Risk stratification for mortality in cardiovascular disease survivors: A survival conditional inference tree analysis

Background and aimsEfficient analysis strategies for complex network with cardiovascular disease (CVD) risk stratification remain lacking. We sought to identify an optimized model to study CVD prognosis using survival conditional inference tree (SCTREE), a machine-learning method.Methods and resultsWe identified 5379 new onset CVD from 2006 (baseline) to May, 2017 in the Kailuan I study including 101,510 participants (the training dataset). The second cohort composing 1,287 CVD survivors was used to validate the algorithm (the Kailuan II study, n = 57,511). All variables (e.g., age, sex, family history of CVD, metabolic risk factors, renal function indexes, heart rate, atrial fibrillation, and high sensitivity C-reactive protein) were measured at baseline and biennially during the follow-up period. Up to December 2017, we documented 1,104 deaths after CVD in the Kailuan I study and 170 deaths in the Kailuan II study. Older age, hyperglycemia and proteinuria were identified by the SCTREE as main predictors of post-CVD mortality. CVD survivors in the high risk group (presence of 2–3 of these top risk factors), had higher mortality risk in the training dataset (hazard ratio (HR): 5.41; 95% confidence Interval (CI): 4.49–6.52) and in the validation dataset (HR: 6.04; 95%CI: 3.59–10.2), than those in the lowest risk group (presence of 0–1 of these factors).ConclusionOlder age, hyperglycemia and proteinuria were the main predictors of post-CVD mortality.Trial registrationChiCTR-TNRC-11001489.     

Processus,procédures et critères d’évaluation conduisant à la mise sur la liste d’aptitude aux fonctions de Maître de conférences des universités – praticien hospitalier (MCU-PH) et de professeur des universités – praticien hospitalier (PU-PH) en anesthésie-réanimation

Since several decades, anesthesia care and intensive care, as well, are engaged in the way of excellence in clinical care and research. This requirement is also applied for the selection of professor and academic workers. The goals of this article are twice: first to diffuse this knowledge at the medical community and second to describe in details the long process leading to the final appointment.     

医学检验技术专业特色建设的思考

为探讨高职高专检验专业特色建设的思路和措施。分析中原经济建设的发展对检验行业的人才需求和检验工作岗位现状,从完善教学模式、健全制度、优化师资结构、合理配置教学资源等方面提出医学检验专业特色建设相应措施。检验专业特色建设重在提高教学质量,提高系部的内涵建设,培养适应河南医疗卫生事业发展的高素质技能型检验专门人才。     

Health Status as a Mediating Factor in the Life Change-Academic Performance Relationship

Abstract

This study was designed to determine whether illness during the academic year, when gender and academic readiness are controlled, is the variable accounting for the demonstrated relationship between life change index and subsequent academic performance. A weak though significant inverse association was found between life change and grades: this association persisted even after statistical adjustment for gender, academic readiness, and illness experience. There was no evidence that illness experience mediated the life change-performance relationship. The association was not subject to a threshold effect according to level of life change.     

Looking beyond the academic and developmental logics in kindergarten education: the role of Schwab's commonplaces in classroom-based research

Kindergarten has become increasingly academic in nature. One of the primary dilemmas arising from this shift is the tension between the use of developmentally appropriate practices and the obligation to teach academic standards. To gain a deeper understanding of how kindergarten is enacted in the evolving curricular landscape, we look beyond these competing perspectives to develop a theoretical framework informed by Schwab's conception of the eclectic and the four commonplaces. We re-envision the four commonplaces – subject matter, teacher, milieu, and learner – to align them with contemporary conceptions of educational purposes, practical theory, classroom climate, and childhood. Acknowledging that kindergarten is an eclectic space, we create a robust theoretical framework for researchers interested in classroom research. The application of this framework is explored using an ethnographic methodology that integrates data from classroom observations, teacher interviews, and photo elicitation interviews with the students in one kindergarten classroom.     

2006—2019年广州市食物中毒突发公共卫生事件流行病学特征分析

目的 掌握广州市食物中毒突发公共卫生事件规律和特点,为提高其有效应对和防控提供科学依据。 方法 收集2006—2019年国家“突发公共卫生事件报告管理信息系统” 报告的广州市食物中毒突发公共卫生事件,应用描述性流行病学方法进行统计和分析。 结果 研究的14年间,广州市共报告食物中毒突发公共卫生事件89起,原因查明率为94.38%,中毒人数2 692人,死亡11人。69.66%的事件发生在5—9月。75.28%的事件致病因素是细菌,副溶血弧菌是细菌性食物中毒事件的首要致病菌,63.64%的死亡病例归因植物性食物中毒,78.65%的事件中毒场所在集体食堂。事件持续时间的中位数为13.50 h(范围为:0~135.33 h)。首例病例发生时间到接报的中位数是0.60 d(范围为:0.04~5.69 d),r=0.601,P＜0.01。 结论 加强食物中毒事件和食品安全风险监测,尽早介入处置,加强针对性的宣传,落实重点场所防控督导巡查,将有助于减少食物中毒事件发生和危害影响。