黄体酮胶囊在早期先兆流产中的临床应用效果

目的 了解黄体酮胶囊在早期先兆流产中的临床应用效果.方法 随机选取19例早期先兆流产患者作研究组,给予黄体酮胶囊治疗;另选取19例早期先兆流产患者作对照组,给予肌肉注射黄体酮针治疗,对比两组患者采用不同疗法后的治疗效果.结果 研究组患者口服黄体酮胶囊治疗后的保胎成功率为94.73％,对照组患者肌注黄体酮针治疗保胎成功率为68.42％,结果比较差异有统计学意义(P＜0.05).结论 黄体酮胶囊治疗早期先兆流产可避免因针剂注射为患者带来的痛苦,效果值得肯定.     

肾保康胶囊的质量标准

目的:建立肾保康胶囊的质量控制方法.方法:用薄层色谱法对肾保康胶囊中的金银花、发酵虫草菌粉进行定性鉴别;采用高效液相色谱法测定盐酸小檗碱的含量.结果:薄层色谱中斑点清晰,易于识别;盐酸小檗碱线性范围为0.0351～0.263μg,r=0.9999,平均回收率为96.30%,RSD为1.45%.结论:本方法简便,灵敏度高,可有效地控制肾保康胶囊的质量.     

丽珠肠乐联合曲美布汀治疗肠易激综合征临床疗效观察

目的探讨丽珠肠乐联合曲美布汀治疗肠易激综合征的临床疗效及不良反应。方法将116例临床诊断的肠易激综合症患者随机分成丽珠肠乐联合曲美布汀组（A组,n=40）、丽珠肠乐组（B组,n=38）和曲美布汀组（C组,n=38）,A组给予丽珠肠乐口服1次2粒,早晚各1次餐后口服,曲美布汀口服每次0．1g,每133次;B组和C组则单独口服以上二药治疗,4周为一疗程。三组分别于治疗前、治疗4周后观察临床症状及不良反应。结果治疗4周后,A、B、C三组临床总有效率分别为92．5％,71．1％和78．9％,三组比较差异有显著性（P〈0．05）,三组均未见明显不良反应。结论丽珠肠乐联合曲美布汀治疗肠易激综合征比单用丽珠肠乐或曲美布汀具有更好的疗效。     

芪骨胶囊治疗绝经后骨质疏松症的分子机制

目的 运用网络药理学的方法探究芪骨胶囊治疗绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的活性成分与潜在分子机制.方法 从BATMAN-TCM数据库中获取芪骨胶囊的主要活性成分及其对应的靶点,在GeneCards数据库和GEO数据库中筛选PMOP疾病靶点,将药物靶点与疾病靶点取交集...     

紫外分光光度法测定复方松果体素胶囊中松果体素的含量

目的:建立以紫外分光光度法测定复方松果体素胶囊中松果体素含量的方法。方法:采用紫外分光光度法,检测波长为277nm。结果:松果体素检测浓度在5～25μg/ml范围内与吸收度线性关系良好(r=0.9996);平均加样回收率为96.49%(RSD=1.21%,n=6)。结论:本方法准确、可靠,操作简便,稳定性好。     

柳胺酚胶囊溶出度的测定

建立柳胺酚胶囊溶出度的试验方法。以 2 5 %乙醇溶液为溶出介质 ,采用“转篮法”,转速为 10 0 r/ m in,温度为37± 0 .5°C。紫外分光光度法测定 ,检测波长为 2 93nm,4 5 min时柳胺酚溶出度大于 70 %。     

Cell membrane capsule: a novel natural tool for antitumour drug delivery

Introduction: Chemotherapy plays an important role in antitumour therapy, but causes serious adverse reactions. So, drug delivery system (DDS) with cell-targeting ability is an important method to reduce adverse reactions while ensuring the effectiveness of chemotherapy. Synthetic drug carriers and DDSs based on cells have proven safety and efficacy, but they also have many deficiencies or limitations. Cell membrane capsules (CMCs), which are based on extracellular vesicles (EVs), are a promising biomimetic DDS that retains some cell membrane channels and cytoplasmic functions, with escape macrophage phagocytosis.

Areas covered: The EVs for constructing CMCs can be prepared by natural secretion, chemical-induced budding, nanofilter membrane extrusion and similar methods and are isolated and purified by a variety of methods such as centrifugation and liquid chromatography. CMCs can target the tumour cells either spontaneously or through targeting modifications using proteins or aptamers to actively target the tumour cells. CMCs can be directly wrapped with chemicals, photosensitizers, RNA, proteins and other ingredients, or they can be loaded with antitumour agent-loaded synthetic nanoparticles, which are delivered to the target cells to play a specific role.

Expert opinion: This review describes the concept, function, characteristics, origins, and manufacturing methods of CMCs and their application in antitumour therapy.     

皮敏消胶囊联合丹皮酚软膏治疗皮肤瘙痒症疗效观察

目的观察皮敏消胶囊联合丹皮酚软膏治疗皮肤瘙痒症的疗效及安全性。方法治疗组68例口服皮敏消胶囊4粒,3次/d,赛庚啶片4 mg/晚;对照组66例仅口服赛庚啶片,用法用量同治疗组。局部用药:治疗组外用丹皮酚软膏,3次/d;对照组外用氟芬那酸丁酯软膏,3次/d。两组病例均连续治疗观察4周判定疗效,记录症状改善情况。结果治疗组有效例数50例,有效率73.53%;对照组34例,有效率51.52%。两组比较,χ2=6.94,P0.01。治疗组随访61例,复发或加重13例(21.31%);对照组随访57例,复发或加重26例(45.61%)。两组比较,χ2=7.87,P0.01。结论皮敏消胶囊联合丹皮酚软膏治疗皮肤瘙痒症疗效肯定,安全性好。     

双唑泰栓联合转移因子治疗复发性外阴阴道假丝酵母菌病

目的：探讨双唑泰栓联合转移因子治疗复发性外阴阴道假丝酵母菌病（RVVC）的疗效及安全性。方法将240例RVVC患者按随机数字表法分为治疗组（予双唑泰栓＋转移因子胶囊治疗）和对照组（予双唑泰栓治疗），7 d为一疗程，共两疗程，随访3个月。观察2组的临床疗效、不良反应及复发率。结果治疗组总有效率为92.7%，明显高于对照组的81.0%（P〈0.05）。治疗组Sobel 评分、复发率均低于对照组（P〈0.01）。2组不良反应轻微且差异无统计学意义（P〉0.05）。结论双唑泰栓联合转移因子治疗RVVC安全有效，能明显降低复发率。     

Hazard of household cleaning products: A study undertaken by the UK National Poisons Information Service

Objective. To ascertain the reported toxicity of current United Kingdom (UK) household products following the launch of new products, such as liquid detergent capsules, and the manufacture of more concentrated formulations. Methods. Between 1 March 2008 and 30 April 2009 the UK National Poisons Information Service (NPIS) collected prospectively 5939 telephone enquiries relating to household products, approximately 10% of all telephone enquiries received over this period. Results. The majority of enquiries (n =?3893; 65.5%) concerned children 5 years of age or less and were received predominantly from hospitals (n =?1905; 32.1%), general practitioners (n =?1768; 29.8%) and NHS Direct/NHS 24 (n =?1694; 28.5%). The majority of exposures occurred at home (n =?5795; 97.6%); most exposures were accidental (n =?5561; 93.6%). Liquid detergent capsules were most commonly involved (n =?647), followed by bleaches (n =?481), air fresheners (n =?429), multipurpose cleaners (n =?408), dishwasher products (n =?399) and descalers (n =?397). Exposure to household products occurred mainly as a result of ingestion (n =?4616; 75.8%), with eye contact (n =?513; 8.4%), inhalation (n =?420; 6.9%) and skin contact (n =?187; 3.1%) being less common; 5.1% (n =?313) of enquiries involved multiple routes of exposure. The most commonly reported features were vomiting (ingestion), pain (eye contact), dyspnoea (inhalation) and burns (skin contact). In 5840 of 5939 enquiries the Poisoning Severity Score (PSS) was known. The majority of patients (n =?4117; 70.5%) were asymptomatic (PSS 0), 28.0% (n =?1638) developed minor features (PSS 1), 1.3% (75 patients) developed moderate features (PSS 2) and 0.15% (nine patients) developed serious features (PSS 3). Four of these nine patients made a complete recovery, two died from exposure to drain cleaner and PVC solvent cleaner; the outcome in three was unknown. Conclusion. In the UK, advice from the NPIS is sought commonly regarding household products, but such exposures only rarely result in clinically serious features. As 65.5% of exposures were in children less than 5 years of age, parents clearly have an important role to play in ensuring that household products are stored safely at all times.