Therapeutic utility of antibacterial peptides in wound healing

Cationic antimicrobial peptides were first thought to fight infection in animal models by disintegrating bacterial peptides and later by inhibiting bacteria-specific intracellular processes. However, ever increasing evidences indicate that cationic peptides accumulate around and modulate the immune system both systemically and in cutaneous and mucosal surfaces where injuries and infections occur. Native and designer antibacterial peptides as well as cationic peptides, never considered as antibiotics, promote wound healing at every step of cutaneous tissue regeneration. This article provides an introductory list of examples of how cationic peptides are involved in immunostimulation and epithelial tissue repair, eliminating wound infections and promoting wound healing in potential therapeutic utility in sight. Although a few antimicrobial peptides reached the Phase II clinical trial stage, toxicity concerns limit the potential administration routes. Resistance induction to both microbiology actions and the integrity of the innate immune system has to be carefully monitored.     

果酸换肤治疗轻中度痤疮的护理干预

目的观察果酸换肤治疗轻中度痤疮患者的临床疗效,并探讨治疗过程中的护理干预措施.方法将2018年10月~2019年9月期间本科治疗的76例寻常痤疮患者,随机分为对照组(36)和观察组(40).对照组接受0.025%维A酸乳膏外涂,每晚一次,于临睡前点涂患处.观察组接受果酸换肤治疗配合粉刺挤压术,两周一次,两个月后比较两组患者皮损改善情况.结果观察组的总有效率为87.50%,显著高于对照组(77.78%),差异具有统计学意义(P<0.05).不良反应主要为白霜、烧灼感、刺痛,红斑以及色素沉着.结论果酸换肤可以有效治疗轻中度寻常痤疮,明显减少痤疮皮损面积,减轻炎症,配合多种护理措施干预,可提高患者依从性配合治疗,提高疗效,减少不良反应的发生率.     

Synovitis,acne, pustulosis,hyperostosis, and osteitis (SAPHO) syndrome of femoral neoplasm-like onset: a case-based review

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an umbrella term covering a constellation of bone lesions and skin manifestations, but has rarely been clarified in the clinic. We report a 28-year-old woman who had initial onset of SAPHO syndrome with involvement of the femur, and she experienced a tortuous diagnostic course. We also performed a literature review of SAPHO syndrome cases involving the femur and summarize several empirical conclusions by integrating previous findings with our case. Furthermore, we propose our perspective that ailment of the skin caused by infection of pathogens might be the first hit for triggering or perpetuating the activation of the immune system. As a result, musculoskeletal manifestations are probably the second hit by crosstalk of an autoimmune reaction. The skin manifestations preceding bone lesions can be well explained. Current interventions for SAPHO syndrome remain controversial, but drugs aiming at symptom relief could serve as the first preference for treatment. An accurate diagnosis and appropriate treatment can cure patients in a timely manner. Although the pathogenesis of SAPHO syndrome remains to be determined, physicians and surgeons still need to heighten awareness of this entity to avoid invasive procedures, such as frequent biopsies or nonessential ostectomy.     

护理干预对改善痤疮患者心理状况的研究

目的 调查住院痤疮患者的心理状况,并探讨护理干预对其心理状况的影响.方法 对86例住院重度痤疮患者采用焦虑自评量表、抑郁自评量表和症状自评量表评定其心理状况,进行一个疗程的心理干预和健康教育.结果 干预前患者的躯体化、人际关系敏感、抑郁、焦虑评分高于常模;干预后患者躯体化、人际关系敏感与常模比较,差异无统计学意义(P>...     

痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮临床研究

目的探讨痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮临床疗效及安全性,寻求有效的治疗方案。方法选择104例女性青春期后痤疮患者,随机开放分为验证组及对照组,验证组每天中午皮损处外用痤疮涂膜剂,同时每晚睡前患处涂沫0．1％阿达帕林凝胶一次;对照组仅单纯每晚外用阿达帕林凝胶患处一次。治疗8周,评定疗效,观察随访。结果验证组治愈率36．5％,有效率达96．2％;对照组治愈率15．4％,有效率82．7％。两组治愈率、有效率比较经χ^2检验P〈0．05,均有统计学差异。结论痤疮涂膜剂联合阿达帕林治疗女性青春期后痤疮疗效显著,且不良反应轻微,方法安全简便,患者易接受,值得临床推广应用。     

磺胺嘧啶银脂质水胶体对颜面部重度融合性痤疮的治疗效果观察邵利萍 黄媛媛 吴唯勤(通讯作者)

【】目的探讨磺胺嘧啶银脂质水胶体治疗重度颜面部痤疮的临床疗效,为后期临床推广应用提供参考资料。方法使用Pill Sburv及国际改良痤疮分级法进行分级,选择评级为IV级的重度痤疮共计40例,随机分为实验组与对照组,实验组磺胺嘧啶银脂质水胶体联合马齿苋,对照组使用维甲酸联合马齿苋治疗,随访患者后期疗效、炎症因素TNFα和IL-4水平及不良反应,使用SAS 9.1进行统计分析。结果实验组的治疗效果要明显优于对照组( ₂=8.076,P=0.004);实验组治疗前两组在TNF-α、IL-4差异无明显统计学意义(p>0.05),治疗后第4周、第8周结果显示实验组的TNF-α、IL-4含量要明显低于对照组,差异有统计学意义;两组不良反应发生率上,两组差异无明显统计学意义。结论目前磺胺嘧啶银脂质水胶体用于重度痤疮研究较少,联合马齿苋清理创面研究也少,本研究结果显示磺胺嘧啶银脂质水胶体联合马齿苋应用于重度颜面部痤疮治疗效果显著,可以加以推广应用。     

自血疗法对寻常型痤疮患者外周血中CD14^+单核细胞TLR2的表达及血清IL-8、TNF-α浓度的影响

目的观察自血疗法对寻常型痤疮患者外周血中CD14^+单核细胞TLR2的表达及血清IL-8、TNF-α浓度的影响,初步探讨自血疗法治疗寻常型痤疮的部分抗炎机制。方法选取30例寻常型痤疮患者为治疗组,另在本院招募健康志愿者20例作为对照组。分析治疗组采用自血疗法前、后外周血CD14^+单核细胞TLR2的表达及血清IL-8、TNF-α浓度,并与对照组比较。结果治疗组患者TLR2表达与血清IL-8、TNF-α浓度呈正相关(P<0.05)。治疗组干预前的外周血中CD14^+单核细胞TLR2表达及血清IL-8、TNF-α浓度均高于对照组及干预后(P=0.000)。结论TLR2的表达及血清IL-8、TNF-α浓度与寻常型痤疮的发病相关。自血疗法可通过下调寻常型痤疮患者外周血CD14^+单核细胞TLR2的表达,减少血清IL-8、TNF-α的分泌,从而抑制炎症反应的发生。     

420nm强脉冲光联合阿达帕林凝胶治疗中度寻常痤疮的疗效观察

目的探讨中度寻常痤疮患者联合使用420nm强脉冲光以及阿达帕林凝胶进行治疗的临床疗效。方法挑选我院收治的中度寻常痤疮患者100例进行随机分组,一组为治疗组(50例),联合使用420nm强脉冲光以及阿达帕林凝胶进行治疗,另一组为对照组(50例),单纯使用阿达帕林凝胶进行治疗。结果治疗8周后,治疗组有效率(88%)比对照组(40%)高,治疗组Ⅱ级的有效率(92.59%)比对照组Ⅱ级(56%)高,治疗组Ⅲ级的有效率(82.61%)也比对照组Ⅲ级(24%)高;差异均明显,均具有统计学意义(均P <0.05)。结论中度寻常痤疮患者联合使用420nm强脉冲光以及阿达帕林凝胶进行治疗的临床疗效显著,安全性高。     

倒膜疗法结合皮肤护理治疗面部痤疮的临床研究

目的 研究石膏倒膜疗法结合皮肤护理治疗寻常型痤疮的疗效，探讨皮肤护理在治疗中的作用。方法 将279名寻常型痤疮患者随机分为倒膜 外用药物 皮肤护理组、倒膜 外用药物组及单纯外用药物组，8周后观察疗效。结果 3组的有效率分别为87．1％，71．0％，54．8％。结论 倒膜 皮肤护理 外用药物组的疗效明显优于倒膜 外用药物组及单纯外用药物组。护士的积极参与及恰当的皮肤护理对寻常型痤疮的治愈具有重要的促进作用。     

The effectiveness of intermittent isotretinoin treatment in mild or moderate acne

BACKGROUND: Isotretinoin is the only drug that affects almost all factors in acne pathogenesis. Recently, its use for the treatment of chronic mild or moderate acne unresponsive to long-term antibiotic therapy, and with a tendency to cause scarring and leading to negative psychological effects, has became popular. The aim of the study was to investigate the effectiveness of intermittent isotretinoin treatment in mild or moderate acne. METHODS: Sixty patients with mild or moderate acne localized to the face were enrolled in the study. The treatment regimen consisted of isotretinoin, 0.5-0.75 mg/kg per day, applied for 1 week every 4 weeks for a total period of 6 months, according to the degree of acne and number of inflammatory lesions. RESULTS: Forty-one (68.3%) of the 60 patients completed the 6-month therapy. At the end of the treatment complete improvement was observed in 34 patients (82.9%) out of 41. All adverse effects were mild and discontinuation of the treatment was not necessary. CONCLUSION: Intermittent isotretinoin treatment was found to be a safe and effective choice for patients with mild or moderate acne.