全文获取类型
收费全文 | 237689篇 |
免费 | 30721篇 |
国内免费 | 9355篇 |
专业分类
耳鼻咽喉 | 1712篇 |
儿科学 | 2017篇 |
妇产科学 | 5248篇 |
基础医学 | 17020篇 |
口腔科学 | 2180篇 |
临床医学 | 20507篇 |
内科学 | 29648篇 |
皮肤病学 | 1485篇 |
神经病学 | 916篇 |
特种医学 | 8450篇 |
外国民族医学 | 253篇 |
外科学 | 36209篇 |
综合类 | 29880篇 |
现状与发展 | 38篇 |
一般理论 | 3篇 |
预防医学 | 11469篇 |
眼科学 | 115篇 |
药学 | 16906篇 |
147篇 | |
中国医学 | 5962篇 |
肿瘤学 | 87600篇 |
出版年
2024年 | 734篇 |
2023年 | 4911篇 |
2022年 | 9727篇 |
2021年 | 12474篇 |
2020年 | 11572篇 |
2019年 | 10324篇 |
2018年 | 10022篇 |
2017年 | 10318篇 |
2016年 | 11223篇 |
2015年 | 13068篇 |
2014年 | 19201篇 |
2013年 | 18639篇 |
2012年 | 15504篇 |
2011年 | 15761篇 |
2010年 | 11889篇 |
2009年 | 12127篇 |
2008年 | 12439篇 |
2007年 | 11639篇 |
2006年 | 10486篇 |
2005年 | 8495篇 |
2004年 | 6881篇 |
2003年 | 5755篇 |
2002年 | 4924篇 |
2001年 | 4475篇 |
2000年 | 3736篇 |
1999年 | 3133篇 |
1998年 | 2658篇 |
1997年 | 2373篇 |
1996年 | 1910篇 |
1995年 | 1794篇 |
1994年 | 1530篇 |
1993年 | 1157篇 |
1992年 | 1014篇 |
1991年 | 894篇 |
1990年 | 675篇 |
1989年 | 629篇 |
1988年 | 537篇 |
1987年 | 444篇 |
1986年 | 348篇 |
1985年 | 442篇 |
1984年 | 350篇 |
1983年 | 228篇 |
1982年 | 253篇 |
1981年 | 243篇 |
1980年 | 202篇 |
1979年 | 143篇 |
1978年 | 120篇 |
1977年 | 93篇 |
1976年 | 84篇 |
1975年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Arlene S. King William J. Threlfall Pierre R. Band Richard P. Gallagher 《American journal of industrial medicine》1994,26(1):125-132
The mortality profile of female nurses and teachers in British Columbia (BC) was examined using age-standardized proportional mortality ratios (PMRs) calculated for the period 1950–1984. Lowered overall mortality among nurses was seen for degenerative heart disease and for cerebrovascular accidents. Significantly elevated PMR values were observed for cancer of the breast and ovary in nurses of age 20–65 years. PMRs were significantly elevated for cancer of the pancreas and leukemia among those age 20 years and older. Elevated values were also observed for motor vehicle accidents and suicide among nurses in both age groups. Lower than expected mortality from degenerative heart disease and cerebrovascular accidents was seen in working age teachers (age 20–65 years). However, elevated PMRs were detected for carcinoma of the colon, breast, endometrium, brain, and melanoma. Among those 20 years and over, significantly elevated PMRs were also observed for cancers of the ovary and other digestive organs. Elevated PMRs were found for motor vehicle and aircraft accidents. Mortality from cirrhosis of the liver was lower than anticipated in both teachers and nurses. A number of significant PMRs declined when deaths of “homemakers” were withdrawn from the comparison group used to generate PMR values, suggesting that risk of death from various causes among women working outside the home differ from those seen in women who are predominantly in the home. 相似文献
992.
Siblings of a child with cancer 总被引:3,自引:0,他引:3
Summary A total of 21 healthy siblings were interviewed about their experiences when a brother or sister is diagnosed with cancer. Information about the illness, opinions about who should inform siblings, social support, specific worries and worst memories were studied, as well as perceptions of any differences in the way they were treated by their parents. A short General Impact Scale was developed to assess the extent to which the siblings felt their lives had been disrupted by the illness. Results on these measures were compared with scores on four dimensions of the Sibling Perception Questionnaire (Carpenter & Sahler 1991). Siblings who reported some positive effects as a consequence of the illness (they had become more empathic toward others, or valued life more) perceived their interpersonal relations to be more negatively affected, i.e. there were greater difficulties in their relationships with others especially their parents. Higher scores on communication were related to less of an impact of the illness on life generally. However, these siblings also reported heightened concerns that their brother or sister might die. The data suggested that siblings should have opportunities to talk about implications of the disease, especially worries about death, and more efforts should be made to prepare siblings for visits to hospital and seeing the sick child. 相似文献
993.
Xianghua Zhang Fumio Tsukuda Norihito Yamamoto Ikumasa Takenaka 《International journal of urology》1997,4(5):519-521
Brain metastases from prostate cancer are rare in postmortem examinations, and even rarer in clinical series. We report an unusual case of brain metastasis from prostate cancer confirmed by antemortem diagnosis in a 72-year-old man. The metastatic brain tumor was surgically resected and the patient was kept stable for more than 19 months after diagnosis of the brain metastasis. 相似文献
994.
Isao Kurosaki Kazuhiro Tsukada Hidenori Ueki Akira Ohya Katsuyoshi Hatakeyama 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(1):131-134
We report a case of advanced gallbladder cancer in a 37-year-old man who presented in June 1993 with malignant obstructive jaundice. After percutaneous transhepatic biliary drainage and several diagnostic imaging examinations, the patient underwent laparotomy under a diagnosis of extremely advanced gallbladder cancer involving the confluence of the hepatic ducts. The tumor, however, was judged to be unresectable because of its massive spread into the liver along Glisson's sheath, and because of histologically proven peritoneal dissemination. After exploratory laparotomy, one course of anticancer chemotherapy (cisplatin, 100 mg/body IV, on day 1, and 5-fluorouracil, 1000 mg/body, on days 1–5, by continuous infusion) was administered and the completely obstructed hepatic duct was dramatically re-canalized. Four courses of chemotherapy were administered over a 16-month period until jaundice recurred. For these 16 months, the patient's quality of life was well maintained without biliary drainage. He died of increased peritoneal dissemination approximately 2 years after the first course of anticancer chemotherapy. 相似文献
995.
Kazuro Sugi Kouichi Nawata Kazuhiro Ueda Yoshikazu Kaneda Sumihiko Nawata Atsunori Oga Kensuke Esato 《Surgery today》1997,27(7):666-668
We report herein the case of a 70-year-old man in whom a chest wall implantation of adenocarcinoma of the lung at the drainage
tube site was found 4 months after a right lower lobectomy with mediastinal lymph node dissection had been performed for adenocarcinoma
of the right lower lobe. The lesion was successfully treated by tumor extirpation. We believe that tumor seeding to the chest
wall occurred at the time of thoracotomy. To prevent such tumor seeding, the pleural cavity should be washed out routinely
with a massive volume of physiological saline solution prior to closure of the chest wall. 相似文献
996.
L. Simonato J. J. Moulin B. Javelaud G. Ferro P. Wild R. Winkelmann R. Saracci 《American journal of industrial medicine》1994,25(5):625-633
A historical mortality study of a cohort of employees of a gold mining and refining company was carried out in Salsigne, France. A major goal of the study was to investigate the relationship between lung cancer mortality and exposure to arsenic, radon, silica, and other contaminants of the working environment. A twofold excess of lung cancer was found both among miners and smelters, mainly concentrated among workers who had experienced exposure to past levels of arsenic, radon, and silica. The consistency of the results in the mine and the refinery are suggestive of a carcinogenic risk from both soluble and insoluble arsenic, although the potential role of other factors cannot be dismissed. © 1994 Wiley-Liss, Inc. 相似文献
997.
肝移植术后脑病的发病因素及防治 总被引:1,自引:0,他引:1
目的探讨肝移植术后脑病的原因及防治措施。方法回顾性分析185例肝移植患者的临床资料,将术后出现脑病的患者作为观察组,与对照组进行比较,分析发生脑病的原因,并总结其防治经验。结果肝移植术后出现脑病39例,占21.1%。脑病的发生与患者的术前Ch ild分级、有无肝性脑病史、术中的出血量、术后ICU天数及术后是否出现早期肝功能不良等因素显著相关,而与免疫抑制剂的血药浓度无显著相关性。结论肝移植术后脑病的发生是多因素的,通过合理的治疗,其预后良好。 相似文献
998.
HBV DNA及HBxDNA亚片段在肝癌细胞内的整合及作用 总被引:13,自引:0,他引:13
为探讨HBVDNA及其亚基因片段HBxDN在肝细胞肝癌(HCC)中整合特点用机制,制备了地高辛标记的3.2kbHBVDNA全基因及0.59kbHBVDNA/BamHI,BglⅡBHxDNA亚基因探针。点杂交、原位杂交及Southern杂交检测HBVDNA的存在情况,筛选HBVDNA纯整合标本,以HBxDNA探针检测HBxDNA在HCC染色体的整合。结果显示HBVDNA在肝细胞内以核型为主(70%) 相似文献
999.
Nihal Altan Yu Chen Melvin Schindler Sanford M. Simon 《The Journal of experimental medicine》1998,187(10):1583-1598
Multidrug resistance (MDR) is a significant problem in the treatment of cancer. Chemotherapeutic drugs distribute through the cyto- and nucleoplasm of drug-sensitive cells but are excluded from the nucleus in drug-resistant cells, concentrating in cytoplasmic organelles. Weak base chemotherapeutic drugs (e.g., anthracyclines and vinca alkaloids) should concentrate in acidic organelles. This report presents a quantification of the pH for identified compartments of the MCF-7 human breast tumor cell line and demonstrates that (a) the chemotherapeutic Adriamycin concentrates in acidified organelles of drug-resistant but not drug-sensitive cells; (b) the lysosomes and recycling endosomes are not acidified in drug-sensitive cells; (c) the cytosol of drug-sensitive cells is 0.4 pH units more acidic than the cytosol of resistant cells; and (d) disrupting the acidification of the organelles of resistant cells with monensin, bafilomycin A1, or concanamycin A is sufficient to change the Adriamycin distribution to that found in drug-sensitive cells, rendering the cell vulnerable once again to chemotherapy. These results suggest that acidification of organelles is causally related to drug resistance and is consistent with the hypothesis that sequestration of drugs in acidic organelles and subsequent extrusion from the cell through the secretory pathways contribute to chemotherapeutic resistance. 相似文献
1000.
《Pathology international》1997,47(11):809-811
The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology reporting of common malignant tumors. The recommendations for carcinoma of the larynx are reported herein. 相似文献