脂多糖刺激对miR-155调节B淋巴细胞肿瘤样变的影响

目的研究脂多糖刺激后对微小RNA（miR-155）诱导B淋巴细胞肿瘤样变的影响。方法实时定量聚合酶链式反应（qRT-PCR）检测脂多糖刺激后0 h、4 h、12 h、24 h、48 h B淋巴母细胞中miR-155的表达量,同时检测转录因子PU1mRNA和蛋白水平的表达,流式细胞技术检测B细胞表面分子CD10表达变化。结果脂多糖刺激B淋巴细胞后,随着时间的增加,miR-155表达呈递增趋势,增至正常水平3.6倍,刺激前后B淋巴母细胞miR-155表达差异有统计学意义（t=6.76,P＜0.05）。而转录因子PU1表达水平呈降低趋势,刺激前后B淋巴母细胞PU1表达差异有统计学意义（t=4.22,P＜0.05）。脂多糖刺激B淋巴细胞24 h后CD10数量由（32.10±2.82）%上升到（80.60±3.14）%,差异有统计学意义（t=2.13,P＜0.05）,B淋巴细胞增殖能力增强,细胞克隆数增加近4倍,差异有统计学意义（t=2.56,P＜0.05）。结论 miR-155通过转录因子PU1间接调控CD10分子的表达,诱导B细胞的肿瘤样变,推断miR-155在B淋巴细胞的成瘤过程中发挥重要作用。     

“Secondary stacking” as a shaping option in former breast augmentation with polyurethane coated implants

“Stacking”– the insertion of several polyurethane (PU) coated prostheses in breast augmentation as propagated by Hester et al. [3] – often proves to be an interesting option in problem situations in cosmetic breast surgery. Caution is advised, however, in correcting augmentation surgery. The original PU-coated implant should not be removed since this can cause complications. All further implants should be placed in a “virgin” submuscular pocket. Received: 23 June 1997 / Accepted: 13 January 1998     

胃底、胃体、胃窦部溃疡病人胃窦部MMC Ⅲ期的累积动力指数的测定及意义

目的　为了明确胃底、胃体及胃窦部溃疡病人在消化间期移行性复合运动Ⅲ期 (MMCⅢ )的累积动力指数 (CMI)与健康人的关系。方法　对健康人 (HC)、胃底溃疡病人 (FU)、胃体溃疡病人 (CU)、胃窦部溃疡病人 (PU)各30例进行 4小时胃内压力的测定并计算MMCⅢ期的CMI值。结果　FU组MMCⅢ值为 11.2 0± 2 .15 ;CU组为 12 .3± 6 .3;PC组为 19.6 3± 1.2 4 ;HC组为 2 3.3± 7.7。故与HC组、FC组比较有显著差异 ;与CU组有差异 ;与PU无差异。结论　FU、CU病人的MMCⅢ期的CMI值均低于HC ,且FU组与HC组的差别有显著意义。而PU组与HC组差判别无统计学意义     

消溃愈疡汤治疗消化性溃疡临床研究

目的:观察消溃愈疡汤治疗消化性溃疡的临床疗效。方法:将46例消化性溃疡患者随机分为治疗组和对照组,每组各23例。对照组给予常规西药治疗,治疗组在对照组的基础上给予消溃愈疡汤治疗。比较两组患者的临床疗效及幽门螺杆菌(Helicobacter pylori,Hp)清除率。结果:治疗组有效率为95.65%,对照组有效率为82.61%,两组患者临床疗效比较,差异有统计学意义(P0.05)。对照组Hp清除率为65.22%,治疗组Hp清除率为91.30%,两组患者Hp转阴率比较,差异有统计学意义(P0.05)。结论:消溃愈疡汤治疗消化性溃疡取得满意疗效,可明显改善患者的临床症状。     

Is laser speckle contrast analysis (LASCA) the new kid on the block in systemic sclerosis? A systematic literature review and pilot study to evaluate reliability of LASCA to measure peripheral blood perfusion in scleroderma patients

Objectives

A reliable tool to evaluate flow is paramount in systemic sclerosis (SSc). We describe herein on the one hand a systematic literature review on the reliability of laser speckle contrast analysis (LASCA) to measure the peripheral blood perfusion (PBP) in SSc and perform an additional pilot study, investigating the intra- and inter-rater reliability of LASCA.

Comparison of Laser Doppler Imaging (LDI) and clinical assessment in differentiating between superficial and deep partial thickness burn wounds

Purpose of presentation/study

To compare the accuracy of Laser Doppler Imaging (LDI) and clinical assessment in differentiating between superficial and deep partial thickness burns to decide whether early tangential excision and grafting or conservative management should be employed to optimize burn and patient management.

消化性溃疡复发相关因素分析及护理干预

目的 探讨消化性溃疡(Peptic Ulcer PU)复发的危险因素及护理干预措施.方法 回顾性分析我院近3年PU复发58例的临床资料.结果 除幽门螺杆菌(Hp)外,男性、40岁以下、服用药物(非甾体消炎药及肾上腺皮质激素等)、季节(1、4季度)、精神饮食失调、未维持用药、愈合质量(S1期)、吸烟饮酒时PU复发率高.结论 上述因素是PU复发的危险因素,可通过健康教育、有关护理、服药指导、心理护理减少PU复发,提高生活质量.