针刺对糖尿病视网膜病变免疫调节机理的研究

目的：探讨针刺治疗糖尿病视网膜病变的机理,并加以论证,为其临床应用提供理论依据。方法：选择大鼠建立糖尿病视网膜病变动物模型,分别以针刺治疗及胰岛素治疗,并设正常对照组及模型对照组,于３个月及６个月取大鼠血清及视网膜检测ＩＬ－２和ＴＮＦ及电镜检察。结果：各时段ＩＬ－２针刺及胰岛素治疗组明显高于模型对照组：ＴＮＦ明显氏于模型对照组。两与正常对照组无显性差异,针刺后电镜观察视网膜微血管病变得到改善。     

The diagnostic accuracy of rapid diagnostic tests for Ebola virus disease: a systematic review

BackgroundEbola virus disease (EVD) is a dangerous condition that can cause an epidemic. Several rapid diagnostic tests (RDTs) have been developed to diagnose EVD. These RDTs promise to be quicker and easier to use than the current reference standard diagnostic test, PCR.ObjectivesTo assess the diagnostic accuracy of RDTs for EVD.MethodsA systematic review of diagnostic accuracy studies.Data sourcesThe following bibliographic databases were searched from inception to present: MEDLINE (Ovid), Embase, Global Health, Cochrane Central Register of Controlled Trials, WHO Global Index Medicus database, Web of Science, PROSPERO register of Systematic Reviews, and Clinical Trials.Gov.Study eligibility criteriaDiagnostic accuracy studies.ParticipantsPatients presenting to the Ebola treatment units with symptoms of EVD.InterventionsRDTs; reference standard, RT-PCR.Assessment of risk of biasQuality Assessment of Diagnostic Accuracy Studies-2 tool.Methods of data synthesisSummary estimates of diagnostic accuracy study were produced for each device type. Subgroup analyses were performed for RDT type and specimen material. A sensitivity analysis was performed to assess the effect of trial design and bias.ResultsWe included 15 diagnostic accuracy studies. The summary estimate of sensitivity for lateral flow assays was 86.1% (95% CI, 86–86.2%), with specificity of 97% (95% CI, 96.1–97.9%). The summary estimate for rapid PCR devices was sensitivity of 96.2% (95% CI, 95.3–97.9%), with a specificity of 96.8% (95% CI, 95.3–97.9%). Pre-specified subgroup analyses demonstrated that RDTs were effective on a range of specimen material. Overall, the risk of bias throughout the included studies was low, but it was high in patient selection and uncertain in the flow and timing domains.ConclusionsRDTs possess both high sensitivity and specificity compared with RT-PCR among symptomatic patients presenting to the Ebola treatment units. Our findings support the use of RDTs as a ‘rule in’ test to expedite treatment and vaccination.     

FUNCTIONAL MAPPING OF THE HUMAN BRAIN DURING ACUPUNCTURE WITH MAGNETIC RESONANCE IMAGING SOMATOSENSORY CORTEX ACTIVATION

1NTRODUCTIONHegu(Ll4)isoneofthemosteffectiveandmostfrequentlyusedacupointsintraditionalChineseacupuncture.ItisindicatedfOrpaininmanypartsofthebody,butisparticularlyeffec-tiveforheadache,migraine,toothache,sorethroatandotherd1sordersoftheheadandface.Manyanimalexperimentsindicatethathighercentersinthenervoussystemareinvolvedinacupunctureanalgesia["2]butdirectevidenceforhumansubjectsisdifficulttoobtainuntilthere-centadventofpowerfu1andn0n-invasivemeth-odsforneuroimaginginthe9O's.Werecentlya…     

HOW TO TREAT OPTIC ATROPHY WITH ACUPUNCTURE ?

Opticatrophyresultsfromretrogradede-generationofopticnerve,causingtheopticdisctobecomepaleandappearshallowconcave.Itissimilarto"qingmang(opticatrophy)","shizhanhunmiao(blurredvirsion)"describedintraditionalChinesemedicine,manifestingmainlyasthatthediseasedeyeisnormalinappearance,butthepatientfeelsdiminutionofvirsion,blur-ringofvirsion,etc..Thesesituationsbecomeworseandworsedaybyday.Fundusexamina-tionshQWsthattheopticpapillalightensincolourorevengetspale,andbloodvesselsofretinaarenormalorbecom…     

PRELIMINARY RESEARCH ON ACUPUNCTURE EFFECTS IN IMMUNOLOGY

Experimental research has recently shown that acupuncture induces the formation of o-pioid-like peptides in animals.The role ofβ-endorphin in the mechanism of acupuncture is discussed:some authors maintain the hormonal hypothesis,others the role of neurotransmltters and,up to thepresent,no convincing evidence for either hypothesis has been demonstrated.In order to provide fur-ther evidence,we tested the β-endorphin levels and other parameters（VLP,lymphocyte subsets,NKcells and phagocyte activity of monocytes）in a group of 90 patients suffering from various painful dis-orders treated with acupuncture.Zusanli（ST 36）and Hegu（LI 4）acupoints were selected.A homo-geneous group of 30 subjects was used as control.Evaluation of the above parameters was made with3 series of blood tests;before treatment,30 minutes and 24 hours after acupuncture treatment.In theacupuncture group,the following results were achieved: a）A considerable increase in β-endorphin levels,which remained high even 24 hours afteracup     

PROGRESS AND PERSPECTIVE OF ACUPUNCTURE AND MOXIBUSTION IN DELAYING SENILITY

In this paper, we reviewed the developing history of delaying senility of acupunctureand moxibustion, summarized 41 reports about the effects of acupuncture and moxibustion on elderly,normal subject and the "deficiency syndrome" model animal, and expounded the rnechanisms in the aspects of immunology, endocrinology and biology. In addition, we also discussed the influence fac-tors and the developing trends of delaying senility of acupuncture and moxibustion in corning years.     

舌下针治疗中风(缺血性)的疗效及血液流变学变化的观察

：以舌下针对70例中风（缺血性）患者进行针刺治疗,观察到针刺后患者的全血比粘度（包括全血还原比粘度）、红细胞压积、血沉、红细胞电泳时间以及血浆比粘度等指标均有降低,其差异经统计学处理有非常显著意义（P＜0.01）,可见用舌下针针刺后．患者血液的浓稠性、凝固性、粘滞性、聚集性均较针刺前有显著改善,这表明针刺后能使血液粘度降低、血管阻力减弱、血液流动加快、血流量增加．从而改善了中风（缺血性）患者的脑部的血循环,这对患者的治疗无疑是大有裨益的。     

针刺关元穴对小鼠红细胞免疫功能影响的实验研究

目的：探讨针刺关元穴对机体红细胞免疫的影响。方法：将小鼠随机分为对照组和针刺组,针刺组每日针刺关元穴,对照组不予针刺。１１ 日后采用补体致敏酵母菌血凝法,并分别测定各组小鼠的脾脏系数,检测针刺关元穴对小鼠红细胞免疫粘附功能的影响。结果：在血凝滴度为１：１６ 时,对照组与针刺组小鼠的阳性率有显著性差异（Ｐ＜ ０．０１）;脾脏系数分别为：对照组（５．７９±０．８８ｍ ｇ／ｇ）,针刺组（６．０８±０．３４）ｍ ｇ／ｇ。针刺组明显高于对照组（Ｐ＜ ０．０５）。结论：针刺关元穴对小鼠的红细胞免疫粘附功能有增强作用。     

神阙穴贴药对原发性骨质疏松症超声穿透速度的影响

目的：观察神阙穴贴补血益精透皮贴剂，对原发性骨质疏松症超声穿透速度（SOS）的影响。方法：选择原发性骨质疏松症患者130例。分4组治疗。即补血益精透皮贴剂组（A组），西药对照组（B组），补血益精药丸组（C组），空白对照组（D组）。结果：补血益精透皮贴剂组能显著提高超声穿透速度。结论：补血益精透皮贴剂组与补血益精药丸组和西药对照组对原发性骨质疏松症的调整作用基本一致。为治疗原发性骨质疏松症提供了一种新的方法。     

面口合谷收的形态学基础

目的：探讨合谷穴与口面部联系的形态学基础。方法：采用荧光素单标记和双标记法，将荧光素碘化丙啶（PI）和双苯甲亚胺（Bb)分别注入“合谷”穴区和“四白”穴区，取同侧脊神经节颈1-颈8，胸1-胸2，颈上，中，下交感节及三叉神经半月节，荧光显微镜下观察计数。结果：在脊神经节颈5-颈8观察到大量PI单标记细胞，主要分布于颈6-颈7，在三叉神经半月节也可见大量Bb单标记细胞，另外在三叉神经半月节可见少量PI-Bb以标记细胞，占标记细胞的4.5%。结论：三叉神经半月节有向“合谷”穴和“四白”穴的分支投射，这可能是“面口合谷收”的形态学基础。