中西医结合微创治疗粘连性肠梗阻

目的：探索中西医结合与微创技术联合治疗粘连性肠梗阻的疗效。方法：31例粘连性肠梗阻，在急性期以中西医结合疗法辨证施治，解除急性梗阻；梗阻缓解后行腹腔镜粘连松解术，预防梗阻复发。结果：急性期经中西医结合治疗，肠梗阻均解除。缓解期行腹腔镜粘连松解术，成功26例（83．9％）；中转开腹手术5例（16．1％）。腹腔镜粘连松解术后胃肠功能恢复时间0．5－2d；术后住院时间2－4d。26例腹腔镜粘连松解术后随访（3个月－3年），均无肠梗阻复发的表现。结论：中西医结合微创治疗粘连性肠梗阻中转开腹率较低，并发症发生率低，术后效果好，无梗阻再发。     

小肠内固定术治疗粘连性肠梗阻

目的评价小肠内固定术治疗粘连性肠梗阻的疗效。方法回顾性分析28例粘连性肠梗阻行小肠内固定术患者的临床资料。结果28例患者中有5例发生切口感染,无手术死亡和小肠瘘发生。其中25例患者平均随访23.6个月,1例肠梗阻复发,保守治疗后好转。结论小肠内固定术是治疗预防粘连性肠梗阻可行、有效的方法,但需要注意手术操作细节。     

小切口联合粘贴式负压冲吸器在直肠肛管周围脓肿治疗中的应用

目的探讨小切口联合粘贴式负压冲吸器治疗直肠肛管周围脓肿的效果。方法将我科2007年2月至2010年9月收治的362例直肠肛管周围脓肿患者随机分两组,183例（实验组）采用小切17联合粘贴式负压冲吸器治疗,179例（对照组）采用切开引流治疗,对比两种方法治疗效果。结果两组在治愈率差异无统计学意义（P〉0．05）,但实验组缩短手术时间及住院时间,缩小手术切口长度,并降低术后疼痛评分,与对照组比较差异有统计学意义（P〈0．05）。结论在直肠肛管周同脓肿治疗中,小切口联合粘贴式负压冲吸器具有手术时间及住院时间短、创伤小、术后疼痛轻的特点,具有较高的临床应用价值。     

腹腔镜治疗粘连性肠梗阻42例报告

目的:探讨腹腔镜下肠粘连松解术治疗粘连性肠梗阻的可行性及疗效。方法:总结2001年1月至2007年12月42例粘连性小肠梗阻患者行腹腔镜粘连松解术,并配合留置医用生物蛋白胶或透明质酸钠防止再粘连的临床资料。结果:40例应用腹腔镜成功实施粘连松解术,未出现手术并发症和过敏现象,随访3~36个月,无肠梗阻症状复发;2例中转开腹。结论:腹腔镜肠粘连松解术配合生物蛋白胶治疗粘连性肠梗阻安全实用,疗效满意,是处理粘连性肠梗阻的有效手段之一。     

经肛肠梗阻导管在左半结直肠肿瘤切除中的应用

目的：探讨腹腔镜联合经肛肠梗阻导管在左半结直肠肿瘤急性梗阻中的治疗价值。方法：将126例左半结直肠肿瘤急性梗阻病例随机分为2组,治疗组应用经肛肠梗阻导管行梗阻近段结肠减压、灌洗等治疗后,行腹腔镜手术并一期切除吻合;对照组按常规准备后手术治疗。结果：术后吻合口瘘发生率治疗组（1.6%）低于对照组（11.1%）,治疗组住院时间、总住院费用和术后第7 d血清白蛋白水平与对照组比较有显著性差异（P＜0.01）。结论：腹腔镜联合肠梗阻导管置入冲洗减压,在左半结直肠肿瘤急性梗阻中的应用安全、有效。     

A comparison of three methods of skin closure following repair of Achilles tendon rupture

Meticulous skin closure is required to avoid wound problems after Achilles tendon surgery. The purpose of our study was to compare postoperative complication rate, operation time, clinical outcome and patient satisfaction with the wound among two topical skin adhesives (2-octyl cyanoacrylate and n-butyl cyanoacrylate) and conventional nylon skin sutures in Achilles tendon repair surgery. We retrospectively reviewed the records 122 consecutive patients (40 patient in nylon skin suture, 43 patients in 2-octyl cyanoacrylate and 39 patients in n-butyl cyanoacrylate) who underwent surgical repair for acute Achilles tendon rupture between 2012 and 2016. The primary outcome measure was the development of complications in the wound. Secondary outcome measures included the operative time, the Achilles Tendon Total Rupture Score (ATRS) and patient satisfaction with the wound. There was no difference in complication rate in the wound (p = 0.694) and in ATRS (p = 0.824) among patients in the three groups. Mean operative time in nylon skin suture group was significantly longer than in the 2-octyl cyanoacrylate group and n-butyl cyanoacrylate group (p = 0.018 and p = 0.002, respectively). Patient satisfaction in the 2-octyl cyanoacrylate and n-butyl cyanoacrylate groups was significantly higher than in the nylon skin suture group (p = 0.015 and 0.018, respectively). The use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives for skin closure following repair of Achilles tendon rupture has equivalent effectiveness and safety compared to conventional nylon skin suture, but higher patient satisfaction. Despite its higher cost, these topical skin adhesives are viable alternatives for wound closure in patients who regard cosmetic outcomes as important.     

开腹腹部手术延迟性术后肠麻痹的危险因素分析

目的 旨在研究首都医科大学附属北京友谊医院腹部手术后延迟性肠麻痹（prolonged postoperative ileus,PPOI）危险因素。方法 纳入2016年7月至2017年12月间于首都医科大学附属北京友谊医院普外科接受开腹消化道肿瘤根治术的患者123例为研究对象。以出现PPOI为病例组（13例）,其余为对照组（110例）。采用单因素和多因素Logistic回归模型分析PPOI的危险因素。结果 单因素分析显示体质量指数（body mass index,BMI）（χ²=6.824,P=0.009）、术后出现低钾血症（χ²=3.872,P=0.049）与PPOI发生相关。多因素Logistic回归分析结果示BMI<18.5 kg/m²是PPOI发生的独立危险因素。结论 BMI是PPOI的独立危险因素,当BMI<18.5 kg/m²,发生术后延迟性肠麻痹的危险性增加。     

舒敏之星导入绽妍安亦佳重组贻贝粘蛋白膏体敷料治疗面部激素依赖性皮炎的临床疗效

评价舒敏之星皮肤治疗仪导入重组贻贝粘蛋白膏体敷料治疗面部激素依赖性皮炎的临床效果及安全性。方法 选取2022年3月-2023年3月烟台市农科院中医皮肤病医院收治的67例面部激素依赖性皮炎患者为研究对象,按照随机数字表法分为对照组（n =33）和观察组（n =34）。对照组采用常规药物治疗,观察组在对照组基础上采用舒敏之星导入重组贻贝粘蛋白膏体敷料治疗,比较两组治疗前后临床症状评分、瘙痒评分、临床疗效及生活质量,并随访3个月,观察两组复发情况。结果 两组治疗后皮损面积评分、红斑评分、脱屑评分均优于治疗前,且观察组优于对照组（P ＜0.05）;两组治疗后瘙痒评分优于治疗前,且观察组优于对照组（P ＜0.05）;观察组治疗总有效率为94.12%,高于对照组的75.76%（P ＜0.05）;观察组各项生活质量评分高于对照组（P ＜0.05）;观察组复发率为8.82%,低于对照组的36.36%（P ＜0.05）。结论 舒敏之星联合重组贻贝粘蛋白膏体敷料可有效改善面部激素依赖性皮炎症状,并修复受损的皮肤屏障,具有临床疗效好、安全性高的特点,值得临床应用。     

Magnetic Resonance Imaging of Adhesive Capsulitis: Correlation with Clinical Staging

The purpose of this study was to evaluate non-contrast magnetic resonance imaging (MRI) findings of adhesive capsulitis and correlate them with clinical stages of adhesive capsulitis. This will hopefully define a role for shoulder MR imaging in the diagnosis of adhesive capsulitis as well as in potentially directing appropriate treatment. Forty-seven consecutive non-contrast magnetic resonance imaging examinations of 46 patients with a clinical diagnosis of adhesive capsulitis were retrospectively reviewed and correlated with clinical staging. Specific MRI criteria correlated with the clinical stage of adhesive capsulitis, including the thickness and signal intensity of the joint capsule and synovium as well as the presence and severity of scarring in the rotator interval. Routine MRI of the shoulder without intraarticular administration of gadolinium can be used to diagnose all stages of adhesive capsulitis, including stage 1, where findings may be subtle on clinical examination. We believe that future studies assessing the role of MRI in guiding the initiation of appropriate treatment should be undertaken.     

Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation

INTRODUCTION: Lipopolysacharide (LPS) causes gastrointestinal ileus and gastric luminal fluid accumulation. Ketamine, an anti-inflammatory anesthetic agent attenuates accumulation of luminal fluid. However, its effects on gastrointestinal transit induced by endotoxemia are unknown. The purpose of this study was to determine if the anti-inflammatory properties of ketamine improve impaired gastric emptying and gastrointestinal transit because of LPS. MATERIALS AND METHODS: Rats were given ketamine (70 mg/kg i.p.) or saline 1 h before LPS (20 mg/kg, i.p.) or saline injection. Five hours after LPS injection, rats were gavaged with 1 cc consisting of 0.1 ml of 5 mm FITC Dextran added to 0.9 ml of saline. After 30 min, rats were sacrificed, and gastric emptying, gastrointestinal transit, and gastric fluid accumulation determined. Gastric and ileal mucosa were harvested for analysis of inducible nitric oxide synthase (iNOS) (Western immunoblot). Results are reported as mean +/- SE (n > or = 5 per group; ANOVA). RESULTS: Ketamine did not prevent LPS induced gastrointestinal ileus, nor did it improve gastric emptying. More importantly, it did not worsen gastrointestinal function or gastric emptying when compared to saline controls. However, it did decrease LPS induced gastric luminal fluid accumulation and blunted iNOS expression in both the stomach and ileum. CONCLUSION: These data indicate that the ability of ketamine to attenuate gastric fluid accumulation is not because of improved gastric emptying or improved gastrointestinal transit. Moreover, while iNOS may play a role in LPS induced gastric luminal fluid accumulation, it does not appear to be a major mediator of the gastrointestinal ileus caused by LPS.