银屑病分型论治浅解

银屑病又名牛皮癣,中医称之为白疕,是一种常见易复发的慢性炎症性皮肤病,以云母状鳞屑、红膜症、点状出血为临床特征.近年来,银屑病发病呈上升趋势,其初期有明显的季节性,呈冬重夏轻,无论男女老幼皆可发病,目前病因未明,尚缺乏有效的治疗方法.自2000年以来,我们根据银屑病的临床表现,将其辨证分型为:血热毒盛,寒湿侵袭、脉络瘀阻、血虚风燥、肝肾亏虚等五型,对证治疗取得了比较明显的疗效,现予介绍,以求同道斧正.     

无乳糖奶粉辅治轮状病毒性肠炎疗效观察

目的：探讨加用无乳糖奶粉（安儿宁）辅助治疗轮状病毒肠炎疗效。方法：将10例6月-24月、病程在3天内、以乳类喂养为主的轮状病毒肠炎患儿随机分为观察组和对照组,两组均采用抗病毒及对症支持治疗,不使用抗生素。观察组停止乳类喂养,改用无乳糖奶粉（安儿宁）;对照组继续乳类喂养,对两组病程进行比较。并将观察组随机分成A组和B组,A组腹泻停止后即停止无乳糖奶粉喂养;B组腹泻停止后继续无乳糖奶粉喂养一周。观察A、B两组腹泻复发率。结果：观察组病程平均天数为（4．10±1．33）d,对照组为（6．08±1．66）d,经统计学处理有显著性差异（t=6．95,P〈0．01）。A组复发率28％,B组复发率4％,χ^2=5．357 P〈0．05两组有显著差异。结论：加用去乳糖奶粉治疗轮状病毒肠炎可明显缩短病程。并建议于腹泻停止后继续服用无乳糖奶粉1周。     

Deep Cryogenic Treatment Characteristics of a Deformation-Processed Cu-Ni-Co-Si Alloy

This paper investigated the influence of deep cryogenic treatments (DCT) on the tensile strength, elongation to fracture and conductivity of a deformation-processed Cu-Ni-Co-Si alloy. The tensile properties were measured using a mechanical testing machine. The conductivity was evaluated using a low-resistance tester. The microstructure and precipitated phases were analyzed using scanning electron microscopy (SEM), transmission electron microscopy (TEM), an energy dispersive spectrometer (EDS) and an X-ray diffractometer (XRD). The tensile strength, elongation to fracture and conductivity of the Cu-1.34Ni-1.02Co-0.61Si alloy before and after cold rolling at 47% reduction increased with increasing DCT time and tended to be stable at about 36 h. The microstructure became more uniform after the DCT. The grain size was refined and was smallest after DCT for 48 h. The DCT promoted the precipitation of the solid solution elements Ni, Co and Si from the Cu matrix to form many fine and evenly distributed 20–70 nm spherical second-phase particles in the grains and grain boundaries.     

茵芍散对慢性乙肝湿热蕴脾证患者血清HA、IV-C水平的影响

观察茵芍散对慢性乙型肝炎湿热蕴脾证患者血清 HA、IV-C水平的影响。选择 64例慢性乙型肝炎湿热蕴脾证患者 ,随机分为 2组 ,分别在治疗前及治疗 1个月后观察各组上述指标变化。结果显示 :治疗组血清HA、IV-C含量明显降低 ,症候疗效明显改善 ,与对照组比较差异有显著性 (P<0 .0 5 )。说明茵芍散能改善血液循环 ,具有抗肝纤维化作用     

四肢周围神经主干损伤手术治疗探讨

目的 探讨几种常见四肢周围神经主干损伤的手术治疗。方法 对35例新鲜与陈旧性桡神经、尺神经、腓总神经损伤，根据不同的损伤机制，受伤时间和受损情况分别采用了神经松解术(包括神经内松解术)、神经对端吻合术、远端神经与邻近神经主干外膜“开窗”端侧吻合术、近端神经束埋置于瘫痪之肌肉内及急诊清创作神经标记、二期手术等手术方式。结果 本组35例经1．5～2年随访。本组优良率达80％。结论 四肢周围神经主干损伤致功能障碍。肢体残废，进行积极的手术治疗是唯一的办法，手术治疗是可以收到良好效果的。关键是术式的选择和早期手术。     

哮喘平冲剂对哮喘豚鼠模型肺组织形态学的影响

目的:探讨哮喘平冲剂对哮喘豚鼠模型肺组织的形态学影响。方法:采用卵蛋白致敏哮喘豚鼠模型,观察实验过程中哮喘豚鼠的一般情况及肺组织形态学变化。结果:各治疗组豚鼠的一般情况明显优于模型组,且经哮喘平冲剂治疗后哮喘豚鼠气道炎症细胞明显减少;支气管平滑肌未肥厚;哮喘平冲剂能明显改善支气管上皮损伤,粘液腺增生等病理改变。结论:哮喘平冲剂治疗哮喘的作用机理与改善肺组织形态学变化有关。     

西罗莫司纳米脂质载体固化制剂的制备

采用冷冻干燥法以微晶纤维素Avicel PH-101与聚乙烯吡咯烷酮(PVP)K30的混合物(4:1,w,%)为吸附性粉末固化西罗莫司纳米脂质载体分散液,并以再分散时间、平均粒径及分布、流动性和泄漏率等为指标,采用单因素试验优化固化处方。结果表明,3批按优化方法制备的西罗莫司纳米脂质载体固化制剂的休止角为(42.65±0.80)。,振实密度为(0.79±0.03)g/m1,且含量均匀度良好,再分散时间为(10.0±0.4)min,再分散液粒径(132.7+2.6)nm,分布系数0.297±0.01,ξ电位(-12.8±1.05)mV,冻干前后的泄漏率为(10.80±0.41)%。     

Refractoriness to bronchoconstriction following hyperventilation with cold dry air

Fifteen subjects undertook repeated periods of hyperventilation of cold dry air and hyperventilation of warm humidified air followed by cold dry air. Hyperventilation of cold dry air induced a biphasic response with initial bronchodilatation followed by bronchoconstriction. However, exercise produced a greater rise in forced expiratory volume in 1 second (FEV1) than hyperventilation alone. Hyperventilation of cold dry air resulted in a period of refractoriness to a second stress of the same type. Refractoriness induced by exercise or hyperventilation of cold dry air may be the result of refractoriness of the trigger site in the large airways.     

The mechanism of hepatic graft protection against reperfusion injury by prostaglandin E1

1 (PGE₁) on protecting against hepatic endothelial cell damage and increasing graft viability after cold preservation and reperfusion, using an isolated perfused rat liver (IPRL) model. The grafts were divided into three groups, according to the cold preservation time and PGE₁ administration, namely: 4 h preservation (group 1, n = 9), 6 h preservation (group 2, n = 9), and 6 h preservation followed by PGE₁ infusion (group 3, n = 9). After cold storage, the grafts were put on the recirculating IPRL system, then reperfused for 120 min at 37°C with oxygenated Krebs-Henseleit buffer containing hyaluronic acid (HA). To examine the function of the sinusoidal endothelial cells and hepatocytes, serial measurements of HA, tumor necrosis factor-α (TNFα), thromboxane B₂ (TXB₂), acid phosphatase, and conventional parameters in the perfusate were made. After perfusion, the trypan blue exclusion test was performed to assess the presence of any microscopic sinusoidal lining cell damage. In group 3, the bile output and HA clearance were significantly greater, while glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, TNFα, TXB₂, and acid phosphatase in the perfusate were significantly lower than in group 2. Histologically, less endothelial cell damage and hepatocyte damage than in group 2 was also confirmed. These results therefore suggest that the improvement of hepatic graft viability by PGE₁ administration is mainly due to sinusoidal endothelial cell protection. (Received for publication on Nov. 21, 1996; accepted on Nov. 6, 1998)     

促孕散治疗持久黄体奶牛血清白介素与激素的相关性分析

为探讨促孕散治疗持久黄体不孕奶牛血清生殖激素和白介素含量的关系,应用ELISA法测定了促孕散治疗持久黄体不孕奶牛前后血清中促卵泡素（FSH）、促黄体素（LH）、孕激素（P4）、雌二醇（E2）、IL-1和IL-6的浓度,分析了4种激素和2种白介素间的相关关系与回归方程。结果表明,IL-1和IL-6水平与P呈负相关,与E2、FSH、LH呈正相关,结论：促孕散治疗持久黄体奶牛前后在血清中IL-1和IL-6的变化与生殖激素的分泌具有一定的相关性。