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51.
《孙文垣医案》又名《生生子医案》、《赤水玄珠医案》,系由明著名新安医家孙一奎之子及门人等将其治验按先后顺序汇编而成。全书五卷共载三百九十八案,其中孙一奎运用二陈汤治验达四十余案。二陈汤以燥湿化痰为宗旨,孙一奎灵活运用于各种疾病,治多奇效,异曲同工。 相似文献
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Marziyeh Mazaheri Moghaddam Madiheh Mazaheri Moghaddam Hamid Hamzeiy Amir Baghbanzadeh Fariba Pashazadeh Ebrahim Sakhinia 《Journal of assisted reproduction and genetics》2021,38(3):573
PurposeAcephalic spermatozoa syndrome (ASS) is known as a severe type of teratozoospermia, defined as semen composed of mostly headless spermatozoa that affect male fertility. In this regard, this systematic review aimed to discuss gene variants associated with acephalic spermatozoa phenotype as well as the clinical outcomes of intracytoplasmic sperm injection (ICSI) treatment for the acephalic spermatozoa-associated male infertility.MethodsA systematic search was performed on PubMed, Embase, Scopus, and Ovid databases until May 17, 2020. This systematic scoping review was reported in terms of the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) statement.ResultsTwenty articles were included in this systematic review. Whole-exome and Sanger sequencing have helped in the identification of variants in SUN5, PMFBP1, BRDT, TSGA10, DNAH6, HOOK1, and CEP112 genes as possible causes of this phenotype in humans. The results of the ICSI are conflicting due to both positive and negative reports of ICSI outcomes.ConclusionASS has a genetic origin, and several genetic alterations related to the pathogenesis of this anomaly have been recently identified. Notably, only SUN5 and PMFBP1 mutations are well-known to be implicated in ASS. Accordingly, more functional studies are needed to confirm the pathogenicity of other variants. ICSI could provide a promising treatment for acephalic spermatozoa-associated male infertility. Besides the importance of sperm head-tail junction integrity, some other factors, whether within the sperm cell or female factors, may be involved in the ICSI outcome.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10815-020-02008-w. 相似文献
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孙思邈是我国唐朝著名的医学家,《千金要方》《千金翼方》为其代表作,书中不仅载有各科疾病处方,亦记载了大量针灸学内容,其主要针灸学术特点反映于这两部书籍之中,为针灸学的发展作出了突出贡献。本文主要从经穴理论发挥、针灸治未病、灸有生熟说、针药结合及针脉结合、完善刺灸法、辑录针灸处方、擅用外治法七个方面来阐述孙思邈之针灸学术特点。 相似文献
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慢性鼻-鼻窦炎是耳鼻喉科常见病、多发病。孙海波教授认为本病为“气失宣和、窍道闭阻”所致,临证重视局部四诊辨证,治以“升清荡浊、调肝理脾、宣通肺气”之法。 相似文献
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Keitaro Hashimoto Masaaki Ishii Sadayoshi Komori Harumi Mitsuhashi 《Heart and vessels》1985,1(1):29-35
Summary Antiarrhythmic effects of three new drugs, propafenone, tocainide, and SUN 1165, were examined using three canine ventricular arrhythmia models, i.e., digitalis, adrenaline and two-stage coronary ligation arrhythmias. The effects of procainamide, disopyramide, lidocaine, and phenytoin, class 1 antiarrhythmic drugs, on digitalis arrhythmia were also examined. The minimum effective plasma concentrations of all these drugs for each arrhythmia model were determined for a quantitative comparison. Propafenone and tocainide suppressed all the arrhythmias, while SUN 1165 suppressed digitalis and coronary ligation arrhythmias. The minimum effective plasma concentrations of propafenone for digitalis, adrenaline, 24-h coronary ligation, and 48-h coronary ligation arrhythmias were 1.8±0.7, 0.58±0.20, 3.5±0.3, and 3.6±0.9 µg/ml, respectively, and those of tocainide were 6.2±2.1, 23.7±9.0, 11.4±0.5, and 8.6±2.9 µg/ml, respectively (mean±standard deviation,n=6–7). The minimum effective concentrations of SUN 1165 for digitalis, 24-h coronary ligation, and 48-h coronary ligation arrhythmias were 0.92±0.19, 2.5±0.4, and 1.2±0.4 µg/ml. The minimum effective concentrations for digitalis arrhythmias were 1.7±0.4 µg/ml for disopyramide, 10.1±2.4 µg/ml for procainamide, 3.5±1.6 µg/ml for lidocaine, and 11.3±3.0 µg/ml for phenytoin. Digitalis arrhythmia seems to be a useful model for detecting class 1 drugs, as it was suppressed by all the class 1 Na-channel blocking antiarrhythmic drugs, while class 2 beta adrenergic blockers and class 4 Ca-channel blockers had no effect. Also, not all the class 1 drugs suppressed coronary ligation and adrenaline arrhythmias. 相似文献
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