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991.
C. C. Obihara N. Beyers R. P. Gie M. O. Hoekstra J. E. Fincham B. J. Marais C. J. Lombard L. A. Dini J. L. L. Kimpen 《Clinical and experimental allergy》2006,36(5):640-648
BACKGROUND: Epidemiological relation of intestinal helminth infection and atopic disease, both associated with a T-helper (Th) 2 immune response, is controversial, as it has been reported that helminth infection may either suppress or pre-dispose to atopic disease. This relation has not been tested in an area with a high burden of Mycobacterium tuberculosis (MTB) infection, a known Th1-stimulating infection. OBJECTIVE: To study the association of intestinal helminth infection and atopic disease in a community where helminth infection is endemic and MTB infection is high. METHODS: Three-hundred and fifty-nine randomly selected children aged 6-14 years from a poor urban suburb were tested with allergy questionnaire, skin prick test (SPT) to common aeroallergens, Ascaris-specific IgE (Ascaris-sIgE), fecal examination for pathogenic intestinal helminths and tuberculin skin testing (TST). Histamine bronchoprovocation was tested in the group of children aged 10 years and older. RESULTS: were corrected for demographic variables, socioeconomic status, parental allergy, environmental tobacco smoke (ETS) exposure in the household, recent anthelminthic treatment and for clustering in the sampling unit. Results Ascaris-sIgE was elevated in 48% of children, Ascaris eggs were found in 15% and TST was positive in 53%. Children with elevated Ascaris-sIgE had significantly increased risk of positive SPT to aeroallergens, particularly house dust mite, atopic asthma (ever and recent), atopic rhinitis (ever and recent) and increased atopy-related bronchial hyper-responsiveness. In children with negative TST (<10 mm), elevated Ascaris-sIgE was associated with significantly increased risk of atopic symptoms (adjusted odds ratio (OR(adj)) 6.5; 95% confidence interval (CI) 1.9-22.4), whereas in those with positive TST (>/=10 mm) this association disappeared (OR(adj) 0.96; 95% CI 0.4-2.8). CONCLUSIONS: These results suggest that immune response to Ascaris (Ascaris-sIgE) may be a risk factor of atopic disease in populations exposed to mild Ascaris infection and that MTB infection may be protective against this risk, probably by stimulation of anti-inflammatory networks. 相似文献
992.
目的 分析主观症状及实验检查对早期干眼症患者诊断的意义。方法 对55例(109眼)已确诊的早期干眼症患者(无或仅伴有轻微体征)的临床症状及实验检查进行回顾性分析及比较。结果 患者中主观症状所占比率:干涩感94%,视疲劳感82%,异物感74%,明显高于其他症状(P〈0.05)。实验检查的阳性率:基础泪液分泌试验(Schirmer I test,SIt)35%,泪膜破裂时间检查(break-up time,BUT)85%,角结膜荧光素(fluorescent,FL)染色60%,其中BUT阳性率明显高于SIt和FL(P〈0.05)。结论 主观症状及实验检查可为早期干眼症诊断提供有利依据。 相似文献
993.
目的:观察代文胶囊治疗高血压病的临床疗效。方法:60例高血压病患者停用其它降压药1周服用代文胶囊80mg.qd晨服,服药1周后若舒张压仍/〉90mmHg者剂量改为160mg/d,治疗前及治疗后4周分别行动态血压监测,并观察该药的副作用,治疗前后肝肾功能及电解质变化。结果:38例服用80mg/d,22例服用160mg/d,显效33例(55%)有效21例(35%)无效10例(10%),总有效率90%,治疗前后无肝肾功能,血电解质变化。结论:代文胶囊疗效确切,降压作用平稳,能防止晨问血压升高,降低心血管事件发生,值得临床推广应用。 相似文献
994.
F Gerald R Fowkes Lip-Ping Low Sorin Tuta Joseph Kozak 《European heart journal》2006,27(15):1861-1867
AIMS: AGATHA (a Global Atherothrombosis Assessment) was designed to assess the extent of atherothrombosis and the use of the ankle-brachial index (ABI) in vascular patients. The principal hypotheses were that (1) in diseased patients, a low ABI was related to the number and site of vascular beds affected and (2) in at-risk patients without disease, a low ABI was related to the number of risk factors present. METHODS AND RESULTS: Patients were recruited consecutively by 482 clinicians in 24 countries and the ABI measurement was performed at a single visit. Of 8891 patients recruited, 1792 were defined as at risk and 7099 as with disease. Of the with-disease patients, 65.2% had one arterial bed affected, 27.6% two and 7.1% all three. Abnormal ABI (< or =0.9) was present in 30.9% of at-risk and 40.5% of with-disease patients. A lower ABI was weakly associated with an increasing number of risk factors in at-risk patients (r=-0.056, P=0.02) and with the site and number of arterial beds affected in with-disease patients (P<0.001). CONCLUSION: This large international study confirms that atherothrombotic disease often occurs at more than one site. The ABI is related to the risk factor profile and to the site and extent of atherothrombosis. 相似文献
995.
Menno van Gameren Maarten Witsenburg Johanna J M Takkenberg Derize Boshoff Luc Mertens Anton M van Oort Dani?l de Wolf Matthias Freund Narayanswani Sreeram Regina B?kenkamp Melle D Talsma Marc Gewillig 《European heart journal》2006,27(22):2709-2715
AIMS: Stenting has become an established interventional cardiology procedure for congenital heart disease. Although most stent procedures are completed successfully, complications may occur. This multicentre study evaluated early complications after stenting in patients with congenital heart disease, including potential risk factors. METHODS AND RESULTS: In this combined Dutch-Belgian retrospective study, 309 consecutive patients had undergone 366 catheterizations and received 464 stents in 13 different anatomical positions (418 sites). Seventy-two stenting-related complications (19%) occurred, of which 24 (5.7%) were major. Seven procedure-related deaths were documented (2.3%). Stent malpositioning and embolization were most common (7.7%). The use of non-premounted stents tended to be associated with higher complication rates. Centre inexperience with stenting and stenting of native vs. post-surgical stenosis tended to be associated with increased major complication rates. CONCLUSION: After stenting, complications are common for congenital heart disease. The vast diversity of stenotic sites combined with relatively small patient populations makes these procedures sensitive to complications. Combining operator experience may reduce the risks of stenting in congenital heart disease. The availability of premounted stents for greater vessel diameters will likely reduce incidences of stent migration and embolization. 相似文献
996.
用气相色谱法分析了小鼠眼球中脂肪酸的组成及百分含量。分离是在25m×0.25mmPEG-20M熔融石英毛细管柱内进行,眼球中12种主要饱和及不饱和脂肪酸得到了定性和定量。本实验可为有关眼疾病的治疗、预防及生化方面的深入研究提供有意义的信息。 相似文献
997.
Cholesterol reduction and death from noncoronary causes: evidence from randomised controlled trials*
Stephen MacMahonf 《Internal medicine journal》1994,24(1):120-123
An overview of randomised trials of cholesterol reduction (26 trials, 50,000 patients, net cholesterol reduction ?10%) provides clear evidence of a reduction in the incidence of coronary heart disease (CHD) after just a few years of treatment. Overall, the observed reduction in CHD death (9%± 3) was only half as large as the reduction in non-fatal myocardial infarction (19%±4), although both were statistically significant (2p <0.005). In these trials, 60% of all deaths were from CHD, and since treatment reduced these by about 9%, the expected reduction in total deaths was about 5–6%. This expected reduction falls within the 95% confidence interval of the observed effect of cholesterol reduction on total mortality in these trials. There were small excesses of deaths from cancer and deaths from trauma among patients allocated active treatment. However, in no single trial, nor in the trials collectively, were these increases individually statistically significant. Furthermore, the increases did not appear to be specific to any one agent nor were the increases consistent between trials of the same agent. These observations suggest that the small excesses of noncoronary deaths observed in the cholesterol reduction trials may have occurred by chance. Evidence from ongoing longer-term studies of treatments producing larger cholesterol reductions will be useful in further delineating the effects, if any, of such treatments on non-coronary mortality. 相似文献
998.
Yoshio Mitsuyama M.D Hiroyuki Hashiguchi M.D Toshihiko Murayama M.D Masashi Koono M.D Shohei Nishi M.D 《Psychiatry and clinical neurosciences》1992,46(3):741-748
Abstract: A 78-year-old male with renal carcinoma was treated with a high dose infusion of interferon-alpha (IFN-alpha) for eight months. The patient had evidence of organlc brain syndrome such 88 : dysfunction of memory, slowing of behavior, and development of mental confusion that appeared eight months after the treatment. MRI at the time of mental confusion revealed difise white matter lesions. Neuropathologic findings were compatible to Binswanger's disease and Senile Dementia of Alzheimer Type (SDAT), Preexisting neurologic abnormalities including intracerebral arteriosclerosis and cerebral atrophy may increase susceptibility to unacceptably severe IFN neurotoxicity. 相似文献
999.
女性乳头湿疹样癌与乳腺癌浸润乳头之间区别的探讨 总被引:5,自引:0,他引:5
本文对1980~1982年间.天津肿瘤医院收治可手术原发女性乳腺癌715侧重新复习。根据镜下在乳头皮肤见到paget细胞以及癌直接浸润(或累及)乳头,确定乳头湿疹样癌20例,乳腺癌浸润乳头69例。比较两组在临床表现、病理形态和预后的差异。结果发现,乳头湿疹样癌的临床表现以乳头糜烂,结痂为主,而乳腺癌浸润乳头则以乳头凹陷、皮肤粘连、桔皮样变和乳头抬高为主;镜下形态,乳头湿疹样癌主要是在乳头表皮内见到Paget细胞,晚期亦可浸及乳头基质。乳腺癌浸润乳头主要特点是癌细胞浸润乳腺导管,管壁可完整或被浸破,癌亦可直接浸润乳头基质,绝大多数皮肤正常,直接累及皮肤少见,均无Paget细胞。通过本文研究,作者认为乳头湿疹样癌为乳腺癌的独立类型,其在临床表现、病理形态及预后等方面,均与乳腺癌浸润乳头有显著区别。 相似文献
1000.
Hospital discharge data from New Jersey were used to identify cases of asbestosis for the 8 years 1979-1986. Multiple admissions were deleted so that each individual was counted once at the time of his/her first hospitalization with an asbestosis diagnosis. White males had the highest age-adjusted average annual discharge rate of 19.3 cases/100,000 population, followed by black males (12.3 cases/100,000) and white females (1.2 cases/100,000). The discharge rate was positively associated with age in each race/sex category. The relationship between rates for black males and white males depended on age: under 65 years, the rates were almost equal, and at 65 years and older, the white rates were nearly twice the black rates. There were two areas of the state where the rates were highest: the north-central and southwest regions. These two areas represent manufacturing and shipbuilding applications of asbestos, respectively. During the years 1979-1986, the annual percentage increase in asbestosis rates was 20% for white males, 17% for black males, and 8% for white females. Continued surveillance will reveal when the rates for asbestosis stop increasing. 相似文献