动态血糖监测在初诊2型糖尿病治疗中有效性和安全性的研究

目前，对初诊的2型糖尿病国内外倾向于早期使用胰岛素治疗，使胰岛B细胞得到休息，使B细胞功能得到改善。但是，调整药物计量降低血糖的过程中，由于生化分析仪与快速血糖仪监测血糖受测试次数的限制，不能连续动态监测患者24h或     

腹部手术切口感染裂开简易二期缝合快速愈合23例临床观察

目的:探讨促进腹部手术切口感染裂开快速愈合方法,缩短住院时间。方法:观察组23例采用沿麻醉针孔引导缝针进行简易二期缝合方法,选择同期传统二期缝合23例和传统换药法23例作为对照组。结果:观察组切口愈合时间及术后住院天数,明显缩短于对照组。结论:简易二期缝合方法,能够快速愈合伤口,简单易行,并能明显缩短住院时间,缓解医患矛盾,具有临床推广应用价值。     

有问必答

青岛陈或读者：前些日子我孩子发高烧，专家诊断为胃肠型感冒，口服药几天后孩子的病就好了。请问，什么是胃肠型感冒？如何预防？     

全髋关节置换术患者围手术期的健康教育

全髋关节置换术后康复时间长，康复期如不保持正确的体位，即可能发生较多的并发症，如下肢静脉血栓、髋关节脱位、肺部感染等。针对病人个体情况，住院期间加强对患者及家属的健康教育，能提高患者疗效，防止发生并发症，缩短住院时间。现将2006年至2007年54例全髋关节置换术患者围手术期的健康教育报告如下。     

血必净联合罗格列酮对局灶节段性肾小球硬化大鼠肾脏的保护作用

局灶节段性肾小球硬化(FSGS)是多种肾小球疾病发展的共同病理途径.糖皮质激素作为治疗FSGS方案的核心药物,对肾病综合征的治疗发挥了巨大作用,但多数患者呈现激素耐药,且长期使用激素可导致明显的毒副作用.     

黄连解毒汤对MPTP帕金森小鼠的防治作用

目的观察黄连解毒汤(HJD)对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)所致帕金森病(PD)小鼠的防治作用。方法将45只C57BL小鼠随机分为3组:正常组、模型组和HJD组。模型组小鼠每天腹腔注射MPTP 30 mg/kg,连续5 d,制备PD模型;HJD组小鼠每天灌胃HJD 17.55 g/kg(生药量),连续15 d。应用爬杆、悬挂和游泳实验检测小鼠肢体运动功能;高效液相色谱-电化学法(HPLC-ECD)法检测小鼠脑纹状体多巴胺(DA)及其代谢产物二羟苯乙酸(DOPAC)和高香草酸(HVA)含量;分光光度法测定小鼠脑组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量。结果 HJD对小鼠肢体运动功能的减退和脑神经组织的代谢异常有不同程度的调节和改善作用。结论 HJD对MPTP所致帕金森小鼠有一定的防治作用。     

老年急性阑尾炎术后继发脑腔隙性脑梗塞围手术期处理

随着社会老龄化,老年急性阑尾炎的发病率逐年进行性增高,约占急性阑尾炎总数的10%。由于老年人的机体功能降低,常伴有高血压、冠心病等老年内科疾病,这给阑尾炎的围手术期的治疗带来许多不便与困难,且术后的并发症多。我院自2006年3月～     

Lubiprostone用于治疗OBD的Ⅲ期研究结果

Sucampo制药公司已报道了其胃肠道用药lubiprostone（Ⅰ）用于治疗慢性非癌痛患者阿片引起的肠功能紊乱（OBD）的两项Ⅲ期研究的主要结果。两项研究结果不     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

2型糖尿病患者卒中一级预防的现况调查

目的 了解2型糖尿病患者住院前及住院期间卒中各危险因素的干预状况，发现临床实践与证据之间的差距，提高临床医生对卒中一级预防的认识，指导今后的临床治疗。方法 本调查为横断面调查研究，回顾性调查167例2型糖尿病患者住院前及住院期间对卒中主要危险因素的干预情况。结果 被调查的患者中，入院前有46.7%的患者有高血压；36.0％的患者有吸烟史；19.8％的患者存在冠状动脉粥样硬化性心脏病，0.6％的患者有心房颤动；23.4％的患者有脂代谢异常。出院前有56.9％的患者被诊断高血压；81.4％的患者存在脂代谢异常。入院前与出院前对血压的药物干预率差异无统计学意义（分别为75.6%及80.0%，P >0.05）；入院前后的降脂治疗（分别为25.6%及69.1%，P <0.01）及降糖治疗（分别为82.0%及97.6%，P <0.01）的差异均有统计学意义。结论 2型糖尿病患者院前对危险因素干预的达标率较低，应加强2型糖尿病患者及临床医生对卒中一级预防的认识，提高卒中卒中相关危险因素的干预率。