高选择性环氧化酶—2抑制剂的进展与评价

目的 :介绍高选择性环氧化酶 - 2抑制剂———昔布类药物进展 ,并评价其临床疗效 ,以供临床参考。方法 :查阅国内、外近期相关文献进行分析、评价。结果与结论 :昔布类高选择性环氧化酶 - 2抑制剂进展十分迅速 ,对环氧化酶 - 2的选择性高 ,在治疗骨关节炎和类风湿性关节炎、关节痛、术后疼痛和肿瘤上展现了良好的治疗前景     

补肾法治疗糖尿病神经源性膀胱的研究进展

糖尿病神经源性膀胱是糖尿病常见并发症之一。中医理论认为该病主要病位在肾脏,补肾法是治疗该病的主导方法。回顾了近年来运用补肾法治疗糖尿病神经源性膀胱的相关临床研究进展,分析依然存在的不足之处,展望未来的研究方向与重点。     

淋巴水肿治疗的研究进展

淋巴水肿是淋巴系统的一种慢性疾病。随着我国恶性肿瘤发病人数和发病率的增加,癌症治疗后的淋巴水肿已经成为继发性淋巴水肿的主要病因。正确、合理的治疗对淋巴水肿预后十分重要。近年来,淋巴领域的治疗进展给患者带来了新的希望。本文就淋巴水肿治疗的研究进展进行综述。     

分化好的胃肠胰神经内分泌瘤G3的诊治新进展

神经内分泌肿瘤属于少见肿瘤,发病率低,异质性强,可发生于全身多个器官.在中国,胃肠胰是神经内分泌肿瘤发病率最高的部位,自2017年世界卫生组织(World Health Organization,WHO)消化系统肿瘤病理学分类关于胃肠胰神经内分泌肿瘤提出分化好的神经内分泌瘤G3(neuroendocrine tumor...     

Investigating the Impact of the New York State Flavor Ban on e-Cigarette–Related Discussions on Twitter: Observational Study

BackgroundOn May 18, 2020, the New York State Department of Health implemented a statewide flavor ban to prohibit the sales of all flavored vapor products, except for tobacco or any other authorized flavor.ObjectiveThis study aims to investigate the discussion changes in e-cigarette–related tweets over time with the implementation of the New York State flavor ban.MethodsThrough the Twitter streaming application programming interface, 59,883 e-cigarette–related tweets were collected within the New York State from February 6, 2020, to May 17, 2020 (period 1, before the implementation of the flavor ban), May 18, 2020-June 30, 2020 (period 2, between the implementation of the flavor ban and the online sales ban), July 1, 2020-September 15, 2020 (period 3, the short term after the online sales ban), and September 16, 2020-November 30, 2020 (period 4, the long term after the online sales ban). Sentiment analysis and topic modeling were conducted to investigate the changes in public attitudes and discussions in e-cigarette–related tweets. The popularity of different e-cigarette flavor categories was compared before and after the implementation of the New York State flavor ban.ResultsOur results showed that the proportion of e-cigarette–related tweets with negative sentiment significantly decreased (4305/13,246, 32.5% vs 3855/14,455, 26.67%, P<.001), and tweets with positive sentiment significantly increased (5246/13,246, 39.6% vs 7038/14,455, 48.69%, P<.001) in period 4 compared to period 3. “Teens and nicotine products” was the most frequently discussed e-cigarette–related topic in the negative tweets. In contrast, “nicotine products and quitting” was more prevalent in positive tweets. The proportion of tweets mentioning mint and menthol flavors significantly increased right after the flavor ban and decreased to lower levels over time. The proportions of fruit and sweet flavors were most frequently mentioned in period 1, decreased in period 2, and dominated again in period 4.ConclusionsThe proportion of e-cigarette–related tweets with different attitudes and frequently discussed flavor categories changed over time after the implementation of the New York State ban of flavored vaping products. This change indicated a potential impact of the flavor ban on public discussions of flavored e-cigarettes.     

实验室信息管理系统的技术与应用进展

实验室信息管理系统(LIMS)自问世以来,在世界范围内取得了令人惊叹的技术进展和应用成就。该文从现代化实验室实施LIMS的意义,LIMS主要的技术发展阶段,目前国内LIMS的应用情况,分析测试性实验室在实施LIMS后预期达到的目标,以及当前LIMS项目实施中存在的问题和应用前景等方面进行综述。     

妇科恶性肿瘤的时辰化疗进展

目的介绍近年来适用于妇科恶性肿瘤化疗的药物涉及时辰方案设计的研究成果,方法通过搜集并整理近年来国内外时辰化疗的相关临床和临床前试验的相关文献结果与结论应用时辰化疗理论,改进妇科肿瘤患者化疗方案和给药时间,可以有效降低化疗药物的毒副作用,较常规治疗具有优势,但不同人群、不同种族间的时辰依赖性是否存在差异,有待于进一步研究、     

碘难治性分化型甲状腺癌的最新研究进展

近年来,作为最常见的恶性肿瘤之一,甲状腺癌的发病率曲线明显上升。分化型甲状腺癌经过手术、¹³¹I放疗及促甲状腺激素抑制等治疗后,大多数患者总体预后良好。但仍有少部分患者对放射性碘治疗不敏感且有1个或多个癌基因的突变,则成为病情进展快、死亡率高的碘难治性分化型甲状腺癌。应用上述的传统治疗手段难以取得满意疗效,本文综述了碘难治性分化型甲状腺癌的诊断及治疗进展,为尽早识别及早期进行靶向治疗等争取必要的时间。     

溃疡性结肠炎的中医药治疗进展

文章对近年来中医药治疗溃疡性结肠炎从病因病机、治疗方法,包括分型论治,以基础方加减,成药治疗及治则进行了文献综述,并对存在的问题及发展前景作了阐述。