烟酰胺对家兔窦房结细胞动作电位的影响及其机制探讨

在离体家兔窦房结标本上,应用微电极技术,观察到NIC(4000 mg/L)使窦房结细胞动作电位的SP₄平均增加62%(P<0.01);SCL平均减少27%(P<0.01);APD₉₀平均减少12%(P<0.05);APA,SP₀无显著变化。VER(0.1 mg/L)可完全阻断NIC的作用,但对ISO(0.03mg/L)的作用无明显影响;PRO(0.25 mg/L)可完全阻断ISO的作用,但NIC的作用不受影响。实验结果提示,NIC可能是一个钙通道激活剂,通过促进i_si而增加窦性频率。     

Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) presenting with skeletal lesions

A 2-year-old child presenting with bone pain and bone lesions was found to have sinus histiocytosis with massive lymphadenopathy (SHML). SHML presenting with skeletal symptoms is unusual. Management has been conservative and the child has been symptom free for 30 months, although the bone lesions have not completely regressed.     

内镜辅助下对鼻窦恶性肿瘤的治疗

目的:探讨鼻内镜辅助治疗鼻窦恶性肿瘤的临床效应.方法:选取2008年7月至2009年9月于我院治疗的鼻窦恶性肿瘤患者68例,其中38例行内镜辅助下鼻窦恶性肿瘤切除术,为实验组;30例行普通鼻镜辅助下鼻窦恶性肿瘤切除术,为对照组,肿瘤切除后均给予常规化疗治疗,将两组患者的一般资料及临床效果进行统计分析.结果:经过2年随访,实验组复发并再次手术治疗3例,占7.89%,2年内死亡2例,占5.26%,2年内生存36例,占94.74%;对照组复发并再次手术治疗9例,占30%,2年内死亡8例,占26.67%,2年内生存22例,73.33%.两组患者随访资料经统计学分析,均P＜0.05,差异具有统计学意义.结论:内窥镜辅助下治疗鼻窦恶性肿瘤的临床疗效明显优于普通鼻镜辅助治疗效果,具有明显差异,值得临床推广应用.     

心脏再同步治疗在心功能不良伴心房颤动患者中的临床疗效分析

目的 探讨心房颤动（房颤）患者经过房室结消融后心脏再同步治疗(CRT)的临床疗效。方法 将80例在本院接受CRT的心功能不良患者按术前心律分为两组：房颤组（15例）、窦性心律组(65例),房颤组患者在CRT治疗同时行房室结消融。房室结消融和CRT术前收集患者基本信息如年龄、性别、心功能（NYHA分级）、病程、糖尿病和高...     

Rosai-Dorfman disease mimicking meningiomatosis: a case report

Rosai-Dorfman disease (RDD), also known as sinus histocytosis with massive lymphadenopathy, is a rare idiopathic histioproliferative disease affecting the lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system manifestations, particularly in the absence of nodal disease with clinical and radiological findings suggestive of meningioma, are extremely rare. Histopathology and immunohistochemistry are essential for a positive diagnosis. We report a case of RDD in a patient presenting multiple meningeal nodules with a review of the literature and discussion of differential diagnosis.     

Computed tomography scans of paranasal sinuses before functional endoscopic sinus surgery

This review aims to familiarize the radiologist with the common types of sinus surgery including their indications and techniques.We also illustrate how surgeons interpret 3D sinus anatomy when evaluating computed tomography(CT)studies.Preoperative evaluation by CT is mandatory for all patients undergoing functional endoscopic sinus surgery(FESS).In the past decade in particular,CT of the paranasal sinuses has become a roadmap for FESS.The radiologist’s goal is to report on five key points:the extent of sinus opacification,opacification of sinus drainage pathways,anatomical variants,critical variants,and condition of surrounding soft tissues of the neck,brain and orbits.We present a systematic approach to the use of coronal,axial,and sagittal images in CT evaluation before FESS.     

Permanent Blindness after Endoscopic Sinus Surgery

Few cases of ophthalmic complications have been reported following sinus endoscopic surgery with current techniques. Irreversible damage to orbital structures was found in a 21-year-old patient referred to our department for evaluation after sinus endoscopic surgery and ipsilateral amaurosis.     

Giant extracardiac unruptured sinus of Valsalva aneurysm in a patient with left ventricular dysfunction

Extracardiac unruptured sinus of Valsalva aneurysm (SVA) is an infrequent cardiac anomaly. Unruptured SVAs are typically symptom-free until rupture occurs. We describe a case of an unruptured extracardiac SVA originating from noncoronary sinus with left ventricular dysfunction. The patient was asymptomatic. The diagnosis was made by transthoracic echocardiography, computed tomography, and cardiac catheterization. The aneurysm was surgically resected and the sinus was successfully reconstructed with a patch. The patient remained asymptomatic throughout the postoperative follow-up period. Early surgical repair should be the choice of treatment for extracardiac SVAs in order to prevent sudden death.