尿酸水平与传染性单核细胞增多症关系的研究

目的:探讨尿酸水平与传染性单核细胞增多症(IM)之间的关系.方法:本研究入组95例IM患者(男性47例、女性48例)和95名健康对照者,临床资料按性别分类.采用受试者工作特征(ROC)曲线分析法确定预测发生IM的尿酸切点值,用二元Logistic回归计算风险比(OR).结果:IM患者的尿酸水平明显低于对照组,男性尿酸水...     

刘亚娴教授小议易水学派学术研究——汇“溪”成“江”

刘亚娴教授十分强调中医学术研究要注意方法,要“善思”“脱框”(从原著的“框”架中脱出来创新),近期指导笔者以《脾胃论》为主,学习李东垣学术时又提出“开渠”,汇“溪”成“江”。本文例举李东垣所谈的“从权”、王好古所论及“派之”,《吴医汇讲》读书十则中之“读书须看反面”“读书须悟对面”“读书必须汇参”数则,例举东垣治验,并展示刘亚娴教授所谈读书要思考是什么、为什么、怎么样、怎么办,以之为学术研究之一法。     

青年直肠癌39例分析

目的 探讨青年直肠癌的临床特点及诊治.方法 对1995年1月至2005年12月收治的39例青年直肠癌进行回顾性分析.结果 青年直肠癌恶性程度高、误诊率高、晚期病例多,疗效预后差.结论 早期诊断、合理治疗可提高青年直肠癌的生存率.     

Microstructure and Mechanical Properties of Composites Obtained by Spark Plasma Sintering of Ti3SiC2-15 vol.%Cu Mixtures

Method of soft metal (Cu) strengthening of Ti₃SiC₂ was conducted to increase the hardness and improve the wear resistance of Ti₃SiC₂. Ti₃SiC₂/Cu composites containing 15 vol.% Cu were fabricated by Spark Plasma Sintering (SPS) in a vacuum. The effect of the sintering temperature on the phase composition, microstructure and mechanical properties of the composites was investigated in detail. The as-synthesized composites were thoroughly characterized by scanning electron micrography (SEM), optical micrography (OM) and X-ray diffractometry (XRD), respectively. The results indicated that the constituent of the Ti₃SiC₂/Cu composites sintered at different temperatures included Ti₃SiC₂, Cu₃Si and TiC. The formation of Cu₃Si and TiC originated from the reaction between Ti₃SiC₂ and Cu, which was induced by the presence of Cu and the de-intercalation of Si atoms Ti₃SiC₂. OM analysis showed that with the increase in the sintering temperature, the reaction between Ti₃SiC₂ and Cu was severe, leading to the Ti₃SiC₂ getting smaller and smaller. SEM measurements illustrated that the uniformity of the microstructure distribution of the composites was restricted by the agglomeration of Cu, controlling the mechanical behaviors of the composites. At 1000 °C, the distribution of Cu in the composites was relatively even; thus, the composites exhibited the highest density, relatively high hardness and compressive strength. The relationships of the temperature, the current and the axial dimension with the time during the sintering process were further discussed. Additionally, a schematic illustration was proposed to explain the related sintering characteristic of the composites sintered by SPS. The as-synthesized Ti₃SiC₂/Cu composites were expected to improve the wear resistance of polycrystalline Ti₃SiC₂.     

The Impact of COVID-19 on Academic Cancer Clinical Trials in Canada and the Initial Response from Cancer Centers

The COVID-19 pandemic resulted in temporary holds placed on new trial startups, patient recruitment and follow up visits for trials which contributed to major disruptions in cancer center trial unit operations. To assess the impact, the Canadian Cancer Clinical Trials Network (3CTN) members participated in regional meetings and a survey to understand the impact of the pandemic to academic cancer clinical trials (ACCT) activity, cancer trial unit operations and supports needed for post-pandemic recovery. Trial performance and recruitment data collected from 1 April 2020–31 March 2021 was compared to the same period in previous years. From 1 April–30 June 2020, patient recruitment decreased by 67.5% and trial site activations decreased by 81% compared to the same period in 2019. Recovery to reopening and recruitment of ACCTs began after three months, which was faster than initially projected. However, ongoing COVID-19 impacts on trial unit staffing and operations continue to contribute to delayed trial activations, lower patient recruitment and may further strain centers’ capacity for participation in academic-sponsored trials.     

Using the Penn State Worry Questionnaire to identify individuals with generalized anxiety disorder: a receiver operating characteristic analysis

We report on the use of the Penn State Worry Questionnaire (PSWQ) to identify individuals with generalized anxiety disorder (GAD). Fifty individuals with primary or secondary GAD and 114 individuals with social anxiety disorder (without GAD) completed the PSWQ. In receiver operating characteristic analyses, a score of 65 simultaneously optimized sensitivity and specificity in discriminating individuals with GAD from individuals with social anxiety disorder. Results support the use of the PSWQ in screening individuals likely to meet criteria for GAD who present for treatment at an anxiety disorders specialty clinic.