苏子油对大鼠血脂及血液流变性的影响

报告了苏子油对大鼠血清甘油三脂（ＴＧ）、总胆固醇（ＴＣ）、高密度脂蛋白（ＨＤＬ－Ｃ）、低密度脂蛋白（ＬＤＬ－Ｃ）、红细胞变形指数、血小板聚集率及ＨＤＬ－Ｃ／ＴＣ的影响。实验共分三组，猪油组、苏子油组、基础饲料组，前二组均为高脂饲料。试验期７８天。结果显示：苏子油组血ＴＣ值在试验后３０天即显著低于猪油组（Ｐ＜０．０５）。试验期末，苏子油组的ＴＣ、ＴＧ、ＬＤＬ－Ｃ均显著低于猪油组（Ｐ＜０．０５），ＴＧ值还低于基础饲料组（Ｐ＜０．０５），而ＨＤＬ－Ｃ／ＴＣ则显著高于猪油组；ＨＤＬ－Ｃ三组差别不明显（Ｐ＞０．０５）；血小板聚集率基础饲料组和苏子油组差别无意义（Ｐ＞０．０５）；但红细胞变形指数以基础饲料组最低，苏子油组其次，猪油组最高，后两组差别无意义（Ｐ＞０．０５）。提示富含α－亚麻酸的苏子油具有良好的预防和降低血脂的作用，值得进一步研究和开发。     

Relationship between expression of CD40-CD40 ligand system and serum cholesterol levels in patients with hypercholesterolemia

Hypercholesterolemia is associated with the pathogenesis of atherosclerosis. Enhanced levels of thrombin, fibrinogen and factor Ⅶc directly correlate with cholesterol levels.1 Activated platelets adhere to the intact endothelium and induce inflammatory responses in the endothelium, which substantially contribute to the early phase of atherosclerosis. Emerging lines of evidence support the role of CD40-CD40L interactions in atherosclerosis, thrombosis and inflammation.2 In atherosclerosis, inhibition of the CD40-CD40L interaction in LDL receptors or ApoE-deficient mice prevents the initiation of atherosclerosis and the evolvement of established atherosclerotic lesions to more advanced lesions.     

九连山自然保护区冬青属植物资源的初步研究

通过对九连山自然保护区冬青属植物资源的调查研究，发现保护区内共有34种(包括变种)冬青属植物，其中8种为江西新分布，其垂直分布范围较广，以海拔800m以下最为集中。与邻近山体冬青属植物比较结果表明谈属内不同种的数量存在差异。     

基于非标准协议无线通信的个人健康监护系统设计

基于非标准协议的短距离无线通信，具有成本低、易开发、低功耗的优点，非常适用于小范围内的数据传输。提出一种基于非标准无线通信芯片nRF24L01的个人健康监护系统设计方案，并将其与现有的、基于标准协议无线通信的个人健康监护系统进行比较。结果表明：基于非标准协议无线通信的个人健康监护系统具有效率高、功耗低、通信性能好的特点。     

Pharmacological properties of a lyophilizate from Galeopsis ladanum on the central nervous system of rodents

The influence of a fraction obtained from Galeopsis ladanum L. on the central nervous system of rodents was examined. The results of these investigations show that the fraction impeded CNS activity. It is practically nontoxic and at a dose of 2000 mg/kg i.p. it does not have a soporific influence on mice. It reduces considerably the spontaneous locomotor activity of mice as well as the locomotor activity of mice stimulated by caffeine, but did not influence the locomotor activity induced by amphetamine. The extract did not exhibit a synergetic effect with barbiturates. The results suggest that the pharmacological activity of the extract resembled the activity of drugs which generally depress the CNS, being on the border between ataractic and sedative drugs.     

民族药香青兰化学成分及药理作用研究进展

摘要：目的：对民族药香青兰进行化学成分及药理活性的研究,对该药材的综合应用和深入研究奠定基础。方法：通过查阅1995-2022年知网、PubMed中的中英文文献与相关文献对香青兰进行综述。结果：经过系统的研究,发现香青兰的组成主要包含总黄酮和黄酮苷类、挥发油、三萜类和蛋白质等。这些成分有着多种药理作用,如抗缺氧、抗血栓和降血压。结论：香青兰对于治疗高血压,心脏病等有一定疗效。香青兰在蒙医临床中应用广泛。研究表明,香青兰的化学成分和药理作用已经取得了一定的进展,其作用范围广泛,对心血管疾病有显著的疗效。     

GREB1L基因突变致后天性单侧肾萎缩一例报道并文献复习

肾发育不良和肾发育不全（RAH）是先天性肾脏与尿路畸形（CAKUT）的主要表现之一,是导致儿童慢性肾脏病的重要原因。遗传因素与发病密切相关,随着全基因检测技术的发展,越来越多与RAH相关的基因突变被报道,GREB1L基因突变已被证实可导致RAH。本研究报道了1例后天性单侧肾萎缩GREB1L基因c.4688A>G杂合突变患儿,并复习相关文献。该患儿基因突变源自母亲,该变异为罕见变异,并且具有不完全外显特性,多种蛋白质危害预测软件预测该突变为有害变异。本文发现了新的GREB1L基因突变位点,可能拓展了与RAH相关的基因突变谱和临床谱。     

依达拉奉联合瑞舒伐他汀治疗心源性脑梗死的疗效及对血清CXCL12、UCH-L1、HC-gp39水平的影响

目的 探究依达拉奉联合瑞舒伐他汀治疗心源性脑梗死的疗效及对血清趋化因子12（CXCL12）、泛素C末端水解酶L1（UCH-L1）、人类软骨糖蛋白-39（HC-gp39）水平的影响。方法 选取2020年3月—2022年4月达州市中心医院收治的90例心源性脑梗死患者作为研究对象,随机分为对照组和观察组,各45例。对照组给予瑞舒伐他汀治疗,观察组给予依达拉奉联合瑞舒伐他汀治疗。比较两组疗效、CXCL12、UCH-L1、HC-gp39、血液流变学指标、血脂水平及美国国立卫生研究院脑卒中量表（NIHSS）评分。结果 观察组总有效率高于对照组（P <0.05）。观察组治疗前后血清CXCL12、UCH-L1、HC-gp39水平的差值高于对照组（P <0.05）。观察组治疗前后全血低切黏度、全血高切黏度及纤维蛋白原水平的差值高于对照组（P <0.05）。观察组治疗前后TC、TG、LDL-C水平的差值高于对照组（P <0.05）。观察组治疗前后NIHSS评分的差值高于对照组（P <0.05）。结论 依达拉奉联合瑞舒伐他汀治疗心源性心肌梗死可有效提高患者临床疗效,改善血液流变学指标、血脂、神经功能及炎症反应。     

Allergic bronchopulmonary aspergillosis: Reactivity of IgE and IgG antibodies with antigenic components of Aspergillus fumigatus (IgE/IgG antigen complexes)

Sera of patients with ABPA were tested by XRIE tests incorporating their own serum (self-XRIE) to detect the presence of IgG/IgE antigen complexes to a “reference” Aspergillus fumigatus preparation. Of the 32 sera studied, 29 (90%) had visible precipitin (IgG) peaks, and 27 of these 29 as well as the three apparently precipitin-negative sera, i.e., 30 (94%), showed binding of specific IgE by autoradiography. The two precipitin-positive sera that did not show IgE binding were also skin test negative and RAST negative to this A. fumigatus antigen. Specific IgG as determined in ELISA correlated well with the grading of the XIE precipitin peaks (p < 0.05). There was also a highly significant correlation between specific IgE by RAST and grading the radioactive uptake seen in the autoradiograph (p < 0.001) indicating, for each serum, the presence of IgG antibodies to most of the components to which there was specific IgE. In the self-XRIE tests there was considerable variation of reactivity from serum to serum, in numbers of antigen/antibody peaks observed, in relative peak heights, and in the intensity of the respective staining. By comparing each test to a “reference” pattern developed with the use of an ABPA serum pool, the antigenic components of A. fumigatus were found to be of two main types: (1) antigens that appeared to be poorly precipitating (possibly low-molecular-weight components) but showed strong IgE binding (these were apparently major allergenic components and with one exception proved to be the faster migrating components) and (2) antigens that produced the strongest precipitin reactions with only weak binding of specific IgE and therefore minor allergenic components.     

L-选择蛋白在小鼠肝癌细胞高低转移株HCa-F、HCa-P的表达及与肿瘤转移潜能的相关性

目的　探讨经淋巴道转移的小鼠肝癌细胞高低转移株HCa F、HCa P淋巴道转移能力及与淋巴细胞归巢受体L 选择蛋白的相关性。方法　应用免疫印迹分析、RT PCR及流式细胞术检测小鼠肝癌HCa F、HCa P细胞表面L 选择蛋白的表达情况 ,再通过E 、P 、L 选择蛋白的抗体对细胞粘附实验的影响检测HCa F、HCa P细胞淋巴道转移潜能与L 选择蛋白的相关性。结果　L 选择蛋白在HCa F、HCa P细胞表面均有表达 ,且HCa F细胞的表达量明显高于HCa P细胞 (P <0 .0 1) ,HCa F细胞与淋巴结之间的粘附可被抗L 选择蛋白的抗体所阻断。结论　小鼠肝癌细胞高低转移株HCa F、HCa P细胞均表达L 选择蛋白 ,其程度与该细胞的淋巴道转移潜能正相关