带蒂组织瓣在颌面部软组织缺损中的应用

目的：探讨颌面部软组织缺损的修复方法。方法：根据38例病人颌面部软组织缺损面积的大小采用不同类型的带蒂组织瓣修复。结果：38例病人术后组织瓣转移修复均存活，术后病人颌面部软组织功能及外形得到明显改善．结论：颌面部软组织缺损的整复和术式的选择应依据缺损的情况、各种皮瓣的特点和术者的技能经验，精心设计，采用不同类型的皮瓣修复缺损，可获得较为满意的效果。     

Intrauterine fertilization capsules—A clinical trial

Treatment of 26 women with tubal infertility was attempted using intrauterine capsules loaded with oocytes and spermatozoa. The stimulation protocol was as used for in vitro fertilization and embryo transfer and consisted of short-term use of Buserelin, human menopausal gonadotropin, and human chorionic gonadotropin. Oocytes were collected by ultrasonically guided transvaginal aspiration, and spermatozoa were prepared by swim-up technique. The gametes were placed in agar capsules 4 hr after oocyte collection, and the capsules were introduced to the uterine fundus using an insertion tube and piston from an intrauterine device. Six complete capsules and parts of two other capsules were expelled. None of the women became pregnant, compared with a pregnancy rate of 21% per aspiration following in vitro fertilization and embryo transfer during the same period.     

Use of the subrenal capsule assay to measure antibody-dependent,cell-mediated cytotoxicity against head and neck tumors

Summary Experience with antibody-dependent, cellmediated cytotoxicity (ADCC) has shown that antibody can increase the localization and killing capacity of lymphocytes. We tested the possibility of improving the activity of lymphokine-activated killer cells (LAK) on human tumor using the subrenal capsule assay in nude mice. The tumors were first grown in the renal capsule space and the effector cells injected later. In the model experiment we used M21 melanoma and monoclonal antibody against melanoma-associated antigen GD3. This antibody increases the tumor inhibitory activity of LAK cells from healthy donors in comparison to LAK alone. We have been able to prove the clinical relevance of such an approach. Tumor bioptic material from five tumor patients was tested with various monoclonal antibodies, following which the highly reactive antibodies were selected and incubated with the patient's LAK cells. Such pretreated LAK cells have a high growth-inhibitory effect on autologous tumor growing in the renal capsule space of the test mice.     

腺泡状软组织肉瘤临床病理及其组织发生的研究

报告３１例腺泡状软组织肉瘤。此瘤最常发生于年轻人下肢，５年生存率为５４．５％。２８例作免疫组化，２３例肌红蛋白阳性（８２．１％），１８例结蛋白阳性（６４．３％），３例Ｓ－１００蛋白阳性（１０．７％）；而神经原特异性烯醇化酶、神经微丝、溶菌酶、α１－抗胰蛋白酶、第Ⅷ因子相关抗原、角蛋白、上皮膜抗原、波形蛋白均为阴性．２例作电镜观察，瘤细胞浆内可见特殊的菱形结晶。作者认为腺泡状软组织肉瘤与肌细胞性肿瘤的常见类型之间可能存在着内在联系。     

Prognostic factors in head and neck soft tissue sarcomas: Analysis of 128 cases

Soft tissue sarcomas make up a heterogenous group of rate malignant tumors originating from mesodermal tissues. Although there have been several improvements in diagnostic methods, staging, and treatment over the past few years, the prognosis of head and neck sarcomas remains worse than those sited at the trunk or extremities. The purpose of this retrospective study was to report the survival results of 128 consecutive patients with soft tissue sarcomas of the head and neck treated from 1953 to 1985. Of the 93 patients submitted to surgical resection, the procedure was considered radical in 67 patients. Of the operated gruop, 46 patients (49.5%) developed recurrence of disease. Thirty-two patients underwent further treatment (surgery, radiotherapy, or chemotherapy), and 14 patients were salvaged, giving the ultimate result of 65.6% disease control rate in the operated group. The univariate survival analysis showed no statistical difference (P > 0.05) according to age, race, sex, and site or histologic type of the tumor. Radicality of surgery was an important prognostic factor affecting survival (P = 0.0014 for disease-free interval and P = 0.0183 for overall survival). The multivariate analysis showed that the radicality of surgery and tumor histology were independent prognostic factors affecting recurrence. The same variables and age group were related to the risk of death. Every effort must be made to make an early diagnosis and a radical surgical resection of these tumors must be tried (except for embryonal rhabdomyosarcoma), because it offers the best chance for cure. © 1994 Wiley-Liss, Inc.     

Drift barriers in the postcartilaginous development of the mammalian otic capsule

Summary Postcartilaginous development of the otic capsule was studied in undecalcified histological material from rabbits following sequential fluorochromic time labeling of mineralizing tissues, using combined microradiography, fluorescence microscopy and osteoid staining. Early fetal bone formation was monitored by labeling of the experimental animals in utero. In contrast to the normal pattern of drift movements displayed by long bones and extracapsular cranial bone, capsular bone inside a zone immediately surrounding the perilymphatic space developed as a separate functional unit in which growth and modeling was absent. Bone tissue behavior appeared to depend on its spatial relation to the membranous labyrinth rather than histological characteristics. These findings suggest the role of inner ear tissues as a functional matrix in control of capsular bone dynamics beyond fetal life.     

平消胶囊与抗癌药物联用治疗晚期肺癌40例报告

本文采用抗癌中成药平消胶囊与抗癌药物司漠司汀（Me－CCNU），5-氟脲嘧啶多相脂质体（139－3）联用，治疗晚期肺癌40树．疗效CR＋PR30％（12／40），优于对照组20％（4／20）．与国内外文献报道相比疗效相似．本文结果表明，平消胶囊改善临床症状，延长生存期。副反应轻（包括骨髓抑制），经两组对照，（P＜0．05或＜0．01）．对肺癌疗效更佳，服药后，食欲增加，精神好转，疼痛减轻，能提高患者的生活质量．     

红景天胶囊对心肌缺氧、缺血保护作用的实验研究

本研究观察到，灌胃给红景天胶囊可使小鼠夹闭气管后心电消失时间，常压和低压缺氧条件下平均存活时间延长，使大鼠注射垂体后叶素所致心肌缺血阳性反应数减少；大，中两剂量组与生理盐水对照组比较，各项指标均有显著性差异，其作用强度亦优于复方丹参片对照组。     

愈心痛胶囊对急性心肌缺血犬血浆内皮素和血清一氧化氮的影响

本研究观察了中药复方愈心痛胶囊消化道给药对实验性急性心肌缺血犬血浆内皮素（ＥＴ）和血清一氧化氮（ＮＯ）水平及肌酸磷酸激酶（ＣＰＫ）活性的影响。结果显示：在犬急性心肌缺血过程中血清ＣＰＫ活性和血浆ＥＴ水平均显著增高，血清ＮＯ水平下降。愈心痛胶囊两个剂量组均可明显抑制实验性犬心肌损伤时ＣＰＫ的溢出和血浆ＥＴ的过量释放，同时促进ＮＯ的生成和释放，与盐水对照组比较差异显著（Ｐ＜０．０５～０．００１），从而保护心肌免受缺血性损伤，其作用效果与剂量呈正相关。