Sinus histiocytosis with massive lymphadenopathy: A case of multiple dural involvement

An exeptional case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) arising from the meninges in a 60-year-old Japanese man is presented. Computerized tomographic scans and magnetic resonance images demonstrated well-circumscirbed tumorous lesions that were homogeneously enhanced with contrast medium. Systemic examination revealed no abnormalities except for a cervical lymphadenopathy and diabetes mellitus. Microscopic examination of the resected specimens showed proliferated histiocytosis and infiltration of plasma cells and lymphocytes. The histology was characterized by the presence of histiocytes demonstrating lymphophagocytosis and immunoreactivity for S-100 protein staining. Immunohistochemical studies and electron microscopy were useful in confirming the diagnosis. The clinical and histopathological features of this disease are discussed.     

Gradient recalled echo MR imaging of superior sagittal sinus occlusion

Summary With T1-weighted gradient recalled echo (GRE) MR images and flow compensation, we studied the superior sagittal sinus in 3 normal volunteers and 3 patients with sinus occlusion. In these images, sites of patency of the superior sagittal sinus were identified due to the high signal intensity of the normal sinus. Tumor invading the sinus was nearly isointense with cerebral gray matter. T1-weighted GRE imaging proves to be an effective technique to evaluate sinus blood flow.     

Light and transmission electron microscopic studies following frontal sinus obliteration with ionomer cement in cats

Osteoplastic frontal sinus surgery in combination with sinus obliteration can be performed for various indications, including chronic sinusitis, frontal sinus trauma and removal of osteomas. In an experimental study using cats, the mucous lining of the frontal sinus was removed, the nasofrontal duct sealed with semifluid ionomer cement and the cavity filled with Ionogran, a solid and porous bone substitute based on ionomer cement. Histological investigations up to 1 year after surgery showed increasing sinus obliteration by regenerating bone, starting from the sinus wall, and formation of connective tissue between the cement grains. There was no evidence for mucosal regeneration. Electron microscopic examination of the interface between the cement and connective tissue revealed mesenchymal cells, collagen fibers and areas of mineralization in close contact with the implant material. Newly formed connective tissue matrix in intimate contact with the cement was a good indication for biocompatibility of the material and is a possible explanation for the implant's solid adhesion to bone. The present findings indicate that lonogran is a suitable alloplastic material for experimental frontal sinus obliteration in cats.Adapted from a presentation of preliminary results reported at the 65th annual meeting of the German Society for Otorhinolaryngology — Head and Neck Surgery (Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie), Chemnitz (Germany), 14–18 May 1994     

Chrome congestive heart failure: Complete sinus arrest during diltiazem therapy; clinical correlates and efficacy of intravenous calcium

The occurrence of severe sinus node dysfunction in 10 patients(three males and seven females; mean age 78·5±3·4,range 57–92 years) receiving oral diltiazem therapy (mean190±20 mgl24 h, range 90–300) is described Sixof them were concomitantly taking amiodarone andlor beta-blockingagents. On admission, seven patients exhibited systemic hypotensionand nine complained of asthenia and/or dizziness or drowsiness.ECG findings showed in all a persistent sinus arrest with atrial,junctional or ventricular escape, leading to a mean heart rateof 40·2±3 beats. min^–1 (range 257ndash;56).All patients had chronic renal failure on biological tests,with a mean endogenou.s creatinine clearance of 25±3ml. min^–1 (range 12–36). Intravenous calcium hydrochloride(mean 1·4±0·2 g, range 1–2), givenin nine patients, rapidly restored stable sinus activity inseven. We suggest that diltiazem should be given cautiouslyto ageing patients with chronic renalfailure, and confirm theefficacy of intravenous calcium in reversing calcium channelblocker toxicity on sinus node.     

Inferior sinus venosus defect associated with incomplete cor triatriatum dexter and patent foramen ovale.

Sinus venosus atrial septal defect (SVD) is a rare cardiac abnormality in adults. Particularly, the inferior type is difficult to depict by transthoracic echocardiography because of its infero-posterior location to the fossa ovalis. We describe the case of a 33-year-old woman whose chest X-ray taken during bronchopneumonia revealed a cardiomegaly. Further echocardiographic investigations showed an underlying inferior SVD, an incomplete cor triatriatum dexter and a large patent foramen ovale (PFO). The diagnosis was confirmed by cardiac magnetic resonance imaging (CMR) and during surgical repair.     

Effect of histamine in sinus node arrested with reserpine

Summary Histamine restored spontaneous activity in the isolated rabbit sinus node arrested with reserpine. This fact suggests that catecholamines are not the unique activators of adenylate cyclase required for cardiac pacemaking, and may be replaced by histamine.     

右心房上部心律的确诊

为探讨右心房上部心律的诊断方法，通过动物实验自身对照，同步记录１５只犬心电图Ⅱ、ａＶＲ导联、心腔内窦房结电图、高位右心房电图。结果发现在窦房结局部注入维拉帕米、石碳酸及电刺激右侧颈迷走神经情况下，窦房结功能被抑制后出现房性逸搏心律时，心电图有时仍为窦性心律（ＰⅡ直立、ＰａＶＲ倒置）；而窦房结电图上则记录不到窦房结电位，心率亦有明显降低（ｔ＝２．４２０，Ｐ〈０．０５）。提示窦房结附近的右心房上部心律     

Unusual ``Midseptal' Sinus Venosus Defect

An unusual case of an interatrial communication similar to a sinus venosus defect associated with an overriding pulmonary venous chamber is reported. There was no direct connection of the pulmonary venous system with either the superior vena cava or the low right atrium, as is usual with sinus venosus defects. This defect may represent the result of a sinus venosus defect associated with cor triatriatum.     

Reactive hyperplasia of paracortex and germinal centers of the regional lymph nodes in gastric carcinoma cases as a favorable prognostic indicator

The prognosis of 141 patients subjected to curative resection for gastric carcinoma was analyzed with special reference to the paracortex, germinal centers and sinus histiocytes in the regional lymph nodes. Five year survival rates of the patients with paracortical and/or germinal center hyperplasia (PH and/or GH) was definitely superior to those without such hyperplasia. This difference was most pronouced in those with moderately advanced stage. The incidence of lymph node metastasis was lower in the patients with PH or GH. The presence of sinus histiocytosis (SH) seemed to be correlated neither with a longer survival nor with lower incidence of lymph node metastasis. No close correlation was found between Ph, GH and SH on one hand and histological types of the primary gastric carcinomas on the other. These results suggest that cell mediated and/or humoral immune response may play an important role in host resistance against gastric carcinoma.