Lignans from Dendrobium chrysanthum

A new neolignan glucoside denchyside B along with three known lignans have been isolated from the herbs of Dendrobium chrysanthum Wall. (Orchidaceae). The structures were elucidated on the basis of spectroscopic methods.     

Scyphiphin D,a new iridoid glucoside dimer from Scyphiphora hydrophyllacea

From the aerial parts of Scyphiphora hydrophyllacea Gaertn. F., a new iridoid glucoside dimer scyphiphin D (1) and a known iridoid glucoside geniposidic acid (2) were isolated. The structure of this new compound was determined on the basis of HR-FAB-MS, IR, ¹H and ¹³C NMR (DEPT), and 2D NMR (HMQC, HMBC, COSY, ROESY) spectral data.     

Water-soluble constituents from the leaves of Ilex oblonga

Four new water-soluble constituents, oblongaroside A (1), oblongar ester A (2), oblongaroside B (3), and oblongaroside C (4), were isolated along with four known compounds: 4-O-β-d-glucopyranosyl-3-hydroxybenzalcohol (5), 7-methoxyl-4-O-β-d-glucopyranosyl-3-hydroxybenzalcohol (6), 4-O-β-d-glucopyranosyl-3-hydroxybenzoic acid (7), and 3,4-dihydroxybenzoic acid (8) from the leaves of Ilex oblonga. Identification of their structures was achieved by 1D and 2D NMR experiments, including ¹H–¹H COSY, NOESY, HMQC, and HMBC methods and FAB mass spectral data.     

复方甘草酸苷联合丹皮酚软膏治疗48例变应性接触性皮炎临床观察

目的:探讨复方甘草酸苷联合丹皮酚软膏治疗变应性接触性皮炎(ACD)的临床。方法:96例ACD患者被随机分为对照组和治疗组,每组各为48例。对照组口服复方甘草酸苷片3次/d,2片/次。治疗组在对照组基础上外用丹皮酚软膏,2次/d。治疗后观察和比较两组临床疗效、症状积分和免疫因子水平变化及不良反应情况。结果:治疗组治疗后痊愈率和总有效率分别达到66.67%和85.42%,显著高于对照组痊愈率和总有效率(P0.05);治疗组治疗1、2和3周后症状积分分别为(5.23±1.1)分、(3.07±1.08)分和(1.32±0.82)分,均显著低于治疗前和对照组治疗后水平(P0.05);治疗后sIL-2R为(2.11±0.76)ng/mL,显著低于对照组(P0.05),而IL-2和IFN-γ水平为(28.14±2.37)pg/mL和(28.04±11.06)pg/mL,显著高于对照组(P0.05);两组不良反应率无统计学意义(P0.05)。结论:口服复方甘草酸苷联合外用丹皮酚软膏,能显著改善ACD患者症状评分,降低炎性因子水平,不良反应少,疗效显著优于单用复方甘草酸苷。     

归丹沙棘胶囊的快速薄层鉴别与二苯乙烯苷和丹酚酸B同时测定

目的 为多指标快速控制保健食品质量,对归丹沙棘胶囊质量控制方法进行研究。方法 在2块薄层板上鉴别何首乌、丹参、沙棘、当归和苦杏仁。采用反相高效液相色谱,以甲醇-乙腈-甲酸-水(24∶9∶1∶66)为流动相,300 nm为检测波长,同时测定样品中二苯乙烯苷与丹酚酸B的含量。结果 通过方法学考察,二苯乙烯苷的进样量在0.042 3~0.846 μg (r=0.999 5)、丹酚酸B的进样量在0.118~2.36 μg(r=0.999 6)与峰面积呈良好的线性关系。二苯乙烯苷的平均回收率为99.04%,丹酚酸B的平均回收率为98.47%;其RSD(n=9)分别为0.66%和 0.83%。TLC鉴别阴性无干扰。结论 本方法简便、快捷、实用,能够整体控制归丹沙棘胶囊的质量。     

唐古特大黄化学成分研究

目的 研究蓼科大黄属植物唐古特大黄Rheum tanguticum根的化学成分。方法 采用硅胶和凝胶柱色谱方法进行分离,经核磁和质谱等波谱分析方法鉴定化合物结构。结果 分离得到16个化合物,分别鉴定为大黄酚（1）、大黄素（2）、大黄素甲醚（3）、大黄酚-1-O-β-D-葡萄糖苷（4）、大黄酸（5）、芦荟大黄素8-O-β-D-吡喃葡萄糖苷（6）、大黄素8-O-β-D-吡喃葡萄糖苷（7）、林氏莲花掌素（8）、4-(4′-对羟基苯基)-2-丁酮-4′-O-β-D-葡萄糖苷（9）、白黎芦醇4′-O-β-D-吡喃葡萄糖苷（10）、白黎芦醇4′-O-β-D-(6″-O-没食子酰)-吡喃葡萄糖苷（11）、6-羟基酸模素-8-O-β-D-吡喃葡萄糖苷（12）、表儿茶素-3-O-没食子酸酯（13）、儿茶素（14）、对羟基苯丙烯酸葡萄糖酯（15）、对羟基苯甲酸葡萄糖酯（16）。结论 化合物15、16为首次从唐古特大黄中分离得到。     

应用β-七叶皂甙钠辅助治疗慢性肺心病急性加重期的临床疗效观察

目的探讨β-七叶皂甙钠辅助治疗慢性肺心病急性加重期的临床疗效。方法选取我院心内科120例慢性肺源性心脏病合并心力衰竭急性加重期患者,随机分为治疗组和对照组,对照组患者采取常规治疗,治疗组患者在常规治疗的基础上加用β-七叶皂甙钠20mg,静脉点滴,每天1次加入等渗葡萄糖液250mL。结果在经过治疗后,治疗组患者的右室舒张末内径减小（P〈0.05）,右室射血分数增加（P〈0.05）,与对照组患者相比差异有统计学意义。治疗组患者呼吸情况、心功能改善明显优于对照组患者,2组患者疗效比较差异有统计学意义（P〈0.05）。结论慢性肺源性心脏病合并心力衰竭患者在常规治疗的基础上加用β-七叶皂甙钠能够更好的改善心衰患者的心脏功能,缓解患者的临床症状,疗效满意,在临床上值得推广。     

抗HBV核苷类似物的利用趋势分析

目的了解近年来抗HBV（乙型肝炎病毒）核苷类似物的利用趋势,为临床合理用药提供参考。方法根据医院网络系统,采用限定日剂量（DDD）、用药数量、金额及用药频度（DDDs）等指标,对四川省人民医院2008～2010年抗HBV核苷类似物的使用情况进行统计分析。结果抗HBV核苷类似物的使用数量和金额呈逐年上升趋势,其中阿德福韦酯和恩替卡韦的用量增幅较大,拉米夫定用量上升趋势变缓。结论抗HBV核苷类似物临床使用基本合理,拉米夫定和阿德福韦酯占主导地位,恩替卡韦有很好的应用前景。     

Nine new compounds from the whole plants of Rehmannia henryi

Eight new iridoids (1–8) and an ionone glucoside (9), together with 31 known compounds (10–40), were isolated from the whole plants of Rehmannia henryi. The structures of these compounds were elucidated on the basis of their spectroscopic data and chemical evidence.     

Two new lignan glucosides from the fruit of <Emphasis Type="Italic">Vitex cannabifolia</Emphasis>

Two new phenyldihydronaphthalene-type lignan glucosides, vitecannasides A (1) and B (2) were isolated from the fruit of Vitex cannabifolia Sieb. et. Zucc. (Verbenaceae) along with the six known lignan derivatives (3–8), four known iridoid glucosides (9–12), three known flavonoids (13–15), and one known phenylbutanone glucoside (16). Their chemical structures were determined on the basis of spectroscopic data as well as chemical evidence. The scavenging effect of 1, 2, and 11–16 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was examined. Compounds 1, 2, 14, and 15 exhibited stronger activity than that of l-cysteine. Especially, 14 and 15 showed more potent activity than that of α-tocopherol.