Chemical constituents from rhizome of Anemone amurensis

Phytochemical investigation of the 70% EtOH extract of the rhizome of Anemone amurensis led to the isolation of two new oleanane-type triterpenoid saponins 1 and 2. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR data, and HR–ESI–MS. Compounds 1 and 2 were tested for cytotoxicities against two human cancer cell lines (A549 and Hep-G2). Compound 2 showed potent cytotoxicity with IC₅₀ values of 38.53 and 66.17 μM, respectively, while compound 1 with IC_50?>?100 μM.     

New cycloartane glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity

Two new cycloartane glycosides, cyprotusides A (1) and B (2), were isolated from the rhizomes of Cyperus rotundus. Their chemical structures were elucidated on the basis of IR, MS, NMR spectroscopic analyses coupled with chemical degradation. The potential antidepressant activity of the two compounds was evaluated. In the despair mice models, compounds 1 and 2 showed significant antidepressant activity.     

水杨梅属植物化学成分及其生物活性的研究进展

Ｔｈｅｒｅａｒｅａｂｏｕｔ 70ｓｐｅｃｉｅｓｉｎｔｈｅｇｅｎｕｓＧｅｕｍ ,ｏｆｔｈｅｓｅ 6ｓｐｅｃｉｅｓａｒｅｆｏｕｎｄｉｎＣｈｉｎａ[1～ 4] .Ｓｏｍｅｓｐｅｃｉｅｓ ,ｓｕｃｈａｓＧ .ａｌｅｐｐｉｃｕｍＪａｃｑ ,Ｇ .ｊａｐｏｎｉｃｕｍＴｈｕｎｂ .ａｎｄＧ .ｊａｐｏｎｉｃｕｍＴｈｕｎｂ .ｖａｒ .ｃｈｉｎｅｎｓｅＢｏｌｌｅ ,ｈａｖｅｂｅｅｎｕｓｅｄｉｎｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅａｎｄＪａｐａｎｅｓｅｆｏｌｋｍｅｄｉｃｉｎｅ .Ｔｈｅｙａｒｅａｐｐｌｉｅｄｔｏｒｅｍｏｖｅｔｏｘｉ…     

墨旱莲的生物学和化学成分研究进展

墨旱莲是我国传统的常用药材之一,近年来国内外针对墨旱莲开展了多方面的研究.现就其资源分布、营养器官和生殖器官的形态解剖、组织培养等生物学特性及其主要药用成分黄酮类、三萜皂苷、挥发油、香豆草醚类、噻吩类的研究进展进行综述,以期为墨旱莲今后的研究及应用提供参考.     

Stimulation of glucose uptake by triterpenoids from Weigela subsessilis

Four ursane‐type triterpenoids, corosolic acid (1), ilekudinol B (2), ursolic acid (3) and pomolic acid (4), were isolated from an EtOAc‐soluble extract of the leaves of Weigela subsessilis. These bioactive compounds were evaluated for their glucose uptake activity and produced moderate to strong enhancement both in basal‐ and insulin‐stimulated L6 muscle cells. In particular, corosolic acid exhibited the most potent activity, increasing uptake by basal‐ and insulin‐stimulated myotubes by 2.63‐ and 3.33‐fold, respectively; ilekudinol B produced 1.6‐ and 2.9‐fold, ursolic acid produced 1.84‐ and 2.64‐fold, and pomolic acid produced 1.6‐ and 2.8‐fold increases. No cytotoxicities were observed for corosolic acid, ursolic acid and ilekudinol B in myoblasts, while pomolic acid at doses of 25 and 50 µm reduced cell viability by 19% and 21.8% upon 24 h treatment and by 48.6% and 54.1% upon 48 h treatment, respectively. These results suggest that ursane‐type triterpenoids from W. subsessilis might enhance glucose uptake by acting as insulin mimics and as insulin sensitizers and that they could be useful as nontoxic diabetes treatment agents. Copyright © 2009 John Wiley & Sons, Ltd.     

兴安升麻根茎的化学成分研究

目的研究兴安升麻Cimicifuga dahurica根茎的化学成分。方法利用正、反相硅胶柱色谱、制备薄层色谱、Sephadex LH-20凝胶色谱等方法对兴安升麻乙醇提取物进行分离纯化,根据理化性质和波谱数据对化合物的结构进行鉴定。结果共分离得到12个化合物,分别鉴定为升麻醇(1)、异阿魏酸(2)、升麻槭素B(3)、阿魏酸(4)、升麻醇-3-O-β-D-木糖苷(5)、25-O-乙酰基升麻醇-3-O-β-D-木糖苷(6)、24-O-乙酰基-异北升麻醇-3-O-β-D-木糖苷(7)、E-3-(3″-甲基-2″-亚丁烯基)-2-吲哚酮(8)、甲基阿魏酸(9)、升麻醇-3-酮(10)、25-O-乙酰基升麻醇(11)、β-谷甾醇(12)。结论化合物9为首次从该属植物中分离得到,化合物3、7、10为首次在该植物中分离得到。     

伸筋草石松三萜化学成分

目的:研究伸筋草三萜类化学成分.方法:利用正相色谱技术结合薄层色谱法对伸筋草正丁醇层提取物进行分离纯化,并通过MS,1H-NMR,13C-NMR等现代波谱法对结构进行解析和鉴定.结果:从伸筋草中分离得到7个化合物,分别为serrat-1 4-en-3β,21α-diol(1),serrat-14-en-3β,21β-diol(2),lyeoclaninol(3),lycoclavanol(4),α-onocerin(5),16-oxo-3α-hydroxyserrat-1 4-en-21α-ol (6)β-胡萝卜苷(7).结论:其中16-oxo-3α-hydroxyserrat-14-en-21α-ol(6)、β-胡萝卜苷(7)为首次从该植物中分离得到.     

点地梅属植物化学成分与药理活性研究进展

主要从化学成分、药理活性及临床应用方面对国内外点地梅属植物研究概况进行整理,希望能够有助于点地梅属药用植物的开发和利用.借助CNKI数据库以题名或关键词为“点地梅”,PubMed以及Science Direct数据库系统以题名或关键词为“Androsace”经行检索,整理了近年来有关点地梅属植物的化学成分、药理活性及临床应用研究成果.点地梅属植物是报春花科( Primulaceae)植物中的一个大属.全世界约有100种,医药前景良好.目前,已经从点地梅属药用植物中分离得到30多种化合物,其中黄酮和三萜皂苷类为主要含有成分.体内外实验研究表明,点地梅属药用植物的粗提取物和单体化合物(三萜皂苷类成分)具有广泛的药理作用,尤其是在抗肿瘤、抗早孕和抗病毒方面效果显著.     

党参属植物化学成分及药理活性研究进展

党参Codonopsis Radix是我国常用的一种传统补益类中药,其主要含有糖类、生物碱类、聚炔类、苷类及萜类等成分,具有调节血糖、促进造血机能、抗缺氧、抗应激、抗疲劳、增强机体免疫力、延缓衰老、调节胃收缩、保护胃肠道黏膜及抗溃疡等多种药理作用。对党参属植物化学成分和药理作用方面的研究进展进行综述,为进一步开发和利用党参属植物资源提供依据。     

牛李化学成分分离鉴定

目的:研究波罗蜜属植物牛李Artocarpus nigrifolius枝条的化学成分。方法:采用硅胶,小孔树脂(MCI gel),LH-20羟丙基葡聚糖凝胶(Sephadex LH-20),ODS,HPLC等柱色谱分离手段,对牛李干燥枝条的95%乙醇提取物进行了系统的化学成分研究,根据化合物的理化性质及光谱数据鉴定其结构。结果:共分离了26个化合物,大部分为三萜类成分。包括16个三萜,2个降三萜,6个甾醇,1个苯甲醛衍生物和1个小分子胺类化合物。分别鉴定为20-hydroxy-4α,4β,14α-trimethyl-9β,19-cyclopregnane-3-one(1),1-(N-叔丁基)氨基丙酮(2),24-methylenecycloartanone(3),cyclolaudenone(4),24-methylenecycloartanol(5),4-羟基-3,5-二甲氧基苯甲醛(6),环桉烯醇(7),cycloart-23-ene-3β,25-diol(8),β-谷甾醇(9),3β,24,25-trihydroxycycloartane(10),(23E)-27-nor-3α-hydroxycycloart-23-en-25-one(11),3β-hydroxy-22,23,24,25,26,27-hexanordammarane-20-one(12),12-en-3β-hydroxy-olean-11-one(13),(24S)-cycloartane-24,25-diol-3-one(14),桦木酸(15),羽扇豆醇(16),α-香树脂醇(17),(22E)-25,26,27-trinor-3β-hydroxycycloart-22-en-24-al(18),3β-hydroxy-urs-11-en-13β,28-olide(19),11α-hydroxy-α-amyrin(20),3β-羟基豆甾-5,22-二烯-7-酮(21),7-ketositosterol(22),β-香树脂醇(23),(24S)-麦角甾-5-烯-3β,7α,二醇(24),7α-hydroxysitosterol(25)和7β-hydroxysitosterol(26)。结论:化合物1为新的环阿屯烷型C_(24)降三萜,化合物2为首次以天然产物的形式从自然界中获得,化合物6,8,11,15~17,20,22和23均为首次从波罗蜜属植物中分离得到,其余化合物均为首次从桑科植物中分离得到。三萜类成分可能为牛李的抗肿瘤活性物质基础,值得进一步深入研究。