构建医疗机构调剂审方思维

目的:构建医疗机构调剂审方思维。方法:结合门诊药房调剂工作实例,概括药师构建药品通用名、药品规格和用量、治疗方案、药品不良反应、药物组成等方面的审方思维。结果与结论:药师构建审方思维对确保临床安全、合理用药非常必要,有益于在医院药学工作转型和药师观念与职能转变方面发挥作用。     

浅谈GB／T14233．1-1998环氧乙烷残留量计算公式中的问题

本文围绕环氧乙烷残留量计算过程中遇到的问题，探讨相应的方法，使环氧乙烷残留量的计算过程进一步科学化。此建议已被全国医用输液器具标准化技术委员会采纳。     

中药灌肠治疗盆腔炎102例

中药灌肠治疗盆腔炎１０２例王肖凤，蒋俭自１９８４年以来，我们采用中药灌肠法治疗盆腔炎患者１０２例，获得了较好疗效。临氏资料１０２例均参照《实用妇科学》（山东：山东人民出版社，１９７５：１８０）盆腔炎的诊断标准诊断。１０２例除３例未婚外，均为已婚。年龄...     

Sobh Formula: A New Formula for Estimation of Creatinine Clearance in Healthy Subjects and Patients with Chronic Renal disease

Backgrounds: Cockcroft–Gault formula overestimates creatinine clearance (Ccr) in obese or edematous patients. This limitation urged us to develop a new formula that can overcome the limitation of Cockcroft–Gault formula. Methods: We developed a new formula suitable for rapid bedside estimation of creatinine clearance in healthy adults and elderly persons and patients with chronic renal disease considering the surface area as a reliable factor for estimation of creatinine clearance. This cross sectional study included 182 individuals (healthy persons and patients with chronic kidney disease). Ccr was estimated by different methods including 24 hours urine collection, Cockcroft–Gault equation, and our new formula, and ^99mTc-DTPA isotope clearance which was considered as a standard method for comparison between the other methods.Results: Our new formula had a statistically significant higher correlation coefficient with the standard ^99mTc-DTPA isotope clearance for all groups included in this study (r=0.97) than either Cockcroft–Gault formula (r=0.90) or 24 hours urine collection method (r=0.88). Conclusion: Our formula is a step forward for a better bedside assessment of kidney function in both healthy individuals and patients with chronic kidney disease.     

Increased kidney growth in formula-fed versus breast-fed healthy infants

A high protein intake results in increased kidney growth and glomerular filtration rate in human adults and young rats. It is unknown whether kidney size in young infants is influenced by increased protein intake in formula-fed compared with breast-fed infants. We investigated the effect of formula versus breast feeding on kidney growth in a cohort of 631 healthy children examined at birth, and at 3 and 18 months of age. Kidney size was determined by ultrasonography and related to gender, age, body size, and feeding category (fully breast fed, partially breast fed, or fully formula fed at 3 months). Serum urea nitrogen, serum creatinine, and estimated creatinine clearance were measured at 3 months of age. Kidney growth and serum urea nitrogen were significantly increased in partially or fully formula-fed 3-month-old infants. This effect was more pronounced in boys than in girls. The changes in relative kidney size were temporary, as they did not persist at 18 months of age, when all children received a normal mixed diet. The immediate renal effects of formula feeding should be taken into consideration for recommendations concerning infant feeding. Whether there are any long-term effects of early increased protein intake on later kidney function remains to be seen.     

Importance of insulin content in infant diet: suggestion for a new infant formula

Oral insulin promotes intestinal maturation and may prevent diabetes in animal models. The aim of this study was to evaluate the concentration of insulin in human milk and in different infant formulas. Our results show that the concentration of insulin in human milk is significantly higher (60.23 +/- 41.05 microU/ml mean +/- SD) compared with cow's milk (16.32 +/- 5.98 microU/ml mean +/- SD) and that insulin is hardly detectable in infant formulas. We propose the addition of human insulin to infant formula to match its composition more closely to human milk.     

扶正固本颗粒配合放射治疗中晚期食管癌临床疗效观察

目的:观察扶正固本颗粒配合放射治疗中晚期食管癌的疗效。方法:将232例中晚期食管癌随机分为扶正固本颗粒加放疗组与单纯放疗组,两组均行常规分割放疗,1.8~2.0Gy/d,总量50~70Gy/5~8周。扶正固本颗粒加放疗组在行放疗的同时,给予扶正固本颗粒口服,15g/次,3次/日,50~55天为一疗程。结果:单纯放疗组1、3、5年生存率分别为41.4、14.7、7.6,扶正固本颗粒加放疗组1、3、5年生存率分别为63.8、29.3、19.0。1、3、5年生存率扶正固本颗粒加放疗组明显优于单纯放疗组(P<0.05)。结论:扶正固本颗粒配合放疗可增加近期疗效与提高远期生存率,同时可减轻骨髓抑制等放射副反应。     

固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌的临床研究

目的观察固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌的疗效。方法78例晚期大肠癌患者随机分成治疗组(38例)、对照组(40例)。78例晚期大肠癌患者接受OXA85mg/m2静脉点滴2h,d1;CF200mg/m2静脉点滴2h,5-FU400mg/m2静脉推注后续以600mg/m2持续静脉点滴22h,d1-2;2周重复,为1周期。治疗组同时口服固本消瘤胶囊。应用4周期后判定疗效。结果治疗组与对照组的临床受益率(CR PR SD)分别为76.3%、57.5%(P<0.05)。固本消瘤胶囊联合FOLFOX4方案能提高患者的细胞免疫功能,缓解化疗药物的毒副反应,改善患者的生活质量。结论固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌有较好的近期疗效。     

基于网络药理学和分子对接探讨预防肺疾一号方预防新型冠状病毒肺炎（COVID-19）的作用机制＊

目的 从分子层面探讨预防肺疾一号方预防新型冠状病毒肺炎的作用机制，并探索预防肺疾一号方的潜在治疗靶点。方法 利用TCMSP数据库及BATMAN-TCM数据库筛选预防肺疾一号方的化合物成分，在PharmMapper数据库进行潜在靶点识别，然后使用David软件对靶点进行GO富集及KEGG通路富集分析，利用iGEMDOCK软件进行分子对接分析。结果 通过网络药理学方法分析预防肺疾一号方的6味中药，发现其有效化学成分有58个，对应47个作用靶点；通过GO分析靶点富集出81个生物学过程、26个细胞组成及31个分子功能；通过KEGG分析得出靶点显著富集的信号通路有35条；分子对接分析得出，靶点CAT和化合物Daidzein-4，7-diglucoside的结合度最高。结论 预防肺疾一号方具有多成分、多靶点的作用特点，并通过参与多种生物过程，调控多条信号通路以预防新型冠状病毒肺炎并发挥其药理疗效。     

小儿七珍丸治疗小儿乳食积滞、痰火互结证404例

目的 评价小儿七珍丸对小儿乳食积滞、痰火互结证的临床疗效和安全性.方法 采用随机、单盲、阳性药物平行对照、多中心临床研究的方法进行,观察试验组患儿302例,对照组102例.试验组服用小儿七珍丸,对照组服用健儿药丸.疗程定为1 d,晨起空腹服药一次,服药24 h后对疗效与安全性指标进行评价.结果 试验组痊愈率33.77%,总有效率94.04%;对照组痊愈率27.45%,总有效率89.22%,两组比较,无统计学意义（P＞0.05）.试验组与对照组各中医症状比较无统计学差异（P＞0.05）.试验组年龄、病程、病情与疗效无关（P＞0.05）.未见明显不良反应.结论 小儿七珍丸治疗小儿乳食积滞、痰火互结症疗效确切,临床使用安全.