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排序方式: 共有403条查询结果,搜索用时 349 毫秒
31.
Mano Y Aishima S Fujita N Taketomi A Shirabe K Maehara Y Oda Y 《Pathology, research and practice》2011,207(10):659-663
We report on three cases of cystic neoplasms of the liver with mucinous epithelium. Case 1 showed a low-grade cystic neoplasm with ovarian-like stroma (OS). Case 2 showed a low-grade cystic neoplasm without OS, and case 3 showed a high-grade cystic neoplasm without OS. In all three cases, bile duct communication (BDC) was absent. Currently, pancreatic mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm of the pancreas (IPMN) are clearly distinguishable. However, MCN of the liver and intraductal papillary neoplasm of the bile duct (IPN-B) are not as easily distinguished. According to the latest WHO classification (2010), these conditions are classed as typical MCN of the liver, MCNs of the liver without OS, or IPN-Bs without BDC. The clinicopathological differences between MCN without OS and IPN-B without BDC are controversial. We present three cases describing these presentations and discuss the difficulties related to the diagnostic criteria used to distinguish between MCN of the liver and IPN-B. 相似文献
32.
The aim of the present study was to examine the influence of urinary flow rate on markers of renal function in children. A
sub-study of the New England Children’s Amalgam Trial collected 82 pairs of urine samples from children aged 10–16 years:
a timed overnight collection and a spot daytime sample collected the following day. These samples were analyzed for albumin,
γ-glutamyl transpeptidase (γ-GT), N-acetyl-β-D-glucosaminidase (NAG), alpha1-microglobulin (A1M), and creatinine concentration. Regression analysis was used to model the
effect of urinary flow rate in the timed overnight samples. A paired t-test compared concentrations and creatinine-corrected renal markers between overnight and daytime samples. Albumin, γ-GT,
NAG, and A1M excretion rates increased significantly with urinary flow rate. Their corresponding creatinine-corrected markers
did not vary significantly with urinary flow rate, but the creatinine-corrected excretions of albumin, γ-GT, and NAG were
significantly higher in daytime samples than in overnight samples, with the same (non-significant) trend for A1M. The influence
of urinary flow rate on creatinine-corrected markers of renal function was markedly less than its influence on excretion rates.
Therefore, the use of creatinine-corrected markers seems to be a good choice in practice, with the caveat that daytime and
overnight samples are not comparable.
This study was supported by a cooperative agreement (U01 DE11886) between the New England Research Institutes and the National
Institute of Dental and Craniofacial Research, National Institutes of Health. 相似文献
33.
34.
B. Jankskov V. Lisý F. astný 《International journal of developmental neuroscience》1992,10(3):225-230
Inhibitors of gamma-glutamyl transpeptidase (mixture of serine and borate--13 mM, kainic acid--5 mM and 6-diazo-5-oxo-L-norleucine--2 mM) significantly suppressed glutamate uptake into cultured neurones and glial cells. The simultaneous application of any of these inhibitors with ouabain resulted in a further decline in glutamate uptake. It can be speculated that gamma-glutamyl transpeptidase significantly contributes to glutamate transport into nerve cells in the early period of brain development until the Na(+)-K(+)-gradient is fully constituted. 相似文献
35.
《Nutrition, metabolism, and cardiovascular diseases : NMCD》2022,32(5):1292-1300
Background and aimsElevated circulating levels of CathepsinD (CatD) have been linked to metabolic deviations including liver inflammation. We investigated 1) whether supplementation with probiotics and/or fish oil affects CatD and 2) whether the CatD concentration would associate with gestational diabetes (GDM), low-grade inflammation, lipid metabolism, body fat % and dietary composition.Methods and resultsOverweight/obese pregnant women (n = 438) were randomized into fish oil + placebo, probiotics + placebo, fish oil + probiotics or placebo + placebo groups. Fish oil contained 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid and probiotics were Lacticaseibacillus rhamnosus HN001 (formerly Lactobacillus rhamnosus HN001) and Bifidobacterium animalis ssp. lactis 420, 1010 colony-forming units each). Serum CatD levels were analysed by ELISA, GlycA and lipid metabolites by NMR, high sensitive C-reactive protein (hsCRP) by immunoassay, and intakes of energy yielding nutrients and n-3 and n-6 fatty acids from food diaries at both early and late pregnancy. GDM was diagnosed by OGTT. CatD concentrations did not differ between the intervention groups or by GDM status. Multivariable linear models revealed that body fat % and GlycA affected CatD differently in healthy women and those with GDM.ConclusionThe serum CatD concentration of pregnant women was not modified by this dietary intervention. Serum CatD was influenced by two parameters, body fat and low grade inflammation, which were dependent on the woman's GDM status.Clinical trial reg. noNCT01922791, clinicaltrials.gov (secondary analysis). 相似文献
36.
《Allergology international》2020,69(1):28-34
Eosinophils are multifaceted immune cells with diverse functions that enhance allergic inflammation. Cysteinyl leukotrienes (cys-LTs), mainly synthesized in eosinophils, are a class of inflammatory lipid mediators produced via multiple enzymatic reactions from arachidonic acid. Multiple clinical studies have reported dysregulated fatty acid metabolism in severe asthma and aspirin-exacerbated respiratory diseases. Therefore, understanding the mechanism responsible for this metabolic abnormality has attracted a lot of attention. In eosinophils, various stimuli (including cytokines, chemokines, and pathogen-derived factors) prime and/or induce leukotriene generation and secretion. Cell–cell interactions with component cells (endothelial cells, epithelial cells, fibroblasts) also enhance this machinery to augment allergic responses. Nasal polyp-derived eosinophils from patients with eosinophilic rhinosinusitis present a characteristic fatty acid metabolism with selectively higher production of leukotriene D4. Interestingly, type 2 cytokines and microbiome components might be responsible for this metabolic change with altered enzyme expression. Here, we review the regulation of fatty acid metabolism, especially cys-LT metabolism, in human eosinophils toward allergic inflammatory status. 相似文献
37.
《Clinics and research in hepatology and gastroenterology》2022,46(8):101968
ObjectivesThe accuracy of non-invasive liver fibrosis diagnosis based on the apparent diffusion coefficient (ADC) value combined with the γ-glutamyl transpeptidase-to-platelet ratio (GPR) model to predict the stage of hepatitis B-related fibrosis has not been reported. This study aimed to evaluate the diagnostic efficacy of ADC value combined with GPR for liver fibrosis grading.MethodsThe data of 180 patients with chronic hepatitis B (CHB) diagnosed by liver biopsy were analyzed. The ADC value, GPR, and their combination were assessed in different cirrhosis stages using receiver operating characteristic curve analysis to evaluate their value in diagnosing liver fibrosis.ResultsWe observed that liver fibrosis stages were inversely associated with ADC values (r=?0.691, P<0.001), and positively associated with GPR (r=0.502, P<0.001). The area under the curve for diagnostic efficacy of ADC values, GPR, and their combination for F≥2 liver fibrosis was 0.831, 0.749, and 0.858, respectively, and for F≥3 was 0.872, 0.771, and 0.903, respectively. The diagnostic cutoffs of the combination for each stage were -7.07, -12.21 and -37.75, respectively.ConclusionsThe combined diagnostic tool of ADC and GPR may improve the accuracy of hepatitis B-related liver fibrosis diagnosis, especially for F≥3. 相似文献
38.
39.
Anthony P. Polednak 《The American journal of drug and alcohol abuse》2013,39(3):403-409
Alcohol use has been associated with increased risk and poorer prognosis of various types of cancer, but the extent of actual screening for alcohol use in hospitalized cancer patients has received limited attention. In a random sample of 618 Connecticut patients diagnosed in 2002 with invasive cancer at age 20 + years, ascertained from a population-based registry, some information on usual frequency of drinking was found in hospital records for 478 (77.3%), but 143 (57.2%) of the 250 current drinkers were poorly described (e.g., “social,” “occasional”). Alcohol use disorders were rarely mentioned. Gamma glutamyl transpeptidase was found for only 21 (3.4%). Mean corpuscular volume (MCV) was found for 434 (70.2%) and was associated with heavier drinking, independent of other predictors of MCV. Better screening is needed for all hospitalized cancer patients, to plan for interventions and conduct follow-up studies of prognosis. 相似文献
40.
调查58名镉(Cd)作业工人尿中γ-GT同功酶的变化。结果发现,所有Cd作业工人尿中γ-GT,γ-GTⅠ,γ-GTⅡ均超出正常值上限。无肾损伤组的工人尿γ-GT,7·GTⅠ,γ-GTⅡ明显地高于对照组,而γ-GTⅠ/γ-GTⅡ值无明显变化;重度肾损伤组,尿γ-GT,γ-GTⅠ水平高于无肾损伤和进度肾损伤组,而尿γ-GTⅠ/γ-GTⅡ则呈下降趋势。结果提示,尿γ-GT可能作为Cd接触者健康监测的一个敏感指标;尿γ-GTⅠ/γ-GTⅡ值的变化似与Cd作业工人肾损伤程度有关。 相似文献