To identify incorrect inhaler techniques employed by patients with respiratory
diseases in southern Brazil and to profile the individuals who make such errors.
METHODS:
This was a population-based, cross-sectional study involving subjects ≥ 10 years
of age using metered dose inhalers (MDIs) or dry powder inhalers (DPIs) in 1,722
households in the city of Pelotas, Brazil.
RESULTS:
We included 110 subjects, who collectively used 94 MDIs and 49 DPIs. The most
common errors in the use of MDIs and DPIs were not exhaling prior to inhalation
(66% and 47%, respectively), not performing a breath-hold after inhalation (29%
and 25%), and not shaking the MDI prior to use (21%). Individuals ≥ 60 years of
age more often made such errors. Among the demonstrations of the use of MDIs and
DPIs, at least one error was made in 72% and 51%, respectively. Overall, there
were errors made in all steps in 11% of the demonstrations, whereas there were no
errors made in 13%.Among the individuals who made at least one error, the
proportion of those with a low level of education was significantly greater than
was that of those with a higher level of education, for MDIs (85% vs. 60%; p =
0.018) and for DPIs (81% vs. 35%; p = 0.010).
CONCLUSIONS:
In this sample, the most common errors in the use of inhalers were not exhaling
prior to inhalation, not performing a breath-hold after inhalation, and not
shaking the MDI prior to use. Special attention should be given to education
regarding inhaler techniques for patients of lower socioeconomic status and with
less formal education, as well as for those of advanced age, because those
populations are at a greater risk of committing errors in their use of
inhalers. 相似文献
Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers.
Areas covered: The consequences of the choices made for early DPI development with respect of efficacy, production costs and safety and the tremendous amount of energy put into understanding and controlling the dispersion performance of adhesive mixtures are discussed. Also newly developed particle manufacturing and powder formulation processes are presented as well as the challenges, objectives, and new tools available for future DPI design.
Expert opinion: Improved inhaler design is desired to make DPIs for future applications cost-effective and safe. With an increasing interest in high dose drug delivery, vaccination and systemic delivery via the lungs, innovative formulation technologies alone may not be sufficient. Safety is served by increasing patient adherence to the therapy, minimizing the use of unnecessary excipients and designing simple and self-intuitive inhalers, which give good feedback to the patient about the inhalation maneuver. For some applications, like vaccination and delivery of hygroscopic formulations, disposable inhalers may be preferred. 相似文献