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91.
A. Lukić-grlić A. Baće R. Lokar-Kolbas D. Loffler-badžek V. Draženović J. Božikov G. Mlinarić-galinović 《European journal of epidemiology》1999,15(4):359-363
This paper has analyzed respiratory syncytial virus lower respiratory tract infections in 201 hospitalized children. In children with wheezing, erythrocyte sedimentation rate (ESR) was significantly higher in those with pneumonia than with syndroma pertussis, while the white blood cell (WBC) count was significantly lower in patients with bronchitis than in those with bronchiolitis and syndroma pertussis. Bronchodilatators were applied in 75.6% and corticosteroids in 20% of patients. Ten patients were ventilated. Fatal disease outcome was observed in one infant. Twelve consecutive-year study of respiratory syncytial virus (RSV) infections showed that 27.3% of these diseases were bronchiolitis and pneumonia. 相似文献
92.
本试验旨在评价优立新序贯疗法治疗下呼吸道感染的临床疗效和安全性。西力欣作为对照。入选病例61例,其中试验组(优立新)31例,对照组(西力欣)30例。给药方法采用静脉注射随后口服给药的序贯疗法:静脉注射优立新3~12g/天,连续 3~7天,继之口服舒他西林375mg~750mg,每天2次,连续5~7天;静脉注射西力欣3~6g/天,继之口服新菌灵250g~500g,每天 2次,疗程相同。结果试验组和对照组的临床有效率分别为80.6%(25/31)和90%(27/30)。61例患者共分离出致病菌41株。治疗结束后两组的细菌清除率分别为 82.14%(23/28)和 69.23%(9/13),毒副作用反应发生率分别为 6.45%和3. 33%。上述结果经统计学处理无显著性差异。无病者因毒副作用而退出试验。 相似文献
93.
Y. Fukuda Yoshihisa Fukuta Raita Higashino Masayuki Ogishima Kenji Yoshida Hajime Tamaki Mineo Takei 《Naunyn-Schmiedeberg's archives of pharmacology》1999,359(6):433-438
The effects of Z-350, (S)-4-[3-(4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazine-1-yl]propoxy} benzoyl)indole-1-yl]butyric
acid hydrochloride, a newly synthesized compound possessing α1-adrenoceptor antagonistic and steroid 5α-reductase inhibitory actions, were studied in vitro. In functional experiments,
Z-350 shifted the concentration/response curve for the phenylephrine-induced contraction of rabbit prostate, urethra and aorta
to the right with pA2 values of 8.04, 7.57 and 7.13, respectively. The binding affinity of Z-350 for α1-adrenoceptors in rabbit prostate, urethra and aorta were estimated by the displacement of [3H]prazosin. The pK
i values for this action of Z-350 were 7.53, 7.95 and 7.62 for the prostate, urethra and aorta, respectively. α1-Adrenoceptor subtype selectivities were studied in the submaxillary gland (α1A) and liver (α1B) of rat. Z-350 inhibited the specific binding of [3H]prazosin to α1A and α1B-adrenoceptors with pK
i values of 7.82 and 7.29, respectively. Z-350 inhibited rat prostatic steroid 5α-reductase non-competitively with a pIC50 of 8.42. These results indicate that Z-350 is a α1-adrenoceptor antagonist and is a steroid 5α-reductase inhibitor. It is expected that Z-350 will be a candidate drug for the
treatment of benign prostatic hyperplasia.
Received: 26 January 1999 / Accepted: 2 March 1999 相似文献
94.
The purpose of this study was to examine whether cardiorespiratory responses to combined rhythmic exercise (60 contractions · min–1) was affected by different combinations of upper and lower limb exercise in seven healthy women. Six different rhythmic exercises were compared: 6-min rhythmic handgrip at 10% of isometric maximal voluntary contraction (MVC) (H10); 6-min rhythmic plantar flexion at 10% MVC (P10); exhausting rhythmic handgrip at 50% MVC (H50); exhausting rhythmic plantar flexion at 50% MVC (P50); H50 was added to P10 (P1OH50); and P50 was added to H10 (H10P50). Exercise duration, after handgrip was combined with plantar flexion (P10H50), was shorter than that of H50, although the exercise duration of HIOP50 was not significantly different from P50. No significant difference was found between the difference from rest in oxygen uptake (
O2) during H10P50 and the sum of
O2 during H10 and P50. Also, the differences from rest in forearm blood flow ( FBF) and calf blood flow ( CBF) during H10P50 were not significantly different from FBF in H10 and from CBF in P50. In contrast,
O2 in P10H50 was lower than the sum of
O2 in P10 and H50 (P < 0.05), and J FBF in P10H50 was lower than that in H50 (P < 0.05) , while CBF was not significantly different between P1OH50 and P10. The changes in heart rate from rest (d HR) during the combined exercises were lower than the sums of HR in the corresponding single exercises (P < 0.05). These results demonstrated an inhibitory summation of several cardiorespiratory responses to combined exercise resulting in a reduction in exercise performance which would seem to occur easily when upperlimb exercise is added to lower limb exercise. 相似文献
95.
目的:探讨子宫下段剖宫产术不缝合腹膜对手术后效果影响。方法:对2000年7月~2001年7月在我院行改良式腹壁横切口子宫下段剖宫产168例,分成缝合腹膜组与不缝合腹膜组,在手术时间、术后镇痛药使用、肛门排气时间、术后发热、术后切口愈合方面进行观察和总结。结果:不缝合腹膜组在手术后发热,腹壁切口延期愈合方面与缝合腹膜组差异无显著性,在手术时间、术后肛门排气时间、术后镇痛药使用上比缝合腹膜组少。结论:施行子宫下段剖宫产,不缝合腹膜具有手术时间短、术后排气早、疼痛轻等优点,不会增加腹腔脏器粘连。 相似文献
96.
97.
乳腺癌根治术加放射治疗后上肢并发症的临床分析 总被引:5,自引:0,他引:5
目的了解乳腺癌根治手术加放射治疗患者上肢并发症的发病情况及其影响因素。方法对于接受根治或改良根治术后加放射治疗且放射治疗后已超过1年(中位数2.8年)的74例乳腺癌患者,从症状和体征两个方面进行了观测,并应用多因素回归分析相关的发病因素。结果患者上肢水肿的发生率在症状和体征检查中均约为50%,肩关节功能下降分别为49%和58%,患者年龄和全腋窝照射是发生上肢水肿与肩关节运动障碍的独立影响因素。结论上肢水肿和肩关节运动障碍是乳腺癌根治性手术加放射治疗后较常见的并发症,腋窝处理中减少正常组织的损伤以预防或降低其发生率,应该予以高度重视。 相似文献
98.
血栓闭塞性脉管炎病人血清中红细胞免疫调节因子的研究 总被引:1,自引:0,他引:1
为了探讨血栓闭塞性脉管炎病人血清中红细胞免疫调节因子对红细胞免疫功能的影响,测定了30例TAO病人红细胞免疫附促进因子花环率和红细胞免疫粘附抑制因子花环率。结果表显示:TAO组RFERR明显降低,RFIRR明显为高,与对照组比较有显著差异。 相似文献
99.
100.