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101.
Thrombolysis increases case fatality but reduces the proportion of disabled survivors in recent trials in acute ischaemic
stroke, although some trials show much higher mortality rates than others. One possible explanation for the different outcomes
between trials is that the treatment effect with thrombolysis varies with baseline prognostic factors such as stroke severity.
We examined the interaction between baseline risk and thrombolysis on outcome using individual patient data from the Multicentre
Acute Stroke Trial–Italy (MAST-I). A multiple logistic regression of the MAST-I data was performed to identify which factors,
identifiable at randomisation, most strongly predict a poor functional outcome. We then stratified the patients into those
with severe strokes and those with mild strokes and examined the effect of thrombolysis on (a) case fatality and (b) dependency
at 6 months after the stroke in the 157 patients who received streptokinase alone and the 156 controls. Streptokinase was
found to cause an absolute increase of about 3% in case fatality in both “severe” and “mild” strokes; however, there was a
12% reduction in the number of dead or dependent “mild” strokes but a 6% increase in “severe” strokes. The number of patients
was small, and therefore neither finding was statistically significant. In this exploratory analysis, the hazard with streptokinase
appears similar in “severe” and “mild” strokes, but the benefit may be greater in “mild” strokes. Thrombolysis may be more
effective in patients with “mild” strokes, but more information is required to confirm this hypothesis.
Received: 29 January 1999 Received in revised form: 13 April 1999 Accepted: 5 May 1999 相似文献
102.
Ultrasound densitometry has been measured in the os calcis of 31 stroke patients (14 women, 17 men), ages 46–87 years, to
determine whether bone density is lower than expected for normal subjects at this site, and to investigate whether or not
the stroke side has lower values than the nonstroke side. We have also measured a large control group of 268(39 men, 228 women)
subjects who showed similar values to other published data. Immobility is a known precursor to bone loss and so we also compared
ultrasound Stiffness Index with an index of mobility in 22 of the stroke patients. In healthy subjects, ultrasound densitometry
(measured as Stiffness) fell by 25% in females from 48–52 to 68–72 years. Stiffness (expressed as z-score) in patients with
stroke was low in females (P < 0.02) but not in males, but both stroke side and nonstroke side were equally low. Stiffness did not decline with time since
stroke, but did correlate with mobility after stroke, on the stroke (r = 0.73) and nonstroke (r = 0.62) side. The data suggest
that stroke patients, particularly females, have low bone density before the stroke event. The greater ultrasound Stiffness
with increasing mobility after stroke may suggest that active rehabilitation after stroke may produce denser bone.
Received: 30 July 1997 / Accepted: 10 June 1999 相似文献
103.
Quality of life of stroke survivors 总被引:3,自引:0,他引:3
Adaptation to stroke requires complex, long-term change in stroke survivors' lives. This study aimed at identifying those factors that influence quality of life (QOL) of geriatric stroke survivors 1–3 years post-discharge. The objectives were: to describe the overall quality of life of stroke survivors; to examine the relationships between sociodemographic variables, neurological variables, functional status, social support, perceived health status, depression, and overall QOL; and to determine the best predictors of QOL. Data were collected on 50 stroke survivors using a cross-sectional design and standardized questionnaires, including the Quality of Life Index, the Functional Independence Measure, the Social Support Inventory for Stroke Survivors and the Centre for Epidemiologic Studies Depression Scale. The overall quality of life of the study participants was low. The most important predictors of QOL were depression, marital status, quality of social support, and functional status. Depression was the strongest predictor of QOL. By employing a multi-dimensional perspective, this study confirmed that adaptation to stroke involves much more than physical function. Thus, rehabilitation programs for this group would be more effective if they are based upon a holistic approach. 相似文献
104.
Merlo J Lindberg G Lindblad U Lindgren A Råstam L Melander A 《European journal of clinical pharmacology》1999,55(1):69-76
Objective: To perform an ecological study in an effort to generate questions concerning the preventive impact of various cardiovascular
drugs on mortality from stroke and ischaemic heart disease (IHD) in the community, and to explore the association between
sales of nitrates and mortality from stroke and IHD.
Methods: Out-patient drug utilization (sales) of blood pressure lowering drugs, lipid lowering drugs and nitrates were categorized
in four groups of equal size by quartiles and compared with mortality from IHD and stroke, using the group of municipalities
with the lowest utilization as reference, from 1989 to 1993 in 283 of Sweden's 288 municipalities, by Poisson regression.
Adjustments were made for population size, age and gender proportions, the utilization rate of cardiovascular drugs other
than the tested drug group and location of the municipality.
Results: Compared with the group of municipalities with the lowest sales and adjusting only for population size, mortality from IHD
and stroke increased with the extent of utilization of blood pressure lowering drugs and nitrates. In contrast, mortality
decreased with increased utilization of lipid lowering drugs. After further adjustments by percentage of men, age structure,
geographical location (mid-points) of the municipalities, and, as a proxy for cardiovascular disease, the sales of cardiovascular
drugs other than the tested drug group, the increased risk associated with blood pressure lowering drugs disappeared, and
there was a dose-response association between sales of diuretics and old antihypertensives and decreasing mortality, sales
of nitrates continued to be associated with an increased risk, and the low mortality risk associated with sales of lipid lowering
drugs persisted.
Conclusion: Lipid lowering drugs may have a preventive impact in the general population, but the preventive impact of blood pressure
lowering drugs, with the exception of diuretics and old antihypertensives, may be low in many municipalities. The safety of
nitrates needs more investigation at the individual level.
Received: 16 April 1998 / Accepted in revised form: 10 November 1998 相似文献
105.
Guidotti M. Ciccone A. Garavaglia P. Pellegrini G. 《The Italian Journal of Neurological Sciences》1996,17(2):153-155
We followed up 107 patients experiencing a first-ever ischemic stroke after having been affected by essential hypertension for at least one year, in order to analyze the phenomenon of post-stroke blood pressure lowering. Of the 82 patients still surviving after three months of follow-up, 44 (54%) had normal arterial blood pressure values. There were no significant differences between these normotensive patients and the 38 with high blood pressure in terms of cerebrovascular risk factors or disability, but blood pressure normalized in 34 of the 54 patients experiencing a carotid stroke (63%) and in only 10 of the 28 experiencing vertebrobasilar stroke (36%) (p=0.035). These data may offer a starting point for further studies of the neurogenesis of arterial hypertension.
Sommario Al fine di analizzare il fenomeno della normalizzazione della pressione arteriosa dopo ictus cerebrale in pazienti prima ipertesi, abbiamo osservato 107 soggetti con primo ictus ischemico, che erano già precedentemente affetti da ipertensione arteriosa da almeno un anno. Degli 82 (77%) sopravvissuti a tre mesi di follow-up, 44 (54%) hanno mostrato una normalizzazione della pressione arteriosa. L'incidenza di fattori di rischio per malattia cerebrovascolare e disabilità grave non è risultata significativamente diversa nel gruppo degli ipertesi rispetto ai normotesi. Tuttavia la normalizzazione della pressione arteriosa è stata osservata in 34 dei 54 pazienti con ictus carotideo (63%) e solo in 10 dei 28 con ictus vertebrobasilare (36%) (p=0.035). Riteniamo che tali dati offrano uno spunto per ulteriori ricerche sulla genesi neurogena dell'ipertensione arteriosa essenziale.相似文献
106.
107.
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109.
益肾养心通督针法对中风患者载脂蛋白的影响:附27例临床疗效观察 总被引:2,自引:0,他引:2
目的 观察益肾养心通督针法对中风患者载脂蛋白及临床疗效的影响。方法与结果 将 5 0例中风患者的载脂蛋白A(Apo A1 )、载脂蛋白 B(Apo B1 0 0 )与正常人比较 ,再将 5 0例中风患者随机分为益肾养心通督组 2 7例 (观察组 )和阳明经穴组(对照组 ) 2 3例 ,均治疗 30 d,观察治疗前后 Apo A、B变化 ,神经功能缺损积分及总体疗效。针刺后 Apo A1 升高 Apo B1 0 0 降低 ,神经缺损评分较治疗前大幅度降低。两组比较存在显著性差异 (P<0 .0 1)。结论 在改善载脂蛋白水平和临床疗效方面 ,观察组都优于对照组 (P<0 .0 5 ) 相似文献
110.
通关利窍针法治疗中风致假性延髓麻痹临床观察 总被引:8,自引:0,他引:8
目的 观察通关利窍针法治疗中风致假性延髓麻痹的疗效。方法 将 10 0例患者随机分为治疗组和对照组各 5 0例 ,治疗组采用通关利窍针法 ,对照组采用康复训练法 ,均 14次为 1个疗程 ,疗程间休息 3日 ,2个疗程后评定疗效。结果 治疗组总有效率 96 .4 % ,对照组 2 4 % ,两组差异有显著性意义 (P<0 .0 5 ) ,治疗组疗效和年龄、病程、病情轻重有关。结论 通关利窍针法治疗中风后假性延髓麻痹优于康复训练法 相似文献