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71.
72.
癫痫持续状态及其治疗--附86例报告 总被引:4,自引:0,他引:4
目的:本文报告86例癫痫持续状态,年龄12~80岁,平均(48.63±18.11)岁.男37例,女49例.其中强直-阵挛持续状态60例,阵挛-强直-阵挛持续状态21例,强直持续状态型3例及复杂性部分型癫痫持续状态-精神运动癫痫持续状态2例.方法:本组治疗分为苯巴比妥钠肌注组45例,安定静脉注射组41例.结果:两组在控制癫痫持续状态时为(28.53±10.95)min对(33.85±11.53)rmin,P<0.05.结论:说明苯巴比妥和安定联合用药效果好. 相似文献
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Effects of benzodiazepines on laryngeal reflexes 总被引:2,自引:0,他引:2
Of 20 volunteers, five were given intravenous Diazemuls 15 mg over 15 seconds, and three groups of five were given lormetazepam 2 mg intravenously over 10, 20 and 60 seconds, respectively. Laryngeal reactivity and psychomotor function were tested at intervals from prior to injection until 4 hours after injection. For equivalent degrees of depression of psychomotor function, lormetazepam depressed the laryngeal reflex less than Diazemuls (p = 0.004). Lormetazepam give over 60 seconds depressed the laryngeal reflex more than when given over 10 seconds (p = 0.008) or over 20 seconds (p = 0.048), although a significant difference was not demonstrated between the 10-second and 20-second groups. These results concur with experimental evidence that benzodiazepine receptor multiplicity exists, which allows various members of the benzodiazepine group of drugs to exhibit differing therapeutic ratios for their various effects. 相似文献
76.
MD Yoshitaka Fujii 《Current therapeutic research》2005,66(4):401-408
Background:
Diazepam, a highly lipid-soluble benzodiazepine, is commonly used as a sedative agent during and after surgery. Based on a literature search, no published data are available concerning diaphragmatic function (as measured by contractility and electrical activity) during and after the administration of diazepam.Objective:
The purpose of this study was to assess the effects of diazepam use on diaphragmatic function and recovery in pentobarbital-anesthetized dogs.Methods:
This open-label, dose-finding, pharmacologic study was conductedat the Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. Healthy adult mongrel dogs weighing 10 to 15 kg were assigned to 1 of 3 study groups: low dose (0.2-mg/kg) diazepam, high-dose (0.5-mg/kg) diazepam, or control (no study drug). Each dog was anesthetized with pentobarbital 2 mg/kg · h IV Study drug was administered IV for 1 hour. Diaphragmatic function was assessed before (baseline) and at 0 (immediately after), 1, and 2 hours after the end of study drug administration, using measurement of transdiaphragmatic pressure (Pdi), defined as the difference between gastric and esophageal pressures, and by integrated electrical activity (20- and 100-Hz stimulation) of the crural (Edi-cru) and costal (Edi-cost) parts of the diaphragm. The percentage changes from baseline in Edi-cru (%Edi-cru) and Edi-cost (%Edi-cost) were calculated.Results:
Twenty-four mongrel dogs were used in the study; 8 dogs were assigned to each treatment group. During diazepam administration in the low-dose group, significant decreases from baseline in Pdi were found with 20-Hz stimulation (15.6 [1.7] vs 13.3 [1.9] cm H2O; P < 0.05) and 100-Hz stimulation (22.0 [2.1] vs 19.6 [1.8] cm H2O; P < 0.05). In the high-dose group, the decreases in Pdi were significant with 20-Hz stimulation (15.5 [1.8] vs 10.0 [2.0] cm H2O; P < 0.05) and 100-Hz stimulation (22.2 [1.9] vs 16.2 [ 2.0 ] cm H2O; P < 0.05). In the low-dose group at 100-Hz stimulation, mean (SD) %Edi-cru and %Edi-cost were significantly lower compared with baseline (88.8% [6.6%] and 88.5% [5.9%], respectively; both, P < 0.05). In the high-dose group at 100-Hz stimulation, mean (SD) %Edi-cru and %Edi-cost were significantly lower compared with baseline (77.5% [4.3%] and 78.0% [5.0%], respectively; both, P < 0.05). The decreases in Pdi, %Edi-cru, and %Edi-cost were significantly greater in the high-dose group compared with the low-dose group (all, P < 0.05).Conclusion:
The results of this experimental study of the effects of diazepamon diaphragmatic function and recovery in pentobarbital-anesthetized dogs suggest that diazepam inhibits diaphragmatic function in a dose-related manner and delays recovery. 相似文献77.
目的:探讨醒脑静注射液联合纳络酮注射液在急性安定中毒治疗中的疗效。方法:本研究采用醒脑静注射液联合纳络酮注射液治疗急性安定中毒55例并与单纯纳络酮治疗的51例进行对照。106例患者均经静脉血毒物测定为安定中毒;来诊时均有意识障碍,平均年龄(30.35±7.95)合并酒精中毒及其他疾病20例,常规给予洗胃、补液、利尿促排泄、纠正电解质失衡、吸氧及抗感染等对症处理。结果:醒脑静注射液治疗组与对照组患者比较,神志恢复时间(h),治疗组(1.73±0.98)显著短于对照组(3.22±1.38)(P<0.01);同组患者就诊时与清醒后的神志、呼吸、血压、心率及瞳孔等临床指标比较差异有显著性(P<0.05)。结论:醒脑静注射液与纳络酮联合应用,治疗急性安定中毒与对照组比较起效快、疗效确定,临床应用安全可靠。 相似文献
78.
Katsunori Tomiyama Liqiu Song Masayuki Kobayashi Anthony Kinsella Takashi Kanematsu Masato Hirata Noriaki Koshikawa John L. Waddington 《Synapse (New York, N.Y.)》2010,64(9):714-720
Orofacial movements are regulated by D1‐like dopamine receptors interacting with additional mechanisms. Phospholipase C‐related catalytically inactive protein (PRIP) regulates cell surface expression of GABAA receptors containing a γ2 subunit. Mutant mice with double knockout of PRIP‐1 and PRIP‐2 were used to investigate aspects of GABAergic regulation of orofacial movements and interactions with D1 mechanisms. Vertical jaw movements, tongue protrusions and movements of the head and vibrissae were reduced in PRIP‐1/2 double knockouts. The GABAAergic agent diazepam reduced movements of the head and vibrissae; these effects were unaltered in PRIP‐1/2 double knockouts. The D1‐like agonist SKF 83959 induced vertical jaw movements, incisor chattering, and movements of the head and vibrissae that were unaltered in PRIP‐1/2 double knockouts. However, SKF 83959‐induced tongue protrusions were reduced in PRIP‐1/2 double knockouts. PRIP‐mediated regulation of GABAAergic receptor mechanisms influences topographically distinct aspects of orofacial movement and interacts with D1 receptor systems. Synapse 64:714–720, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
79.
80.
目的 建立测定人血浆中地西泮和咪达唑仑质量浓度的高效液相色谱法.方法 色谱柱采用Waters C18柱(250 mm x4.6mm,5μm),流动相为乙腈-水(55∶45),柱温30℃,流速1.0 mL/min,检测波长220 nnl.结果 地西泮和咪迭唑仑的最低检测质量浓度为5 ng/mL,进样质量浓度的线性范围为O.05~10.0μg/mL(r>0.990 0);咪达唑仑和地西泮日内精密度的RSD分别为3.09%~5.33%和1.56%~4.25%,日间精密度的JRSD分别为4.72%~6.52%和2.59%~6.22%,方法回收率分别为94.02%~97.19%和96.07%~105.64%.结论 所用方法简便、快速、准确,适用于地西泮和咪达唑仑体内血药浓度和生物等效性的测定. 相似文献