电动微针联合中药提取物在中重度雄激素性脱发长期治疗中的效果

目的 观察电动微针联合中药提取物在中重度雄激素性脱发长期治疗中的效果。方法 选取2019年 12月-2022年5月我院皮肤科收治的80例中重度雄激素性脱发患者为研究对象,根据随机数字表法分为观 察组（n=40）和对照组（n=40）。对照组给予电动微针治疗,观察组在对照组基础上加用中药提取物治 疗,比较两组中医症候积分及临床疗效。结果 观察组治疗总有效率为95.00%,高于对照组的80.00%（P ＜0.05）;观察组治疗后各项中医症候积分均低于对照组（P＜0.05）。结论 应用电动微针联合中药提取物 治疗能有效改善患者的临床症状,同时保障治疗的有效性,值得临床应用。     

皮质类固醇激素治疗顽固性斑秃的疗效评价

目的　评价得宝松皮损内注射及甲基强的松龙静脉内冲击治疗顽固性多灶性斑秃的疗效。方法　对 2 3例病程在 13个月至 6年的斑秃患者 ,于皮损内注射得宝松 (0 .1ml/cm2 ) ,治疗结束 2个月后判定疗效 ,对得宝松治疗无效的病例 ,予甲基强的松龙冲击治疗 ,5 0 0mg/日 ,每月静滴 3天 ,连续治疗 3个月。结果　得宝松治疗组痊愈及显效病例为 11例 (4 7.83 % ) ,甲基强的松龙组痊愈及显效病例为 4例 (5 7.14% )。结论　皮损内注射得宝松及甲基强的松龙静脉内冲击治疗对病程至少是 13个月的顽固性多灶性斑秃患者 ,有较好的疗效 ,对其他治疗手段抵抗的病例 ,只要掌握好适应证 ,皮质类固醇激素冲击治疗也是一种有效的治疗方法     

从脾肾论治脂溢性脱发

脂溢性脱发好发部位多为头顶、前额两侧等处.此病多发于青壮年男性,近年来发现女性患者人数有增加的趋势.中医认为,脂溢性脱发,其病位在发与肾,而与脾关系密切,当针对其湿热内盛,邪气循经上传,侵蚀发根毛囊以及阻遏肾中精血滋养发根毛囊的病机特点,采用清热利湿、活血通络、补肾填精等治法,内外合治,方能收到较好的治疗效果.     

人毛乳头细胞条件培养液治疗斑秃的临床观察

目的：人毛乳头细胞条件培养液治疗斑秃患者的临床观察。方法：用人毛乳头细胞条件培养液治疗100例斑秃患者，并分别选择其中53例和30例作去炎松组和空白组自身对照。结果：人毛乳头细胞条件培养液组、去炎松组和空白组治愈率分别为75％、51％、10％，有效率分别为97％、72％、30％，人毛乳头细胞条件培养液组其治愈率和有效率均明显高于去炎松组和空白组（P〈0．05）。结论：人毛乳头细胞条件培养液对斑秃患者有明显的治疗作用。     

人毛乳头细胞条件培养液对斑秃患者的治疗作用

目的:观察人毛乳头细胞(DPC)条件培养液对斑秃患者的治疗作用,探讨DPC分泌促进毛囊生长的活性物质。方法:收集体外培养低传代DPC培养上清,制成冻干粉,用于治疗50例斑秃患者,并分别选择其中26例和10例作去炎松组和空白组自身对照。结果:DPC条件培养液组、去炎松组和空白组治愈率分别为74%、54%、10%,有效率分别为96%、73%、30%,DPC条件培养液组其治愈率和有效率均明显高于去炎松组和空白组(P<0.01)。结论:人DPC条件培养液有促进斑秃患者毛囊生长的作用。     

穴位放血疗法联合微针配合米诺地尔治疗进展期雄激素性秃发疗效分析

目的:探讨穴位放血疗法联合微针配合米诺地尔治疗进展期雄激素性秃发的疗效。方法:将2016年1月-2018年1月笔者科室门诊收治的85例男性进展期雄激素性秃发患者随机分成两组,联合组(放血疗法联合微针配合米诺地尔)43例和对照组(微针配合米诺地尔)42例。比较两组患者治疗3个月、6个月后的疗效、毛发密度及血清睾酮(T)、双氢睾酮(DHT)、性激素结合球蛋白(SHBG)及游离睾酮(FT)水平,比较两组患者停药后的复发情况及治疗期间出现的不良反应。结果:治疗3个月、6个月后,联合组患者总有效率均明显高于对照组,终毛密度与总毛发密度均明显高于对照组(P<0.05),毳毛密度与对照组患者相比,差异无统计学意义(P>0.05);治疗3个月、6个月后,联合组患者DHT、FT水平比对照组明显降低,SHBG水平比对照组明显升高(P<0.05);T水平与对照组相比,差异无统计学意义(P>0.05);停药12个月后,联合组患者的总复发率低于对照组患者(P<0.05),联合组患者治疗期间不良反应发生率低于对照组患者(P<0.05)。结论:穴位放血疗法联合微针配合米诺地尔治疗进展期雄激素性秃发患者疗效确切,不仅可以明显增加患者头发密度、降低复发率,还可以平衡患者的性激素,且安全性高。     

Cardiofaciocutaneous (CFC) syndrome

An 11-year-old boy affected by mental retardation and seizures demonstrates congenital heart defect, many dysmorphic features and dry skin. His hair is sparse over the vertex with alopecia of the eyebrows and eyelashes. There are horny small papules evident in those areas. The diagnosis of cardiofaciocutaneous syndrome has been made. The relationship between cardiofaciocutaneous and Noonan syndrome is discussed.     

Androgenetic alopecia in children: report of 20 cases

Androgenetic alopecia (AGA) is the most common type of hair loss in adults. Although there are differences in the age at onset, the disease starts after puberty when enough testosterone is available to be transformed into dihydrotestosterone. We report 20 prepubertal children with AGA, 12 girls and eight boys, age range 6-10 years, observed over the last 4 years. All had normal physical development. Clinical examination showed hair loss with thinning and widening of the central parting of the scalp, both in boys and girls. In eight cases frontal accentuation and breach of frontal hairline were also present. The clinical diagnosis was confirmed by pull test, trichogram and dermoscopy in all cases, and by scalp biopsy performed in six cases. There was a strong family history of AGA in all patients. The onset of AGA is not expected to be seen in prepubertal patients without abnormal androgen levels. A common feature observed in our series of children with AGA was a strong genetic predisposition to the disease. Although the pathogenesis remains speculative, endocrine evaluation and a strict follow-up are strongly recommended.     

Hair restoration approaches for early onset male androgenetic alopecia

Society places great emphasis on the presence of hair. Some degree of hair loss is accepted as a normal part of the aging process, in line with the observation that more than 50% of men will develop androgenetic alopecia by the age of 50 years. However, it is possible to understand the psychosocial isolation and distress felt by men with a strong familial predisposition to androgenetic alopecia, who tend to display hair loss in their late teens or twenties. There are currently two drugs which have been licensed for the treatment of male androgenetic alopecia: oral finasteride and topical minoxidil solution which are effective to some extent. Furthermore, upon discontinuing treatment, any gain that has been achieved is quickly lost. Added to which there is an entire market of unproven over the counter products: advertised in the electronic media, local hair salons, and various departmental stores. In this review, we highlight the important advances in the management of male androgenetic alopecia with emphasis on approaches that can lead to more successful and long‐term hair restoration for young adults. In particular, we discuss the evidence supporting the use of the follicular unit grafting technique in conjunction with medical treatment before and after the procedure. Moreover, some other alterations of this most popular state of the art hair restoration technique have been mentioned briefly. As a result, patients and physicians seem equally satisfied from this procedure for its naturally looking results which are cosmetically more acceptable and esthetically pleasing for longer period of time.