全文获取类型
收费全文 | 125425篇 |
免费 | 10168篇 |
国内免费 | 3240篇 |
专业分类
耳鼻咽喉 | 1286篇 |
儿科学 | 7221篇 |
妇产科学 | 3818篇 |
基础医学 | 14184篇 |
口腔科学 | 1713篇 |
临床医学 | 13691篇 |
内科学 | 21041篇 |
皮肤病学 | 2401篇 |
神经病学 | 11139篇 |
特种医学 | 2821篇 |
外国民族医学 | 5篇 |
外科学 | 11790篇 |
综合类 | 18083篇 |
现状与发展 | 17篇 |
一般理论 | 1篇 |
预防医学 | 7535篇 |
眼科学 | 2380篇 |
药学 | 6457篇 |
73篇 | |
中国医学 | 11289篇 |
肿瘤学 | 1888篇 |
出版年
2024年 | 309篇 |
2023年 | 2102篇 |
2022年 | 4240篇 |
2021年 | 6060篇 |
2020年 | 5548篇 |
2019年 | 4371篇 |
2018年 | 4433篇 |
2017年 | 4598篇 |
2016年 | 4683篇 |
2015年 | 4444篇 |
2014年 | 8606篇 |
2013年 | 9000篇 |
2012年 | 7078篇 |
2011年 | 8268篇 |
2010年 | 6373篇 |
2009年 | 6162篇 |
2008年 | 6002篇 |
2007年 | 6142篇 |
2006年 | 5555篇 |
2005年 | 4638篇 |
2004年 | 3969篇 |
2003年 | 3534篇 |
2002年 | 2469篇 |
2001年 | 2208篇 |
2000年 | 1923篇 |
1999年 | 1764篇 |
1998年 | 1454篇 |
1997年 | 1369篇 |
1996年 | 1307篇 |
1995年 | 1254篇 |
1994年 | 1061篇 |
1993年 | 959篇 |
1992年 | 856篇 |
1991年 | 671篇 |
1990年 | 628篇 |
1989年 | 507篇 |
1988年 | 514篇 |
1987年 | 464篇 |
1986年 | 411篇 |
1985年 | 525篇 |
1984年 | 437篇 |
1983年 | 282篇 |
1982年 | 354篇 |
1981年 | 322篇 |
1980年 | 260篇 |
1979年 | 212篇 |
1978年 | 133篇 |
1977年 | 104篇 |
1976年 | 86篇 |
1975年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
Masato Tsukahara Takahiro Okabe Morimasa Ohtsuka Susumu Furukawa 《American journal of medical genetics. Part A》1995,57(3):444-446
We report on an 8-year-old Japanese boy with Setleis syndrome. The patient had a very characteristic “coarse” facial appearance, bitemporal “forceps marks,” skin aplasia, sparse hair, and skin hypo- and hy-perpigmentation. He also had previously undescribed manifestations, including an aberrant hair pattern of the forehead, linear skin lesions on the forehead, short palpebral fissures, a small skin tag on the right cheek, cone-shaped teeth, and pectus carinatum. Dermatoglyphic studies documented aberrant distal palmar creases (simian crease variant), 8 arches, and reduced total finger ridge count. When serial photographs were reviewed, his facial characteristics became more obvious with increasing age. © 1995 Wiley-Liss, Inc. 相似文献
942.
Production of tumour necrosis factors by human T cells stimulated by a superantigen,toxic shock syndrome toxin-1
下载免费PDF全文
![点击此处可从《Clinical and experimental immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
H. AKATSUKA K. IMANISHI K. INADA H. YAMASHITA M. YOSHIDA T. UCHIYAMA 《Clinical and experimental immunology》1994,96(3):422-426
The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-α and TNF-β) upon stimulation with toxic shock syndrome toxin-l (TSST-I) and the requirement for MHC ctass II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was much higher than that of CD8+ T cells in TSST-1-induced production of TNF-α and TNF-β. The expression of MHC class II molecules on AC was required in the response. 相似文献
943.
Isao Nishimori Kazuichi Okazaki Yasuro Yamamoto Masanori Morita Satoru Tamura Yasutake Yamamoto 《Journal of clinical immunology》1993,13(4):265-271
The specific cellular immune response to the partially purified pancreatic antigen was studied by the peripheral blood lymphocyte proliferation assay in patients with chronic pancreatitis, Sjögren's syndrome, and primary biliary cirrhosis. A significant positive result (stimulation index >2.0) was observed in 7 of 21 patients with idiopathic chronic pancreatitis (33%;P<0.05), 6 of 7 patients with Sjögren's syndrome-associated chronic pancreatitis (86%;P<0.0005), and 6 of 11 patients with Sjögren's syndrome (55%;P<0.01), compared to normal controls whose stimulation index was 0.94±0.28 (mean ± SD;n=14; range, 0.56–1.60). On the other hand, patients with alcoholic chronic pancreatitis (17%;n=12), stone-related chronic pancreatitis (0%;n=7), primary biliary cirrhosis-associated chronic pancreatitis (33%;n=3), primary biliary cirrhosis (0%;n=4), systemic lupus erythematosus (17%;n=6), and autoimmune thyroiditis (0%;n=6) showed no significant difference from normal controls. Furthermore, in patients with idiopathic chronic pancreatitis who had positive results, a lymphocyte proliferative response to the pancreatic antigen was observed in T cells, especially in the CD4+ T cell subpopulation. These results suggest that the pancreatic antigen plays a role in the pathogenesis of a part of idiopathic chronic pancreatitis and Sjögren's syndrome in association with T cell responses and, also, suggest that autoimmunity may be a possible etiological factor in chronic pancreatitis. 相似文献
944.
Israel Shapiro Zvi Borochowitz Shimon Degani Hanna Dar Izu Ibschitz Mordechai Sharf 《American journal of medical genetics. Part A》1992,43(3):602-605
A diagnosis of the Neu-Laxova syndrome (NLS) was made by ultrasonography at 32 wks of gestation. Ultrasonographic examination showed intrauterine growth retardation (IUGR), Dandy-Walker anomaly, choroid plexus cysts, receding forehead and microcephaly, bilateral cataract without prominent eyes, scalp edema with no generalized edema, retrognathia, curved penis, and flexion deformities of limbs. The findings in this case are consistent with NLS; however, they did not fit any of Curry's [1982] groups. Massive swelling of hands and feet were among the main manifestations in classic NLS cases. In the case presented herein, edema was noted only in the scalp. This might shed further light on the question of variability vs. heterogeneity in the NLS. This case shows the existing possibility of an early diagnosis of NLS and adds Dandy-Walker anomaly and choroid plexus cysts as new findings to this syndrome. © 1992 Wiley-Liss, Inc. 相似文献
945.
946.
947.
1988年至1991年对收治的发病5日以内的肾综合征出血热(HFRS)病人应用姬鼠型HFRSV陈株及家鼠型HFRSVR22株,免疫猪所制备的特异性双价纯化免疫血清F(ab)2(称F(ab)2血清),治疗HFRS病人65例作为研究组,以44例作为对照组。治疗结果表明:①球结膜水肿渗出减轻,24小时出血减轻;②白细胞病毒抗原消失迅速;③研究组出院平均早9.1天;④在洽疗后2、4日,对照组的特异性免疫荧光IgM抗体明显高于研究组的。⑤其他实验室检测指标都以研究组为优。提纯后的免疫血清F(ab)2无抗体-介导反应,无副作用及过敏反应。它含有特异性中和抗体及其他免疫因子,可中和清除体内的病毒抗原,减轻病毒血症及毛细血管壁的损伤,阻断病情发展,促进病情恢复。 相似文献
948.
Children seen in a multispecialty medical clinic for abdominalpain were divided into three groups: 21 with confirmed organicfindings related to the abdominal pain, 14 with confirmed organicfindings unrelated to the pain, and 108 whose physical examinationswere negative (the functional pain group). For children withfunctional abdominal pain (but not for the others) the numberof symptoms of somatization disorder (Briquet's syndrome) wassignificantly related to the chronicity of the child's condition.Children with functional pain and no prior complaint had a meanof 1.95 symptoms; those with complaints of less than 1 year'sduration, 2.21 symptoms; those with complaints of more thana year since age 6, 4.04 symptoms; and those with complaintsfor more than a year with onset prior to age 6 years, 4.55 symptomsfrom the Somatization Disorder list. Findings were interpretedas preliminary evidence for a distinct, chronic, polysymptomatichysterical disorder beginning in childhood. 相似文献
949.
Klinefelter syndrome is a common cause for mental retardation of unknown etiology among prepubertal males 总被引:1,自引:0,他引:1
Klinefelter syndrome (KS) has not typically been associated with mental retardation (MR), however, in recent years a growing body of evidence suggested that KS boys often experience language deficits and academic difficulties. In this study, we screened DNA samples from 1205 patients originally referred for fragile X syndrome (FRAX) testing, because of MR of unknown etiology and detected 8 KS patients. A similar number of males in the same age group were found to have FRAX; 3 of them had a family history of FRAX. Based on these findings, KS might be the most common cause of MR of unknown etiology among prepubertal males. Because of the significant benefits of early recognition and treatment of KS, we emphasize the importance of cytogenetic testing of all prepubertal males with cognitive impairment even without dysmorphic features. 相似文献
950.
Sleep apnea-related cognitive deficits and intelligence: an implication of cognitive reserve theory 总被引:3,自引:0,他引:3
Alchanatis M Zias N Deligiorgis N Amfilochiou A Dionellis G Orphanidou D 《Journal of sleep research》2005,14(1):69-75
Cognitive deficits in patients with obstructive sleep apnea syndrome (OSAS) are well demonstrated, but the pathophysiology of these deficits is still controversial, as the relationship between OSA severity and cognitive deficits is usually weak. Our study considers the possible relationship between OSA-related cognitive deficits and the overall intellectual function of OSA patients. Forty-seven OSA patients and 36 normal individuals underwent a neuropsychological battery test assessing attention and alertness. According to the resulting IQ score, patients and controls were divided into a high-intelligence group (IQ > or = 90th percentile) and a normal-intelligence group (50 < or = IQ < 90%ile). Between the two patient groups there were no significant differences noticed, regarding OSA severity or sleepiness. High-intelligence patients showed the same attention/alertness performance compared with the high-intelligence controls. On the contrary, patients with normal-intelligence showed attention/alertness decline compared with the normal-intelligence control group. The two patient groups were re-examined with the same battery test after at least 1 year of CPAP treatment. At re-examination neither patient group showed any differences regarding attention and alertness compared with the control groups. We assume that high-intelligence may have a protective effect against OSA-related cognitive decline, perhaps due to increased cognitive reserve. 相似文献