张静生辨证治疗癫痫

张静生教授认为癫痫系先天不足,后天情志失调,气机逆乱,痰浊血瘀蒙蔽神窍,神失所养,发而为病,病位在脾肝心三脏,后期涉及于肾。临床上可分为脾虚肝旺、脾肾虚损、肝肾亏虚、痰瘀蒙窍四种证型,每种证型常常相互转化,疾病后期也常互见。治疗上宜健脾涤痰,平肝潜阳,养心安神,补益肾精,活血涤痰开窍。因本病需长期治疗,张教授根据证型、病程、年龄等,辨证论治,采取个性化治疗方案,摸索出最适合组方和剂量之后,再制作成胶囊,长期服用,同时要求病人尽量避免情志刺激,保持心情舒畅。     

慢性胃炎证型及胃黏膜表现研究概况

慢性胃炎(chronic gastritis,CG)病因多为脾胃虚弱、感受外邪、情志失调,终致中焦气机不利,升降失司,不能受纳腐熟水谷。脾胃气虚是发病基础,脾胃气虚则气血生化无源,免疫力低下,易感毒及产生瘀血、食滞、痰饮等病理产物,致脏腑气机失调,经脉不通,局部组织失养而形成慢性炎症。张仲景根据"按之不痛为虚,痛者为实"原则辨其虚实,确定证治大法。辨证分型主要有脾胃虚弱、脾胃虚寒、寒邪客胃、饮食伤胃、肝郁气滞、肝气犯胃、肝胃不和、肝胃郁热、湿热中阻、瘀血停胃、胃阴亏耗等。胃镜下黏膜表现作为中医望诊延伸,是辨证分型的物质基础,各证型和胃黏膜变化之间有一定内在联系。对CG病因病机、辨证分型、辨证治疗及证型与胃镜下黏膜表现的相关性等方面概括,表明结合内镜下微观辨证对诊治CG具有明显优势,为临床处方用药提供依据。     

张子和的运气病机学说

张子和作为金元四大家之一,其学术思想"论病首重邪气",重视运气病机学说的应用。整理归纳张子和对运气病机理论的发展和认识,从病机基础、病因、病位病性、标本中气、五郁致病、运气6六个方面对张子和的运气病机进行分析,认为张氏病因以六淫立论,重视六淫之间的联系,六淫与脏腑之间的联系,六淫以"三邪"为纲。病机以脏腑为经,邪气为纬,疾病性转变以"火""湿"为主,病势变化与郁发影响有关。应用《内经》理论构建理论系统,并且依据运气病机提出"汗、吐、下"三法,使"理"明则"法"立,"法"立则"方药"出,揭示运气与疾病的内在联系。     

论温病学派对仲景湿病治法的继承与发展

湿病治法理论源于《内经》,张仲景结合临床实践,开创了湿病辨证论治的先河,为温病学派最终将湿病治法体系化奠定了基础。湿为客邪,因势利导,予以出路;湿阻于中,芳香燥化,泻之于内;湿为杂气,多兼他邪,治宜有分;湿邪发病,内外相引,治重求本。从以上四个方面探讨了温病学派对仲景湿病治法的一脉相承与创新发展。     

张仲景肺系疾病用药规律研究

目的探索张仲景肺系疾病的用药规律,以期更好地指导中医临床。方法将张仲景《伤寒杂病论》中的条文．按照肺系统所涉及的疾病依次归类,统计肺系用药的功效、四气、五味、归经和前15味药物。结果功效用药依次为补虚药、解表药、化痰止咳平喘药、温里药、清热药、泻下药、利水渗湿药、活血化瘀药、收涩药等;四气用药依次为温、寒、平、热、凉;五味用药依次为甘、辛、苦、酸、咸;归经用药依次为：肺经、脾经、心经、肝经、胃经、肾经等;前15味药物依次为甘草、大枣、干姜、生姜、桂枝、半夏、人参、五味子、芍药、茯苓、麻黄、细辛、桔梗、石膏、杏仁、附子、蜂蜜。结论张仲景用药灵活严谨,就肺系用药规律概括为“表里同治,上下兼医,调节宣肃,匡正治节,注重肺胃,权衡攻补。辛温化饮,苦寒泄肺,治从五脏,兼顾肠腑”。     

Epidermal Neural Crest Stem Cells (EPI-NCSC) and Pluripotency

This article serves three purposes. We summarize current knowledge of the origin and characteristics of EPI-NCSC, review their application in a mouse model of spinal cord injury, and we present new data that highlight aspects of pluripotency of EPI-NCSC. EPI-NCSC are multipotent stem cells, which are derived from the embryonic neural crest and are located in the bulge of hair follicles. EPI-NCSC can undergo self-renewal and they are able to generate all major neural crest derivatives, including neurons, nerve supporting cells, smooth muscle cells, bone/cartilage cells and melanocytes. Despite their ectodermal origin, neural crest cells can also generate cell types that typically are derived from mesoderm. We were therefore interested in exploring aspects of EPI-NCSC pluripotency. We here show that EPI-NCSC can fuse with adult skeletal muscle fibers and that incorporated EPI-NCSC nuclei are functional. Furthermore, we show that adult skeletal muscle represents an environment conducive to long-term survival of neurogenic EPI-NCSC. Genes used to create induced pluripotent stem (iPS) cells are present in our EPI-NCSC longSAGE gene expression library. Here we have corroborated this notion by real-time PCR. Our results show similarities in the expression of Myc, Klf4, Sox2 and Lin28 genes between EPI-NCSC and embryonic stem cells (ESC). In contrast there were major differences in Nanog and Pou5f1 (Oct-4) expression levels between EPI-NCSC and ESC, possibly explaining why EPI-NCSC are not tumorigenic. Overall, as embryonic remnants in an adult location EPI-NCSC show several attractive characteristics for future cell replacement therapy and/or biomedical engineering: Due to their ability to migrate, EPI-NCSC can be isolated as a highly pure population of multipotent stem cells by minimally-invasive procedures. The cells can be expanded in vitro into millions of stem cells/progenitors and they share some characteristics with pluripotent stem cells without being tumorigenic. Since the patients’ own EPI-NCSC could be used for autologous transplantation, this would avoid graft rejection.     

张士舜中医肿瘤转移辨治思路

张士舜老师根据40年治疗癌症的经验,提出辨证论治、辨病理论治、辨病位论治"三辨治癌"的治疗模式。文章从辨证论治与辨病论治中医思想,组方整体性与原则性、灵活性特点,分析还原与系统综合方法相结合复方研究理念,传统观念与现代研究成果相结合模式,对中医肿瘤转移辨治思路启示等几方面谈对"三辨治癌"的理解。分析"三辨治癌"思维模式对中医肿瘤研究的思路和方向,研究成果的性质和水平,以及对于理论的形成和发展的先导作用和临床价值。     

《伤寒杂病论》与《辅行诀》《汤液经》《内经》关系探究

首先从《甲乙经》序《、汉书.艺文志》著录以及仲景自序《、古本康平伤寒论》等史料推求《伤寒论》渊源;其次旁引敦煌遗书《辅行诀五脏用药法要》文字与方药,证明其与仲景书有亲缘关系,皆源于古《伊尹汤液经》;又通过分析《伤寒》与《内经》的内容,结合伤寒原序,认为"仲景写成《伤寒论》不过数年之功",没有"成熟的方书"作为参照是不可能的,说明《伤寒》的确源于《汤液经》等古经方,而并非依据《内经》理论自造。     

张良英教授分期论治滑胎的经验总结

介绍张良英教授分期论治滑胎经验。张良英教授分两期治疗本病：未孕前以预防为主,采用补肾益气,养血调经,调补冲任,给予自拟助孕Ⅰ号方、助孕Ⅱ号方或扶正固本方。孕后以固冲安胎,对症治疗。胎元未殒,安胎止血为主,用自拟保胎饮;胎元已殒者,以下胎益母为主,采用刮宫术去胎、引产术去胎,中药以生化汤为主加减应用。     

张聿青运用炙甘草汤之经验

通过对清代张聿青运用炙甘草汤的配伍规律研究,分析其灵活化裁仲景方的理论依据与具体用药经验,以期对现代临床运用炙甘草汤有实际的指导意义。