旋覆代赭汤对反流性食管炎大鼠血清FT4、TSH的影响

目的:观察旋覆代赭汤对反流性食管炎的疗效并探讨其作用机制方法:采用"食管-十二指肠端侧吻合术",造成大鼠反流性食管炎动物模型。64只大鼠随机分为4组,予以不同治疗后,观察大鼠食管黏膜病理变化及血清游离甲状腺激素(free thyroxine,FT4)、促甲状腺激素(thyrotropic hormone,TSH)浓度。结果:①中药组、西药组体质量增加值分别与模型组比较显著增加(P<0.05)。②中药组、西药组病理形态学光镜检查积分与模型组比较有显著性差异(P<0.05)。③中药组、西药组血清浓度与模型组比较显著升高(P<0.05)。结论:旋覆代赭汤能改善模型大鼠松弛的食管下括约肌,其作用机制可能是提高血清FT4、TSH浓度,促进大鼠食管肌条的收缩幅度、收缩频率,增强消化道蠕动功能。     

黄连与吴茱萸的不同配伍比例对热证大鼠IL-6,IL-8和TSH的影响

目的 :观察黄连与吴茱萸不同比例配伍对热证大鼠IL_6 ,IL_8 ,TSH的影响。方法 :用党参与黄芪给大鼠灌胃造成热证模型 ,分别用黄连与吴茱萸比例为6∶1(左金丸) ,2∶1(甘露散)和1∶1(茱萸丸)的煎剂治疗。结果 :6∶1(左金丸)和2∶1(甘露散)的配伍比例能使热证大鼠血清IL_6和TSH降低(P<0 05) ,1∶1(茱萸丸 )使它们改变不明显。结论 :左金丸和甘露散有消除热证病理改变的作用 ,与原方分别用于治疗肝热、暑气为病等属于热证的病变相一致     

住院2型糖尿病患者血清促甲状腺激素水平与糖尿病视力受损风险的关系

目的 探讨2型糖尿病患者血清促甲状腺激素（TSH）水平与糖尿病视网膜病变、视力受损风险的关系.方法 住院2型糖尿病患者1003例,以TSH值进行四分位处理,观察不同TSH分位水平下患者视网膜病变及视力受损风险的差异.结果 4组不同TSH分位患者发生视网膜病变及视力损害风险均无显著性差异（P=0.943）.Logistic回归分别调整了年龄、性别、病程、收缩压、空腹血糖后,不同分位TSH组间的视网膜病变及视力损害风险无显著性差异.多因素调整后显示糖尿病视网膜病变同糖尿病病程、收缩压有关（P=0.000）.结论 住院2型糖尿病患者血清TSH水平与糖尿病视网膜病变、视力受损风险无明显相关.     

舟山海岛非碘盐食用人群的碘营养状况调查

目的 了解岱山县非碘盐食用人群的腆营养状况，为有关部门对海岛地区补碘提供科学依据。方法 调查岱山县妊娠28周以上的孕妇100人，通过饮食调查及尿碘检测，追踪检测孕妇、新生儿的脐带血的促甲状腺激素（TSH)水平，评价其碘营养状况。对岱山农村随机抽取4个乡的幼儿进行调查，对饮食碘摄入量和尿碘水平进行描述性统计及非参数检验，并进行相关分析。结果 孕妇饮食碘摄入量和尿碘水平中位数分别为291．3μg／d和79．3μg／d|L，新生儿TSH中位数为3μU／m1。幼儿饮食碘摄入量和尿碘水平的中位数分别为34．5μg／d和86．1μg／L。结论 应对海岛非碘盐食用人群采取补碘措施。     

Thyroid status in senile dementia of the Alzheimer type (SDAT)

Thyroid function was investigated in a group of 21 patients with severe senile dementia of the Alzheimer type (SDAT) and in a group of 17 age and sex matched normal controls. Free thyroid hormone levels (triiodothyronine (T3) and thyroxine (T4) were measured, as were also the thyrotrophin (TSH), prolactin (PRL) and growth hormone (GH) responses to thyrotrophin releasing hormone (TRH)). When compared to controls, patients demonstrated a significantly lower free T3 value (but not free T4), a blunted TSH response to TRH, slightly elevated basal PRL and GH values and a small GH response to TRH. However, all differences were small in biological terms and were within the laboratory's normal range. This emphasizes the relative normality of neuroendocrine function, particularly thyroid status, in SDAT.     

Effect of flunarizine on pituitary secretion by healthy men and in woman with migraine

Summary Flunarizine is widely used in the prophylaxis of migraine. It is both a calcium blocker and a histamine antagonist at H₁-receptors and either of these effects could alter hormonal secretion. The effect of administration of flunarizine to 8 women with common migraine on pituitary secretion has been studied. The dopamine antagonist domperidone (10 mg) and gonadotropin releasing hormone (100 µg) were injected iv before and after one month of flunarizine therapy (10 mg orally at bed-time).The basal prolactin level was significantly increased by the drug, and the peak induced by domperidone stimulation was reduced. Basal TSH concentrations were not affected, but the increase after domperidone was blunted.After 90 days of therapy there were no significant differences from the baseline concentration. Neither basal nor gonadotropin releasing hormone — stimulated secretion of FSH and LH were affected by flunarizine. Twelve healthy men were given placebo and flunarizine (10 mg at bedtime) for 5 days in single-blind fashion. Flunarizine caused a significant increase in prolactin and TSH with no effect on basal gonadotropin and thyroid hormone levels.These results can be accounted for by the calcium blocking effect of the drug, although weak interference with dopaminergic transmission is a further possibility explanation.     

自主性高功能性甲状腺腺瘤的外科治疗

目的探讨自主性高功能性甲状腺腺瘤的病因及外科治疗方法。方法回顾性分析10例自主性高功能性甲状腺腺瘤患者的临床资料。结果10例患者均无喉返神经、喉上神经损伤症状，无甲状腺危象发生结论术式应选择腺叶次全或全切除术     

The Response to TRH, LH-RH, Metyrapone and Vasopressin in Patients with Hypothalamo-Pituitary Disorders

Abstract. The effects of slow intravenous infusion of synthetic TRH on serum TSH and of synthetic LH-RH on serum LH measured by radioimmunoassay were studied in healthy persons and in 36 cases with sellar tumours and other hypo-thalamo-pituitary disorders. The results were also compared with the responses to oral metyrapone and intravenous infusion of lysine-8-vasopressin, as tests for the hypothalamo-pituitary-adrenal regulation. 200 μ g of TRH was found to give a mean increase of serum TSH of +10.4 μ/ml in eight males and of +15.7 μ/ml in nine females. LH-RH infusion was found to give a mean increase of serum LH of -f-1.78 ng/ml in six young males. The TRH test gave a pathologically low response in one out of nine patients with an intrasellar tumour. On the other hand in patients with a craniopharyngioma, which usually causes more pronounced pituitary destruction, the response was pathologically low in five out of six cases. A normal response to TRH was obtained in seven out of nine patients with disorders mainly affecting the hypothalamus. When twelve patients with pituitary adenomas were tested post-surgery six patients gave a pathologically low TRH response. The response to LH-RH was pathologically low in five out of eight cases with a pathologically low TRH response and normal in six out of six cases with a normal TRH response. However, there was a poor correlation between the results of these two tests and the vasopressin and metyrapone administration. This difference may be explained by the direct effect of the releasing hormones on the pituitary and the need for a certain hypothalamic function to obtain a response to the vasopressin and metyrapone tests.     

Pituitary tsh response to TRH: Interrelationships with gonadal activity

Summary A TSH radioimmunoassay is described, which was used to investigate the behaviour of the TSH pituitary response (as measured by the secretory area) to TRH in groups of subjects of both sexes and different phases of gonadal activity. It is concluded that the TSH pituitary response is in no way affected by physiological variations in the plasma gonadal hormones. This independent behaviour of the TSH response, uninfluenced by gonadal activity, was apparently confirmed by the results in some pathological conditions (ovarian agenesis and primary male hypogonadism of various types) characterized by very low plasma levels of gonadal hormones.     

Suppressive effects of minocycline on the pituitary-thyroid axis in humans

Minocycline has been thought to induce “black thyroid”, a condition marked by discoloration due to brown deposits. However, its effect on thyroid function in humans is still obscure. We conducted a prospective study of thyroid hormone levels in 17 patients who were administered 200 mg minocycline daily for 10 days. We found that minocycline significantly reduced the serum total thyroxine level (8.43±0.61 to 7.09±0.45 μg/dl, mean ± SEM;P<0.01), and free thyroxine level (1.12±0.10 to 1.01±0.08 ng/dl, mean ± SEM;P<0.01). There was also a slight, but insignificant, elevation of thyroid stimulating hormone (TSH) in patients treated with minocycline. Similar suppression of thyroxine and free thyroxine was not observed in control patients treated with β-lactam and/or aminoglycoside antibiotics. Risk factors for the reduction in these thyroxine levels included age and a high serum baseline level of free thyroxine. We found a significant correlation between the free baseline thyroxine level and a reduction in free thyroxine after minocycline administration (Y=0.420X−0.377, r=0.597;P<0.01). Despite the observed alterations, the serum levels of all thyroid hormones after minocycline therapy were still within the normal range. This antibiotic does not appear to induce clinical hypothyroidism, yet given the results of this study, we would like to recommend pituitary-thyroid axis monitoring during the use of this antibiotic.