建立抗真菌用姜油树脂凝胶制剂的质量控制标准。[方法]以6-姜酚为对照品,采用高效液相色谱法,色谱柱为HYPERSIL BDS C18(5μm,4.6 mm×250 mm)加预柱,流动相为甲醇∶水=65∶35,检测波长280 nm,测定姜油树脂凝胶中6-姜酚的含量。[结果]6-姜酚的线性范围是0.06~1.2 mg/mL,r=0.9999;精密度、重复性、稳定性的RSD值均<2%,平均回收率为98.30%,RSD=0.95%。[结论]本实验建立的测定姜油树脂凝胶中6-姜酚含量的高效液相色谱法,结果可靠,操作简便,可以作为姜油树脂凝胶的质量控制标准。     

生姜陈皮汤对顺铂所致水貂呕吐模型的治疗作用

目的 研究生姜陈皮汤对顺铂所致水貂呕吐模型的治疗作用.方法 雄性水貂随机分为5组:正常对照组、模型对照组、昂丹司琼组、生姜陈皮汤低剂量组和高剂量组,各组分别给予生理盐水、生理盐水、昂丹司琼、生姜陈皮汤低剂量和高剂量处理两天,第2天处理后30 min除正常对照组外各组水貂给予腹腔注射顺铂,观察注射顺铂后6 h内水貂呕吐潜伏期,干呕及呕吐次数.结果 与模型组比较,生姜陈皮汤高、低剂量组和昂丹司琼组均能显著延长呕吐潜伏期(P<0.05,P<0.01),并明显减少干呕及呕吐次数(P<0.01).结论 生姜陈皮汤对顺铂所致的水貂呕吐具有治疗作用.     

壮医鲜姜汁敷背治疗风寒型感冒疗效观察

目的：观察壮医鲜姜汁敷背对风寒型感冒的临床疗效。方法：将110例风寒型感冒患者分为治疗组（壮医姜疗组）60例,对照组（常规中药治疗组）50例,比较两组治疗后的临床疗效。结果：两组治疗后,壮医姜疗组在体温下降、症状减轻或消除、血象改善等方面有显著效果（P〈0．05）,统计学差异显著。结论：壮医鲜姜汁敷背疗法对风寒型感冒有显著疗效。