三豆败毒散治疗顽固性痤疮随机平行对照研究

[目的]观察三豆败毒散治疗顽固性痤疮疗效。[方法]使用随机平行对照方法,将40例门诊患者按抽签法随机分为两组。对照组20例常规治疗。治疗组20例三豆败毒散(绿豆、黑豆各30g,炒芩、蝉蜕、野菊花各12g,天丁、地丁各10g,蒲公英15g,败酱草5g,绣防风10g,薏苡仁15g,桑白皮10g,薄荷5g,甘草10g),隔日1剂,水煎200mL,3次/d。连续治疗42d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效16例,有效3例,无效1例,总有效率95.00%。对照组显效12例,有效2例,无效6例,总有效率70.00%。治疗组疗效优于对照组(P0.05)。[结论]三豆败毒散治疗顽固性痤疮效果显著,值得推广。     

复方中药痤疮凝胶对兔耳痤疮模型治疗作用的实验研究

[目的]采用Kligman法,建立兔耳痤疮模型,观察复方中药痤疮凝胶对兔耳实验性痤疮的治疗作用。[方法]煤焦油稀释液(95%乙醇配成的2%浓度煤焦油溶液)外涂于兔耳内侧导管开口处2 cm×2 cm范围,连续14 d。肉眼及病理确认兔耳痤疮造模成功。造模成功后将兔随机分为A、B、C三组,分别于皮损处外涂5%浓度复方中药痤疮凝胶、10%浓度复方中药痤疮凝胶、维A酸乳膏治疗。治疗两周后,根据分级标准对兔耳痤疮进行分级,统计学分析复方中药痤疮凝胶对兔耳痤疮模型的治疗作用。[结果]治疗两周后,维A酸组与5%、10%浓度复方中药痤疮凝胶组与治疗前相比均取得显著效果,但三组疗效间比较无显著性差异。[结论]复方中药痤疮凝胶对实验性兔耳痤疮模型有确切治疗效果。     

Dermatologic care of sexual and gender minority/LGBTQIA youth,Part 2: Recognition and management of the unique dermatologic needs of SGM adolescents

Sexual and gender minority (SGM) individuals, including lesbian, gay, bisexual, transgender/gender diverse, questioning/queer, intersex, and asexual (LGBTQIA) persons, represent a historically underserved population within the field of medicine, though their unique health needs are increasingly recognized. Part 2 of this two‐part review will address unique concerns regarding acne, tanning behavior, sexually transmitted infections, and other health disparities among SGM adolescents. A more comprehensive understanding of the dermatologic needs of SGM youth will better allow pediatric dermatologists to actively and compassionately care for this health disparity population.     

脉冲激光引流在囊肿型痤疮患者中的应用

目的:分析脉冲激光引流在囊肿型痤疮患者中的应用效果。方法:选择笔者医院2017年3月-2018年6月皮肤科收治的176例囊肿型痤疮患者,根据随机数字表法分为对照组(n=85)和观察组(n=91),对照组采用红蓝光治疗,观察组予以脉冲激光排脓治疗,比较两组临床疗效,治疗前后皮损积分,皮肤油脂含量及角质含水量,生活质量变化情况,不良反应和随访情况。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组皮损积分、皮肤油脂含量及角质含水量,生活质量比较,差异无统计学意义(P>0.05);治疗后,两组皮损积分、皮肤油脂含量及生活质量评分均下降,观察组低于对照组,两组角质含水量均上升,观察组高于对照组,均有统计学意义(P<0.05)。两组均有一过性水肿性红斑、紫癜及面部脱屑发生,组间总不良反应发生率比较无统计学意义(P>0.05)。随访半年,两组治疗区域均无明显的瘢痕形成,对照组有2例发生轻微的凹陷性瘢痕,观察组有5例发生轻微的凹陷性瘢痕,且均未复发。结论:脉冲激光排脓治疗囊肿型痤疮疗效确切,安全性高,可促进皮损消退,后期无明显瘢痕形成。     

滚轮微针联合皮下分离术和皮肤瘢痕化学重建技术治疗痤疮凹陷性瘢痕疗效分析

目的:观察滚轮微针、皮下分离术联合皮肤瘢痕化学重建技术在痤疮凹陷性瘢痕中的应用效果。方法:选取笔者医院2018年1月-2019年1月治疗的76例痤疮凹陷性瘢痕患者,随机分为两组。对照组:36例,采用滚轮微针、皮下分离术治疗;观察组:40例,采用滚轮微针、皮下分离术联合皮肤瘢痕化学重建技术治疗,比较两组患者的临床疗效、瘢痕改善情况、不良反应以及患者的面部满意度。结果:观察组总有效率显著高于对照组(P<0.05)。治疗前,两组患者的温哥华瘢痕量表(VSS)评分无显著性差异(P>0.05);治疗后3个月两组VSS评分均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。两组并发症发生率比较无显著性差异(P>0.05)。观察组患者的面部满意度显著高于对照组(P<0.05)。结论:滚轮微针、皮下分离术联合皮肤瘢痕化学重建技术在痤疮凹陷性瘢痕中的应用效果满意,能够显著改善患者的瘢痕情况,提高临床疗效,并且安全性好,患者的面部满意度更高。     

Effectiveness of CO2 laser therapy in treating acne depressed scar: A protocol of systematic review

Background:This study is to assess the effectiveness of CO₂ laser therapy (COLT) in treating patients with acne depressed scar (ADS).Methods:Relevant randomized controlled trials will be checked by search the electronic databases of Cochrane Library, PUBEMD, EMBASE, Web of Science, Allied and Complementary Medicine Database, VIP Database, CBM database, and China National Knowledge Infrastructure. All potential randomized controlled trials of COLT for patients with ADS will be identified by 2 independent authors by searching all sources from inception to present. Two authors will independently undertake literature selection, data collection and study quality assessment. Any divergences between 2 authors will be settled down by a third author through discussion. RevMan 5.3 software will be used for statistical analysis.Results:This study will assess the effectiveness of COLT for patients with ADS.Conclusions:This study may provide helpful evidence to determine whether COLT is an effective intervention for patients with ADS.Study registration:OSF (osf.io/m9ghv).     

Inner thigh friction as a cause of acne mechanica

Acne mechanica is defined as being any acneiform eruption in areas of friction, pressure, stretching, rubbing, pinching, or occlusion of the skin in any individual, regardless of preexisting acne. Various causes have been reported, including prolonged back rest against a chair or bed, occlusive clothing, pressure from a prosthetic limb, and others. This is the first reported case of bilateral open comedones caused by inner thigh friction.