Severe acne as a side effect of propranolol and nadolol in a migraineur

Beta-blockers have proven effective in the treatment of migraine. Dermatologic side effects are extremely rare. We report a patient with migraine who developed an acnelike dermatitis with two different beta-blockers with complete resolution of the acne upon discontinuation of each drug.     

3012例重型痤疮治疗现状分析

【摘要】目的 分析重型痤疮治疗现状,为提高重型痤疮疗效提供依据。方法采用抽样调查法,对首次就诊于全国35家医院皮肤科的3012例重型痤疮患者进行问卷调查,内容包括患者对痤疮的认知情况、既往干预措施及接受药物治疗情况等。结果3012例重型痤疮患者中,76.6%认为痤疮是一种疾病,但仅35.2%早期到医院就诊,其他干预措施包括自行挤压皮损、外涂药物/化妆品、钦凉茶/使用民间秘方、美容院治疗、使用遮盖性化妆品。2388例（79.3%）患者接受过口服药物治疗,包括1161例（48.6%）口服过抗生素,其中罗红霉素占33.9%,其他抗生素占 14.9%,55.5%的患者连续口服药物时间≤4周。2081例（69.1%）患者用过外用药物,其中糖皮质激素占4.3%,其他外用制剂占21.0%;外用药物常导致不良反应如红斑512例（24.6%）,脱屑683例（32.8%）,结痂73例（3.5%）,敏感性皮肤281例（13.5%）。结论重型痤疮是一种需要系统治疗的疾病,但早期就诊率较低;治疗存在药物选择缺乏靶点、外用药物不良反应明显、疗程不足的问题,应提高早期就诊率,为患者提供安全、有针对性、足够疗程的综合治疗。      

响应面法优化油腻型痤疮方中药配比

目的:通过响应面优化方法得到中医验方油腻型痤疮方的最佳复配比例。方法:采用体外抑菌实验、体外抑制透明质酸酶和凝血酶实验、抑制人体皮脂分泌实验,以这些实验结果为指标,进行响应面优化设计,最终找到最佳配比。结果:模拟预测最佳中药组方的复配比例是:蒲公英提取物1.19份,厚朴提取物2.19份,川芎提取物2.24份,在此复配比例下可得到相对抑脂率的理论值为38.9%。由于3种中药提取物都是0.2 g.mL-1,因此提取物的比例可以表示为它们中药材本身的质量比。实验实际检测值为40.25%。结论:用响应面优化法模拟预测的抑脂率与实测值非常相似,响应面优化法可较好地用于复方配伍比例的研究。     

中药内服联合异维A酸红霉素凝胶治疗寻常座疮56例

目的:观察中药内服联合异维A酸红霉素凝胶治疗寻常座疮的临床疗效。方法:100例患者随机分成2组,治疗组56例,予中药内服联合异维A酸红霉素凝胶治疗;对照组44例予中药内服。2组均15天为1个疗程,共治疗2个疗程。结果:治疗组与对照组临床疗效比较,差异有显著性(P<0.05)。结论:中药内服联合异维A酸红霉素凝胶治疗寻常痤疮疗效优于单纯内服中药。     

阿达帕林凝胶治疗寻常痤疮临床观察

目的 :观察 0 1%阿达帕林凝胶治疗寻常痤疮的临床疗效和安全性。方法 :16 0例寻常痤疮患者 ,分别给予外涂 0 1%阿达帕林凝胶 (80例 )及 0 0 2 5 %全反维A酸凝胶 (80例 )。根据治疗前后炎性损害和非炎性损害总数减少的百分率评价疗效。结果 :两组痊愈率、显效率、有效率均无统计学差异 ,阿达帕林组不良反应率明显低于全反维A酸组。结论 :0 1%阿达帕林是一种局部治疗寻常痤疮的有效的安全的药物     

Botanical and Phytochemical Therapy of Acne: A Systematic Review

Acne is prevalent among adolescents and adults with significant psychological effects. Standard oral and topical therapies can have significant side effects including skin irritation, gastrointestinal upset, and the development of drug‐resistant bacteria. The use of botanicals and phytochemicals in dermatological products is increasingly popular, and many patients are turning to these alternative therapies for treatment of acne. This study aimed to systematically review clinical studies that have investigated the use of botanical agents in the treatment of acne. PubMed and Embase databases were searched in March 2013 for trials assessing botanical therapies in the treatment of acne vulgaris. Data from these trials are presented, and methodology of each study is assessed. Twenty‐three trials met inclusion criteria. Interventions included plant extracts, herbal formulations, and phytochemicals. All studies reported favorable results, and several showed equal or superior treatment to standard therapies. No serious adverse events were reported. Few studies were methodologically rigorous. Each botanical was studied in only one or two trials. Botanicals are promising therapies for acne vulgaris although further research is warranted, especially with regard to severe acne and acne resistant to conventional therapy. There is a need for standardized methods for grading acne and assessing therapeutic effects. Copyright © 2014 John Wiley & Sons, Ltd.     

三仁汤化裁联合红蓝光对脾胃湿热证痤疮的临床疗效

目的观察三仁汤化裁联合红蓝光对脾胃湿热证痤疮的临床疗效。方法选取张掖人民医院皮肤科收治的196例脾胃湿热证痤疮患者,以密封信封法随机分为对照组和联合组,每组各98例。对照组采用红蓝光照射治疗,联合组采用三仁汤化裁联合红蓝光照射治疗,观察两组患者临床疗效、中医症状积分、血清生化指标、生活质量变化情况、不良反应和复发情况。结果治疗后联合组治疗总有效率显著高于对照组,差异有统计学意义(P0.05);治疗后两组中医症状积分(皮疹类型、皮损数量、皮疹形态和皮疹瘙痒)均显著降低,且联合组降低幅度更大,差异有统计学意义(P0.05);治疗后两组血清的P物质、胰岛素样生长因子-1(IGF-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均显著降低,且联合组降低幅度更大,差异有统计学意义(P0.05);治疗后两组痤疮患者特异性生活质量量表(Qol-Acne)中自我感知、情感功能、社会功能评分及总分均显著提高,且联合组治疗后自我感知、情感功能和总分显著高于联合组,差异有统计学意义(P0.05);治疗期间,两组不良反应发生率比较差异无统计学意义(P0.05)。随访3个月发现,联合组复发率显著低于对照组,差异有统计学意义(P0.05)。结论三仁汤化裁联合红蓝光照射治疗较单纯红蓝光照射治疗疗效更好,且有助于缓解患者皮疹症状,调节机体相关的血清因子水平,提高患者生活质量并降低复发率。     

Stearoyl-CoA desaturase inhibitors: update on patented compounds

Background: Stearoyl-CoA desaturase 1 (SCD1) has been implicated as a novel therapeutic target for the treatment of a variety of disease states, including hepatic steatosis, metabolic diseases, skin and eye disorders, and certain cancers. Objective/method: This review focuses on the novel composition of matter patents in the area of small molecule SCD1 inhibitors, along with their pharmacological effects in relevant disease models. The prospect of targeting SCD1 inhibition as a novel therapeutic approach is discussed. Conclusion: The rapid development of SCD1 inhibitors is evidenced by the increasing number of patent applications published and the number of promising preclinical compounds that have emerged in the past 5 years. Between January 2005 and February 2009, there were ～ 70 SCD1 inhibitor patent applications published.     

中药茶饮结合耳穴治疗中学生痤疮120例疗效观察

目的:观察中药茶饮和耳穴治疗中学生痤疮的临床疗效。方法:将嘉峪关市2014年高考体检痤疮学生633例,选择其中230例患者并随机分为治疗组120例和对照组110例,治疗组以中药茶饮结合耳穴治疗,对照组口服维胺酯胺囊25 mg/次,2次/d,并外用0.025%维A酸乳膏,6周后观察痤疮皮损情况。结果:中药茶饮结合耳穴治疗痤疮效果明显,总有效率达95.8%。结论:辛辣、甜腻饮食和熬夜是痤疮重要的诱发和加重因素,中药茶饮结合耳穴治疗学生痤疮优于西药对照组,而且方法简单,易为学生接受。