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81.
Fear and the startle reflex: Blink modulation and autonomic response patterns in animal and mutilation fearful subjects 总被引:7,自引:1,他引:6
The present study was designed to examine the pattern of startle reflex modulation and autonomic responses for individuals high in animal or blood-injury fear when viewing pictures of their feared objects. Sixteen individuals in each fear group and 16 low-fear control individuals viewed 32 color slides depicting fear-relevant, unpleasant but fear-unrelated, neutral, and pleasant scenes. Free viewing times were assessed in a second phase of the procedure as an index of avoidance behavior. Exposure to pictures of feared objects resulted in a consistent startle reflex potentiation and behavioral avoidance in both fear groups. This activation of the basic aversive system was independent of the autonomic pattern of the fear responses, which differed for the high-fear groups. These results suggest that the probe startle response indexes the organism's basic motivational disposition and add new information to the assessment of fear. 相似文献
82.
K. Hoshi 《Advanced drug delivery reviews》1996,20(2-3):171-176
For its peripheral vascular dilating effect and platelet agglutination inhibitory activity, prostaglandin E1 is used in the treatment of diseases which are likely to cause peripheral circulatory failure or thrombus. In Japan, lipo-PGE1, which was developed to give it a target-directed nature by modifying the conventional PGE1, has been used and found to be useful in clinical practice. In this report, we attempt to describe the clinical benefits of lipo-PGE1 focusing on the diseases which have been approved for its indications. 相似文献
83.
84.
作者选择乙基纤维素、聚乙烯醇等高分子材料制成涂膜剂,用大鼠皮进行双氯灭痛药膜的体外透皮速率测定。结果表明,氮酮与丙二醇可以促进药物渗透。不同的高分子材料可影响药物的扩散与释放,从而影响其透皮速率。与无膜无促透剂处方相比,药物在乙基纤维素中的透皮速率没有增加,在聚乙烯醇膜中的透皮速率有显著增加。 相似文献
85.
目的 :研究肺表面活性物质 (PS)治疗新生儿呼吸窘迫综合征 (NRDS)前后血管内皮分泌功能变化及可能的治疗机理。方法 :用PS制剂固尔苏治疗 18例NRDS患儿 ,于治疗前 3 0min ,治疗后 1、 6、 12、 2 4h ,用硝酸还原酶法测定NO (一氧化氮 )、放射免疫法测定ET (内皮素 )、 6 K PGF1α (6 酮前列环素 )。结果 :固尔苏治疗后患儿NO、 6 K PGF1α明显升高 ,ET明显下降 ,与治疗前比较有显著性差异 (P <0 0 1)。治疗后 1、 6、 12、 2 4hNO、6 k PGF1α、ET各组间两两比较无明显差异 (P >0 0 5 )。结论 :PS治疗NRDS的机理可能是通过改善血管内皮功能发挥作用 ,为用外源性NO吸入和静注前列环素辅助治疗NRDS提供可能的实验依据。 相似文献
86.
G. Borkowski H. Sudhofft H. Luckhauptt S. Philippou H. Hildmann 《European journal of plastic surgery》1997,20(2):107-109
Dermatofibrosarcoma protuberans (DFSP) previously called Morbus Darier is an intermediate grade sarcoma with a fairly high rate of recurrence, it occurs most commonly on the trunk and extremities but may also occur in the head and neck region. Treatment of choice is wide excision. A 69-year-old female patient with a 57-year history of dermatofibrosarcoma protuberans is presented. The lesion appeared on the right forehead and both eyelids at the age of 12 years. The patient required 64 surgeries mostly for the head and neck lesions. 相似文献
87.
报告应用微粒皮肤移植技术抢救成功7例特大面积烧伤病人。文中介绍了手术方法、注意事项,指出了本术式的优缺点,并对该领域国内外的发展状况,作了简单叙述。 相似文献
88.
Identification of Babesia bigemina infected erythrocyte surface antigens containing epitopes conserved among strains 总被引:4,自引:0,他引:4
SANKALE SHOMPOLE TERRY F. McELWAIN DOUGLAS P. JASMER STEPHEN A. HINES JOSEPH KATENDE ANTHONY J. MUSOKE FRED R. RURANGIRWA TRAVIS C. McGUIRE 《Parasite immunology》1994,16(3):119-127
The presence of previously uncharacterized antigens (new antigens) on the surface of intact erythrocytes infected with three strains of Babesia bigemina from Kenya and one each from Puerto Rico, Mexico, St. Croix, and Texcoco-Mexico was demonstrated by indirect immunofluorescent antibody (IFA) reactions. These antigens were not strain specific because antibodies in bovine immune serum to either the Mexico or Kenya isolates reacted with all seven strains tested. Homologous and heterologous immune serum antibodies bound a maximum of 83% and 55%, respectively, of intact erythrocytes infected with the Kenya-Ngong strain but not uninfected erythrocytes. Both sera caused agglutination of only infected erythrocytes. Antibodies eluted from the surface of glutaraldehyde (0.25%) fixed infected erythrocytes had IFA reaction patterns among strains similar to those of immune sera before elation. Eluted antibodies were used to determine if these antigens were protein and encoded by B. bigemina. Eluted antibodies bound seven parasite-encoded proteins of 240, 220, 66, 62, 58, 52 and 38 kDa in an erythrocyte surfacespecific immunoprecipitation reaction of 35-methionine labelled proteins. It was concluded that the surface of B. bigemina infected erythrocytes had parasite-encoded proteins and that these proteins had surface exposed epitopes that were conserved among the seven strains examined which were from two continents. 相似文献
89.
90例毛母质瘤的临床病理分析 总被引:1,自引:0,他引:1
对90例毛母质瘤进行分析。结果显示,女性多于男性,男女之比1:2.1。此瘤以20~40岁多见,计43例(47.7%),20岁以下39例(43.3%),40岁以上8例(9.0%)。60%病例伴有钙化,35%有骨化,25.5%有含铁血黄素或黑色素沉着。局部损伤与本病发生相关,故认为局部损伤可能是本病的主要成因之一。对此瘤临床与病理诊断进行讨论。 相似文献
90.
采用ELISA法检测104例各类型乙型肝炎(乙肝)患者的血清前-S2抗原(Pre-S2Ag)及其抗体(Pre-S2Ab),结果表明,Pre-S2Ag的出现与HBsAg、HBeAg、HBcAb呈显著相关性(P值均<0.005),主要见于乙肝急性期及慢性乙肝患者,说明病毒复制活跃、传染性强。而Pre-S2Ab阳性仅见于急性乙肝恢复期。 相似文献