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81.
Tae Kyung Hyun Sang Churl Song Chang-Khil Song Ju-Sung Kim 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2015,23(4):742
The fruit of Sageretia theezans is one of many underutilized edible fruits that grow along the southern seashores of East Asia. In this study, to evaluate the nutritional and nutraceutical values of S. theezans fruit, the composition of minerals, organic acids, and proximate and fatty acids, the total phenolic, total flavonoid, and total anthocyanin content, and the antioxidant and antidiabetic activities of S. theezans fruit were analyzed. The results indicate that S. theezans fruit could be classified as a potential potassium-, malic acid-, and linoleic/oleic acid-rich fruit. In addition, The ethyl acetate (EtOAc) fraction of the 70% ethanol (EtOH) crude extract exhibited strong antioxidant activities including free radical scavenging and reducing power activities compared with the same concentration of butylated hydroxytoluene. Furthermore, the EtOAc fraction showed significant inhibition of α-glucosidase activity. The analysis of the total phenolic and flavonoid content suggested that the remarkable antioxidant and antidiabetic activities of the EtOAc fraction are due to the presence of high levels of polyphenolic compounds. 相似文献
82.
Gozde Hasbal Tugba Yilmaz-Ozden Ayse Can 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2015,23(1):57
In this study, the antioxidant and antiacetylcholinesterase activities of Sorbus torminalis (L.) Crantz fruits were evaluated. Total phenolic and flavonoid compounds, 2,2′-azino-bis (3-ethylbenzothioazoline-6-sulfonic acid), 2,2′-diphenyl-1-picrylhydrazyl, and superoxide anion radicals scavenging activities and ferric-reducing antioxidant power of water, ethyl acetate, acetone, and methanol extracts were determined for the measurement of the antioxidant activity. Quercetin and α-tocopherol were used as standard antioxidants. The inhibitory effect of the water extract on acetylcholinesterase (AChE) was evaluated using the Ellman method and galantamine was used as a standard. Water extract had the highest total phenolic concentration and the strongest antioxidant activity followed by ethyl acetate and acetone extracts whereas methanol extract has the lowest phenolics and weakest antioxidant activity. Moreover, water extract showed moderate ability to inhibit AChE. It was concluded that fruits of S. torminalis have antioxidant and anti-AChE activities and that the plant might be a natural source of antioxidants and AChE inhibitors. 相似文献
83.
Ins Mndez-Tovar Baudilio Herrero Silvia Prez-Magario Jos Alberto Pereira M. Carmen Asensio-S.-Manzanera 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2015,23(2):225
The objective of this work was to evaluate the antioxidant properties of Lavandula latifolia waste obtained after essential oil distillation. Samples of 12 wild populations of the Lavandula genus collected between 2009 and 2010 were hydrodistilled and their by-products were analyzed using the Folin–Ciocalteu, free radical scavenging activity (2,2-diphenyl-1-picrylhydrazyl), and the ferric reducing antioxidant power (FRAP) methods. Rosmarinic acid, apigenin, and luteolin contents were analyzed by high-performance liquid chromatography–diode array detection. The mean of total phenolic content ranged from 1.89 ± 0.09 mg gallic acid equivalents/g dry weight to 3.54 ± 0.22 mg gallic acid equivalents/g dry weight. The average value of the half maximal effective concentration (EC50) for scavenging activity ranged from 5.09 ± 0.17 mg/mL to 14.30 ± 1.90 mg/mL and the variability of the EC50 in FRAP ranged from 3.72 ± 0.12 mg/mL to 18.55 ± 0.77 mg/mL. Annual variation was found among this samples and the environmental conditions of 2009 were found to be more favorable. The plants collected from Sedano showed the highest antioxidant power. Our results show that rosmarinic acid and apigenin in L. latifolia contributed to the antioxidant properties of the waste. In conclusion, the by-product of the distillation industry could be valorizing as a source of natural antioxidants. 相似文献
84.
Background:This study aims to assess the therapeutic effects of a well-known component (puerarin) obtained from a Chinese herb root in patients with polycystic ovary syndrome (PCOS).Methods:Women with premature ovarian failure (POF) were assigned to the obese group (body mass index [BMI] ≥24 kg/m2 and waist hip ratio [WHR] >0.85) or non-obese group (group 3, n = 21). Obese patients were further randomly assigned to the obese treatment group (group 1, n = 15) and obese control group (group 1, n = 15). All patients received standard treatment (Diane-35, 1 tablet/d, orally, plus metformin, 1.5 g/d, orally). In addition to the standard modality, patients in group 1 and group 3 also orally received 150 mg/d of puerarin tablets for 3 months. Venous blood was drawn before and after treatment. Then, the metabolic and antioxidant biomarkers were measured. The normality of distribution of the data was tested using the Kolmogorov–Smirnov method. The baseline characteristics were analyzed using one-factor analysis of variance (ANOVA), and post-hoc was performed using the least significance difference (LSD)-t test.Results:Significantly improved blood levels of sex hormone binding globulin (SHBG) and superoxide dismutase (SOD) were observed in patients who received the additional treatment of puerarin, regardless of their lean or obese status, while these were not observed in patients who did not receive puerarin. Furthermore, obese patients with PCOS had significantly lower systolic blood pressure, total cholesterol, and testosterone blood levels, when compared with before treatment.Conclusion:The addition of puerarin to the present treatment protocol can be considered for the management of metabolic disorders and hyperandrogenism in PCOS patients. 相似文献
85.
Somayeh Shahani Mostafa Rostamnezhad Vahid Ghaffari-rad Arash Ghasemi Tayyeb Allahverdi Pourfallah Seyed Jalal Hosseinimehr 《Dose-response》2015,13(1)
The radioprotective effect of Achillea millefolium L (ACM) extract was investigated against genotoxicity induced by ionizing radiation (IR) in human lymphocytes. Peripheral blood samples were collected from human volunteers and incubated with the methanolic extract of ACM at different concentrations (10, 50, 100, and 200 μg/mL) for 2 hours. At each dose point, the whole blood was exposed in vitro to 2.5 Gy of X-ray and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cell. Antioxidant capacity of the extract was determined using free radical-scavenging method. The treatment of lymphocytes with the extract showed a significant decrease in the incidence of micronuclei binucleated cells, as compared with similarly irradiated lymphocytes without any extract treatment. The maximum protection and decrease in frequency of micronuclei were observed at 200 μg/mL of ACM extract which completely protected genotoxicity induced by IR in human lymphocytes. Achillea millefolium extract exhibited concentration-dependent radical-scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals. These data suggest that the methanolic extract of ACM may play an important role in the protection of normal tissues against genetic damage induced by IR. 相似文献
86.
Kouoh F Gressier B Dine T Luyckx M Brunet C Ballester L Cazin JC 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2002,16(6):515-520
Activated neutrophils which produce certain proteases, such as elastase and reactive oxygen species (ROS) are involved in oxidative stress and inflammation. In the present study, we have shown that nicardipine, a calcium channel blocker, affects the release of elastase and superoxide anion radicals (O2
–) in vitro during human and rabbit neutrophil respiratory bursts. The drug inhibited the release of elastase and O2
– by fMLP (N-formyl-methionylleucin-phenylalaninin), calcium ionophore (A23187) and PMA (phorbol-myristate-acetate)-stimulated human and rabbit neutrophils. Besides the release of elastase, strongly inhibited in the fMLP and A23187 stimulated systems, nicardipine affected elastase and O2
– in a dose-dependent manner. The corresponding 50% inhibitory concentration (IC50) of nicardipine for elastase, released in PMA-stimulated human and rabbit neutrophils, was 15.95 ± 0.17 M and 18.06 ± 0.08 M, respectively, whereas for O2
–, the IC50 of nicardipine in PMA, fMLP and A23187-stimulated human and rabbit neutrophils was 55.41 ± 0.09 M and 58.43 ± 0.03 M, 45.21 ± 0.13 M and 37.19 ± 0.53 M, 33.54 ± 0.09 M and 30.54 ± 0.29, respectively. The mechanisms underlying the inhibition of elastase and superoxide anion radicals by nicardipine appear related to an inhibiting effect on the mobilisation of cytosolic calcium and on activation of protein kinase C (PKC). These antioxidant and anti-elastasic activities contribute to the properties of nicardipine, as positive side effects of its antihypertensive activity and may be useful to prevent inflammatory disorders (tissue damage, oxidative injury) involved in the pathogenesis of hypertension. 相似文献
87.
88.
目的 建立最佳的甘草抗氧化活性成分闪式提取工艺.方法 应用多指标综合评分法,结合正交试验设计,以甘草总黄酮含量、DPPH自由基清除率和浸膏得率的综合评分为指标,考察甘草抗氧化活性成分闪式提取工艺.结果 最佳闪式提取工艺为90%乙醇,固液比1∶20(g/mL),提取次数3次,每次2min.结论 该工艺提取时间短、提取效率高,是一种简单、快速、实用的甘草抗氧化活性成分提取方法. 相似文献
89.
90.
Hye Jin Han Un Ju Jung Hye-Jin Kim Byoung Seok Moon Su-Jung Cho Yong Bok Park Dong Gun Lee Myung-Sook Choi 《Nutrition Research And Practice》2015,9(3):227-234