全文获取类型
收费全文 | 31370篇 |
免费 | 2324篇 |
国内免费 | 2618篇 |
专业分类
耳鼻咽喉 | 275篇 |
儿科学 | 409篇 |
妇产科学 | 85篇 |
基础医学 | 3829篇 |
口腔科学 | 319篇 |
临床医学 | 2481篇 |
内科学 | 5790篇 |
皮肤病学 | 132篇 |
神经病学 | 2299篇 |
特种医学 | 1521篇 |
外国民族医学 | 1篇 |
外科学 | 3727篇 |
综合类 | 4418篇 |
预防医学 | 1711篇 |
眼科学 | 246篇 |
药学 | 2808篇 |
11篇 | |
中国医学 | 2327篇 |
肿瘤学 | 3923篇 |
出版年
2024年 | 81篇 |
2023年 | 431篇 |
2022年 | 955篇 |
2021年 | 1215篇 |
2020年 | 996篇 |
2019年 | 866篇 |
2018年 | 806篇 |
2017年 | 843篇 |
2016年 | 1021篇 |
2015年 | 1172篇 |
2014年 | 2172篇 |
2013年 | 2466篇 |
2012年 | 1937篇 |
2011年 | 2054篇 |
2010年 | 1660篇 |
2009年 | 1642篇 |
2008年 | 1819篇 |
2007年 | 1756篇 |
2006年 | 1655篇 |
2005年 | 1397篇 |
2004年 | 1038篇 |
2003年 | 922篇 |
2002年 | 835篇 |
2001年 | 757篇 |
2000年 | 693篇 |
1999年 | 575篇 |
1998年 | 471篇 |
1997年 | 469篇 |
1996年 | 427篇 |
1995年 | 395篇 |
1994年 | 336篇 |
1993年 | 308篇 |
1992年 | 228篇 |
1991年 | 238篇 |
1990年 | 176篇 |
1989年 | 186篇 |
1988年 | 140篇 |
1987年 | 115篇 |
1986年 | 84篇 |
1985年 | 128篇 |
1984年 | 88篇 |
1983年 | 76篇 |
1982年 | 81篇 |
1981年 | 65篇 |
1980年 | 79篇 |
1979年 | 81篇 |
1978年 | 53篇 |
1977年 | 49篇 |
1976年 | 42篇 |
1973年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
11.
Ragnhild B. Wijma Marloes Emous Merel van den Broek Anke Laskewitz Anneke C. Muller Kobold André P. van Beek 《Surgery for obesity and related diseases》2019,15(1):73-81
Background
Early dumping is a poorly defined and incompletely understood complication after Roux-en-Y gastric (RYGB).Objective
We performed a mixed-meal tolerance test in patients after RYGB to address the prevalence of early dumping and to gain further insight into its pathophysiology.Setting
The study was conducted in a regional hospital in the northern part of the Netherlands.Methods
From a random sample of patients who underwent primary RYGB between 2008 and 2011, 46 patients completed the mixed-meal tolerance test. The dumping severity score for early dumping was assessed every 30 minutes. A sum score at 30 or 60 minutes of ≥5 and an incremental score of ≥3 points were defined as indicating a high suspicion of early dumping. Blood samples were collected at baseline, every 10 minutes during the first half hour, and at 60 minutes after the start.Results
The prevalence of a high suspicion of early dumping was 26%. No differences were seen for absolute hematocrit value, inactive glucagon-like peptide-1, and vasoactive intestinal peptide between patients with or without early dumping. Patients at high suspicion of early dumping had higher levels of active glucagon-like peptide-1 and peptide YY.Conclusion
The prevalence of complaints at high suspicion of early dumping in a random population of patients after RYGB is 26% in response to a mixed-meal tolerance test. Postprandial increases in both glucagon-like peptide-1 and peptide YY are associated with symptoms of early dumping, suggesting gut L-cell overactivity in this syndrome. 相似文献12.
13.
Haonan Guo Rui Zhang Justice Afrifa Yuanyuan Wang Jingcui Yu 《Pathology, research and practice》2019,215(6):152403
PurposeWe previously demonstrated that the functional inactivation of DAL-1 and TOB1 promotes an aggressive phenotype in gastric cancer cells, but the links between both genes and the survival of patients with gastric cancer are unknown. Here, we investigated the correlations of the expression levels of DAL-1 and TOB1 with the progression of gastric cancer.MethodsA total of 270 patients who underwent resectable gastrectomy were included. The expression of DAL-1 and TOB1 was detected by immunohistochemistry.ResultsLow expression of DAL-1 in cancer tissue was significantly associated with tumor site (p < 0.05), histological grade (p < 0.01), depth of invasion (p < 0.05), lymph node metastasis status (p < 0.05), Lauren classification (p < 0.001), and clinical stage (p < 0.01). A lower level of TOB1 was observed in gastric cancer patients with diffuse type disease compared to patients with either intestinal or mixed type disease (p < 0.001). Additionally, Spearman’s correlation analysis revealed that decreased expression of DAL-1 was positively correlated with low TOB1 expression (r=0.304, p < 0.001). The survival analysis showed that low levels of DAL-1 and TOB1 were significantly associated with poor survival of gastric cancer patients (p <0.001 and p < 0.05, respectively).ConclusionThe downregulation of DAL-1 and TOB1 expression is associated with shorter survival of gastric cancer patients. Hence, DAL-1 and TOB1 may be considered potential novel markers for predicting the outcomes of patients with gastric cancer. 相似文献
14.
Keyang Qian Hanqing Qian Juan Cai Wuheng Yue Xiaoxiao Yu Baorui Liu 《Pathology, research and practice》2019,215(4):755-760
Gastric cancer, one of the most common disease, has become a major public health problem worldwide. Cisplatin (DDP) has been a widely used drug for the treatment of cancer, also usually applied in gastric cancer in clinic. However, the side effects including toxicity and drug-resistance restricted the usage of DDP in clinic, so we prepared a DDP-complexed hydrogel (DDP-Gel) and investigated its efficacy in gastric cancer. For in vivo studies, MKN45-Luc cells were injected into BLAB/C node mice subcutaneously to establish gastric cancer with orthotopically grown tumors. Mice bearing tumors were treated with normal saline, DDP and DDP-Gel. Body weight and survival condition were observed and recorded. The treatment efficacy in vivo was detected by luciferase imaging and histological evaluation was performed by H&E staining of different organs. Additionally, normal ICR mice were treated with different doses of DDP/DDP-Gel to calculate their LD50 in vivo. The results showed that DDP-Gel prolonged survival time and ameliorated body weight changes of mice bearing tumors. DDP-Gel exhibited higher efficacy to inhibit tumor growth and metastasis, compared to DDP. Besides, LD50 of DDP-Gel was 166.0?mg/kg, 13.2 folds higher than DDP. As a conclusion, DDP-Gel showed a more effective and safer function than DDP in gastric cancer, which indicating that DDP-Gel might be a novel strategy for gastric cancer therapy. 相似文献
15.
16.
17.
BackgroundPre-operative carbohydrate (CHO) drinks have shown some benefits peri-operatively and have been incorporated into many Enhanced Recovery after Surgery (ERAS) programmes. We assessed the gastric emptying of pre-operative CHO drinks prior to elective caesarean delivery using ultrasonography.MethodsAfter a standard overnight fast, non-labouring pregnant women awaiting elective caesarean delivery underwent a standardised gastric ultrasound assessment at baseline and then every 20 min for 2 h after consuming 400 mL of a CHO drink. The gastric emptying was determined at each time-point both qualitatively and quantitatively. The primary outcome was the time taken for participants to return to a qualitative fasted Perlas grade of 0 or 1.ResultsThe gastric emptying of 40 participants was analysed. At baseline, all patients had a qualitative grade of either 0 or 1. All patients had returned to either grade 0 or 1 by 100 min. At 120 min the antral right lateral decubitus (RLD) cross-sectional area (CSA) was 8.03 cm2 (95th percentile; 95% CI 7.4 to 8.3 cm2) and gastric volume per kg was 1.57 mL/kg (95th percentile; 95% CI 1.4 to 2.2). At 120 min there was no statistically significant difference from baseline for the RLD CSA (P=0.38) or gastric volume per kg (P=0.27).ConclusionsThe gastric emptying of this cohort of pregnant women suggests that 400 mL of a CHO drink can be safely consumed up to two hours before elective surgery. This study can help inform future peri-operative fasting guidelines for pregnant patients. 相似文献
18.
19.
20.