Semiparametric estimation of single‐index hazard functions without proportional hazards

Summary This research develops a semiparametric kernel‐based estimator of hazard functions which does not assume proportional hazards. The maintained assumption is that the hazard functions depend on regressors only through a linear index. The estimator permits both discrete and continuous regressors, both discrete and continuous failure times, and can be applied to right‐censored data and to multiple‐risks data, in which case the hazard functions are risk‐specific. The estimator is root‐n consistent and asymptotically normally distributed. The estimator performs well in Monte Carlo experiments.     

Prediction of muscle stretch receptor behavior using Wiener kernels

The input-output characteristics of muscle stretch receptors can be represented by a set of Wiener kernels estimated from responses to random length stimuli. We use these kernels to predict the responses of the receptor to deterministic length changes and show that significant non-linearities are present in receptor responses to length stimuli of only a fraction of a millimeter.     

Exact orthogonal kernel estimation from finite data records: Extending Weiner's identification of nonlinear systems

A technique is described for exact estimation of kernels in functional expansions for nonlinear systems. The technique operates by orthogonalizing over the data record and in so doing permits a wide variety of input excitation. In particular, the excitation is not limited to inputs that are white, Gaussian, or lengthy. Diagonal kernel values can be estimated, without modification, as accurately as off-diagonal values. Simulations are provided to demonstrate that the technique is more accurate than the Lee-Schetzen method with a white Gaussian input of limited duration, retaining its superiority when the system output is corrupted by noise.     

桃花的药用价值研究

目的:探讨中药桃花的功效及应用现状.方法:通过查阅古籍及近年的相关文献,将桃花的功效及应用现状进行概括总结.结果:桃花系蔷薇科李属落叶乔木桃树的花瓣,它既是良药,又是天然美容品,还可烹调,用途极其广泛.目前其应用仅限于中医经典方剂,其功能的拓展开发十分有限.结论:探索桃花的化学成分及作用机理十分必要,有助于挖掘其药用潜力,拓展临床应用.     

Volumetric magnetic resonance imaging classification for Alzheimer’s disease based on kernel density estimation of local features

Background The classification of Alzheimer's disease (AD) from magnetic resonance imaging (MRI) has been challenged by lack of effective and reliable biomarkers due to inter-subject variability.This ar...     

对藏药甘青青兰4种提取物抑菌作用的研究

目的：研究藏药甘青青兰4种不同提取物对4种临床常见标准菌株的抑菌活性。方法：通过体外抑菌实验,用琼脂扩散法测定甘青青兰4种提取物有无抑菌活性。结果：甘青青兰（炒制）水提取物、生药材水提取物、生药材乙醇提取物在一定浓度（0.15 g/mL,0.2 g/mL）对金黄色葡萄球菌有抑菌或杀菌作用,甘青青兰（炒制）的乙醇提取物对金黄色葡萄球菌无抑菌作用。高浓度甘青青兰（炒制）的水提取物和乙醇提取物对铜绿假单胞菌有抑菌作用,且乙醇提取物的抑菌效果更好。结论：甘青青兰提取物对金黄色葡萄球菌和铜绿假单胞菌有确切的抑菌作用,对大肠杆菌和粪肠杆菌无抑菌作用。     

炒粳米粉预防能全力引起的脑卒中患者腹泻108例临床观察

目的 观察炒粳米粉对减少脑卒中患者由肠内营养制剂能全力引起腹泻并发症的治疗效果。方法 从2009—2011年入住我院神经内科进行肠内营养治疗的脑卒中患者中选取108例符合条件的病人,随机平分为两组,试验组在能全力中加入炒粳米粉,对照组仅仅使用能全力,观察病人服用能全力后腹泻发生情况。结果 试验组腹泻发生率明显低于对照组（P<0.01）。结论 在能全力中添加炒粳米粉可有效减少脑卒中患者由能全力引起的腹泻。     

The Empiric Use of Palm Kernel Oil in Neonatal Skin Care： Justifiable or Not？

Palm kernel oil is a vegetable oil derived from Elaeis guineensis and widely used in neonatal settings for skin care.It is a good emollient with a beneficial effect in moisturizing the skin and preventing transdermal heat and water loss.However,it’s putative roles in the prevention or treatment of fatty acid deficiency is still controversial.So is its function in the improvement of neurological development from its long-chain polyunsaturated fatty acids? We set out in this review to verify whether its empiric use in this context has any scientific justification and is recommendable.Although there is evidence that it has emollient and moisturizing properties necessary for softening the skin and restoring elasticity,controversy subsists on its other nutritional and neurodevelopmental properties.     

针刀松解配合中药内服治疗冻结肩60例临床疗效的分析

目的 观察针刀松解配合中药内服治疗冻结肩的临床疗效,并探讨针刀松解治疗冻结肩理论依据。方法 60例患者行小针刀粘连松解术,术后给予桃红四物汤加减治疗,并指导患者进行主动和被动的功能锻炼。随访6~12个月,平均7.3个月,对治疗前后的肩关节分别以ASES评分、VAS疼痛评分法、Constant肩关节功能及活动度(ROM)评分法进行对比分析。结果 (1)术后3个月,本组患肩活动明显改善,外展(90.66±14.34)°,前屈(124.21±16.44)°,内收(75±12.31)°;(2)术后3个月VAS疼痛评分(1.81±1.02)分较术前(7.86±1.35)分显著降低;(3)术后未出现肩关节不稳症状;(4)术后3个月Constant评分(52.2±13.2)分较术前(22.4±19.4)分明显改善。结论针刀松解配合中药内服治疗冻结肩,可显著改善患者的疼痛与功能障碍程度,创伤小,疗程短,见效快,疗效可靠,且中远期随访显示疗效稳定。