Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature

Waldenstr?m's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenstr?m's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing-Neel syndrome) has rarely been reported. We describe the case of a 72-year-old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed.     

稳心颗粒用于有症状良性室性早搏的疗效观察

目的：评价中药稳心颗粒对有症状良性室性早搏的治疗效果。方法：选择普通健康者和未查出心脏原发、继发病变。却自觉有室性早搏相关症状(心悸、气短、胸闷、头晕，甚至心神不宁)者且非住院病人74例随机分为对照组(40例)和治疗组(34例)，对照组给予调整植物神经药物谷维素，个别加用镇静药安定；治疗组服用稳心颗粒．分别测定治疗前及治疗4周后动态心电图和观察病人的临床症状。结果：对照组及治疗组显效率分别为15．0％、44．1％，总有效率分别为50．0％、73．5％。结论：室性早搏多为气阴两虚、气滞血瘀引起，稳心颗粒对良性室性早搏的疗效确切。     

王冰生平之谜

王冰对中医学建树良多，了解其生平可有助于分析其撰著内涵。但遍寻王冰史料，对其生平争论甚多，有些至今没有定论。本文从王冰的名、号、师承、生卒年月、官职等阐明王冰扑朔迷离的生平，指出要进一步解开王冰的生平之谜，尚有赖于更多的史料发掘。     

调免素的临床研究

本文报告调免素治疗消化系统及内科其它系统疾病319例的临床疗效与机体免疫功能变化,与对照组60例,分析、探讨了调免素的临床应用价值。两组病人治疗后总有效率分别为84.0％和63.68％(P<0.05)。调免素治疗组细胞免疫功能有明显改变(P<0.01),对照组不明显。调免素在临床上使用是安全的。     

论《内外伤辨惑论》辨虚实本质及内外伤的相关性

[目的]探讨金元医家李东垣的奠基之作《内外伤辨惑论》的辨惑本质以及内伤与外感病的相关性。[方法]通过对《内外伤辨惑论》立论背景的研究,分析该论中主要的十三辨,进而思考辨惑的本质;同时联系李氏代表著作《脾胃论》中对解表药（风药）升发阳气作用机理的阐发,并与张仲景《伤寒论》等学术思想相比较,讨论外感风寒与内伤脾胃的对立与转化关系。[结果]发现《内外伤辨惑论》的辨惑实质并非在于病位之表里,而在于病证之虚实;从风药的作用机理以及表证、风药与脾胃的关系等分析,提出了内伤与外感病存在相关性。[结论]对《内外伤辨惑论》辨虚实本质的揭示及对解表药作用本质、内伤和外感相关性的认识,可以为临床辨证用药打开一些思路。     

运气学说沿革及评价

运气学说是中医理论的重要组成部分,其内容集中反映于《素问》的“七篇大论”,是王冰发现并加以注释及传承的第一人．自此以后,经两宋金元及明清以降,运气学说几经周折起落,时至今日,人们当以科学严谨的理性态度对待运气学说。     

浅析大黄在《伤寒杂病论》中的应用及其现代药理机制

大黄具有泻下通便、活血消瘀、祛湿热退黄疸、泻热逐水、攻下宿食、清泻胃热、泻热凉血、清热解毒等作用,张仲景以《神农本草经》所载大黄功效为根据,结合个人体会,充分发挥了大黄的多种功能和不同作用,将其广泛用于阳明腑实证、瘀血证、黄疸等众多疾病的治疗中。而现代研究亦进一步证实、发展了大黄的效用,使之更有效地服务于临床。     

薤白的本草考证

通过本草考证与实地考察,认为古代所用的薤白是百合科植物薤Allium chinense,而不是小根蒜A.macrostemon,把小根蒜作薤白使用发生在清代以后,建议把薤与小根蒜并作中药薤白的植物来源。     

Lactate dehydrogenase and isoenzyme changes in rats with experimental thiamine deficiency.

Heat and liver lactate dehydrogenase (LDH) and isoenzyme distributions were studied in rats with experimental thiamine deficiency. No change in total heart LDH activity was observed on days 24 and 40 of a thiamine deficient diet. At the time of symptoms (average 53 days on diet), total heart muscle LDH was slightly decreased in thiamine deficient rats (248 +/- 12 U/g tissue, Mn +/- SE) compared to ad lib fed controls (293 +/- 12, p less than 0.05), but did not differ from pair fed controls (273 +/- 15). Heart muscle LDH isoenzyme distribution showed a relative increase in the H4 band and a decrease in the H2M2 and HM3 bands in thiamine deficiency on day 24. This pattern became more promient by day 40. Calculated total M-LDH activity of heart muscle in thiamine deficient rats was significantly decreased at day 40 (44 +/- 3) compared to pair fed controls (57 +/- 5, p less than 0.05) and ad lib fed controls (85 +/- 7 p less than 0.001). Further changes were not observed in the symptomatic stage. Total H-LDH in heart muscle did not change during the period of study, while total liver LDH activity was reduced in thiamine deficient rats at the symptomatic stage (137 +/- 15) compared with pair fed controls (193 +/- 12, p less than 0.05) and ad lib fed controls (407 +/- 50, p less than 0.01). Liver isoenzyme electrophoresis showed an almost 100% distribution to the M4 band. The present investigation demonstrates a decrease in cardiac muscle M-LDH in experimental thiamine deficiency. Differences in LDH isoenzyme distribution in chronic hypoxia and thiamine deficiency are discussed.