噻托溴铵粉吸入剂治疗148例支气管扩张症的效果评定

目的观察噻托溴铵粉吸入剂应用于临床治疗支气管扩张症的效果。方法选取我院治疗的148例支气管扩张症患者,随机分为观察组和对比组,对比组给予常规的支气管扩张症治疗;观察组在进行常规治疗的同时给予噻托溴铵粉吸入剂进行治疗。结果治疗后观察组和对比组的BODE指数和临床症状均有改善,但观察组优于对比组,P0.05,差异具有统计学意义。结论使用噻托溴铵粉吸入剂治疗支气管扩张症疗效显著。     

青黛粉联合抗生素治疗糖尿病皮肤感染疗效观察

目的:观察青黛粉联合抗生素治疗糖尿病皮肤感染的临床疗效。方法:选取2009年1月~2012年1月期间在本院皮肤科住院治疗的80例糖尿病皮肤感染患者为研究对象,采用分组对照法,观察组40例采用青黛粉+红霉素敷料换药,对照组40例单纯采用红霉素敷料,回顾性分析两种用药方法的效果。结果:治疗7d后观察组8例(占20%)患者感染创面为重度,对照组为2例(占5%),组间比较μ=3.221,7.609,P<0.05,观察组51个创面,总有效率为90.56%,对照组53个创面,总有效率为84.51%,μ=1.879,P<0.05,提示青黛粉联合抗生素治疗糖尿病皮肤感染疗效显著好于未加青黛粉的对照组,差异显著,有统计学意义。结论:加用青黛粉的观察组疗效显著好于单纯使用抗生素的对照组,有助于缩短疗程,加快皮肤感染组织的修复,促进早期愈合,疗效确切,值得临床推广应用。     

生脉散合血府逐瘀汤治疗冠心病气阴两虚血瘀证的临床疗效观察

目的 观察应用生脉散联合血府逐瘀汤治疗冠心病气阴两虚血瘀证的效果。方法 选取2016年1月—2017年12月我院心内科收治的冠心病患者100例，根据入院顺序平均分为常规组和研究组，常规组患者实施常规西医治疗，研究组患者加用生脉散联合血府逐瘀汤治疗，观察两组的治疗效果及相关指标。结果 研究组患者的治疗有效率为90%，明显高于常规组的74%(P＜0.05)；两组患者治疗后的中医症状积分、心绞痛发作次数和6 min步行试验均明显优于治疗前(P＜0.05)，且研究组患者治疗后3个指标更优(P＜0.05)。结论 生脉散联合血府逐瘀汤可以提高临床冠心病气阴两虚血瘀证的治疗效果，缓解患者症状和心绞痛发作，有助于6 min步行试验改善。     

柴胡疏肝散联合四君子汤治疗慢性萎缩性胃炎的临床效果

目的研究柴胡疏肝散联合四君子汤治疗慢性萎缩性胃炎(CAG)的临床效果。方法将2014年10月至2019年10月于我院治疗的96例CAG患者随机分为对照组和研究组,各48例。对照组给予柴胡疏肝散治疗,研究组在对照组基础上加用四君子汤治疗。比较两组患者的临床疗效、Hp根除率、胃镜病理检查评分、症状积分及生活质量。结果研究组治疗总有效率及Hp根除率明显高于对照组(P<0.05)。治疗后,两组胃镜病理检查评分、主要症状积分和次要症状积分均降低,GQOL-74各项评分均提高,且研究组显著优于对照组(P<0.05)。结论柴胡疏肝散联合四君子汤治疗CAG可显著改善患者胃部病理状态和临床症状,提高临床疗效、Hp根除率和患者生活质量,值得临床推广应用。     

毫火针联合中药药膜外敷治疗轻中度痤疮疗效观察

目的:探讨毫火针联合中药药膜外敷治疗轻中度痤疮患者的临床效果和安全性。方法:将100例门诊确诊为轻中度痤疮的患者随机分成两组。治疗组:50例,使用毫火针配合中药药膜外敷治疗(每周2次,8周为1个疗程);对照组:50例,仅采用毫火针治疗(每周2次,8周为1个疗程),治疗1个疗程后观察两组的治疗效果及安全性。结果:治疗组:治愈6例,显效19例,有效22例,总有效率94.0%;对照组:治愈3例,显效12例,有效25例,总有效率80.0%,两组疗效比较差异有统计学意义(P<0.05)。治疗后,治疗组患者DLQI积分为2.52±0.81,显著低于对照组,差异具有统计学意义(P<0.05);治疗后,治疗组患者的DLQI积分下降幅度显著高于对照组,差异具有统计学意义(P<0.05)。治疗期间,治疗组发生不良反应1例,发生率为2%;对照组未发现明显不良反应,差异无统计学意义(P>0.05)。结论:毫火针联合中药药膜外敷治疗轻中度痤疮安全、有效。     

Formulation of a novel fixed dose combination of salmeterol xinafoate and mometasone furoate for inhaled drug delivery

Co-administration of an inhaled corticosteroid and long acting beta agonist for chronic obstructive pulmonary disease has reduced mortality compared to either drug alone. This combination reduces exacerbations, hospitalization, emergency department visits and health care costs. A novel fixed-dose combination of the long acting beta-2 agonist salmeterol xinafoate (SX) and the corticosteroid mometasone furoate (MF) were prepared in a composite particle formulation as brittle matrix powder (BMP) and investigated for suitability as an inhaled combination product. In this study, BMP fixed dose combinations of SX and MF with or without stabilizing excipients (lactose, mannitol, glycine and trehalose) were prepared and characterized with respect to their thermal properties, morphology, aerodynamic performance and physical stability. BMP combination formulations of SX and MF exhibited improved aerodynamic properties when delivered by dry powder inhalation as compared to the micronized blends of the same substances. Aerodynamic evaluation was carried out by next generation pharmaceutical impactor (NGI) with a marketed DPI device. Results demonstrated that co-deposition occurred when SX and MF were formulated together as composite particles in a BMP, while physical blends resulted in inconsistent deposition and dose uniformity. As a result of the bottom-up particle engineering approach, combination BMP formulations allow for dual API composite formulations to be dispersed as aerosolized particles. Aerosolized BMP combination formulations resulted in delivered dose uniformity and co-deposition of each API. Further, an excipient-free formulation, BMP SXMF, delivered approximately 50% of the loaded dose in the respirable range and demonstrated stability at ambient conditions for 6 months. Single dose 24-h pharmacokinetic studies in rats demonstrated that lung tissue deposition and blood circulation (AUC_0–24h) of two APIs were higher for the BMP combination group exhibiting a significantly higher lung concentration of drugs than for the crystalline physical blend. While high system drug levels are generally undesirable in lung targeted therapies, high blood levels in this rodent study could be indicative of increased pulmonary tissue exposure using BMP formulations.     

蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗小儿急性腹泻的临床分析

目的探讨蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗小儿急性腹泻的临床疗效。方法选取我院自2013年2月~2014年2月接收的80例小儿急性腹泻患儿,随机分为观察组和对照组,每组40例,对照组行单纯蒙脱石散治疗,观察组则行蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗,比较两组患儿的临床疗效。结果 两组患儿治疗总有效率、退热时间、呕吐消失时间、腹痛消失时间、大便正常时间等比较均有显著性差异(P0.05)。结论 给予急性腹泻患儿蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗可有效的提高治疗效果,改善患儿临床症状。     

Influence of debittered,defatted fenugreek seed powder and flaxseed powder on the rheological characteristics of dough and quality of cookies

A functional ingredient mix (FIM) comprising debittered and defatted fenugreek seed powder (70%) and flaxseed powder (30%) was used in cookies. Ash, fat and protein, dough development time, resistance to extension and peak viscosity values increased as the level of FIM increased from 10 to 30% in the blend. Beyond 20% of FIM substitution, the quality characteristics of cookies were adversely affected. Use of soya lecithin produced a significant improvement in the overall quality of the cookies with 20% FIM. Linolenic acid and total dietary fiber content of the cookies with 20% FIM and lecithin contained four times the amount of linolenic acid (2.3%) and double the amount of dietary fiber (13.04%) when compared with the control cookies (0.5% and 6.22%) respectively. Surface scanning electron microscopy of cookies with different levels of FIM from 10 to 30% showed that there was a disruption in the matrix.     

短期去乳糖奶粉喂养方法对新生儿腹泻的效果

目的：探讨短期去乳糖奶粉喂养方法对新生儿腹泻的效果。方法选取2013年3月—2014年2月腹泻患儿140例，按随机数字表法随机分为观察组和对照组各70例，观察组采用短期去乳糖奶粉喂养，对照组采用长期去乳糖奶粉喂养。比较两组患儿治疗效果、胃肠道症状、体质量增长与喂养耐受情况。结果观察组患儿痊愈51例，有效17例，无效2例；对照组痊愈47例，有效20例，无效3例，差异无统计学意义（Z＝0．758，P＝0．366）。观察组患儿平均体质量增长（34．30±7．35）g／（kg· d），平均摄入奶量（105．37±24．02）ml／（kg· d），优于对照组的（24．29±8．06）g／（kg· d），（97．21±21．66）ml／（kg· d），差异有统计学意义（t值分别为2．809，3．161；P＜0．05）。观察组排便次数、呕吐、腹胀、胃潴留发生例数均少于对照组，差异有统计学意义（P＜0．05）。结论腹泻新生儿采取短期去乳糖奶粉喂养方式既符合婴幼儿的生长发育特点，又可以维持其免疫功能的平衡，且经济实惠，值得在临床推广。