全文获取类型
收费全文 | 238034篇 |
免费 | 30360篇 |
国内免费 | 9425篇 |
专业分类
耳鼻咽喉 | 1712篇 |
儿科学 | 2018篇 |
妇产科学 | 5248篇 |
基础医学 | 17024篇 |
口腔科学 | 2180篇 |
临床医学 | 20536篇 |
内科学 | 29650篇 |
皮肤病学 | 1485篇 |
神经病学 | 916篇 |
特种医学 | 8450篇 |
外国民族医学 | 253篇 |
外科学 | 36211篇 |
综合类 | 29886篇 |
现状与发展 | 38篇 |
一般理论 | 3篇 |
预防医学 | 11474篇 |
眼科学 | 115篇 |
药学 | 16907篇 |
149篇 | |
中国医学 | 5962篇 |
肿瘤学 | 87602篇 |
出版年
2024年 | 750篇 |
2023年 | 4919篇 |
2022年 | 9730篇 |
2021年 | 12489篇 |
2020年 | 11574篇 |
2019年 | 10332篇 |
2018年 | 10022篇 |
2017年 | 10318篇 |
2016年 | 11223篇 |
2015年 | 13068篇 |
2014年 | 19203篇 |
2013年 | 18639篇 |
2012年 | 15504篇 |
2011年 | 15761篇 |
2010年 | 11889篇 |
2009年 | 12127篇 |
2008年 | 12439篇 |
2007年 | 11639篇 |
2006年 | 10486篇 |
2005年 | 8495篇 |
2004年 | 6881篇 |
2003年 | 5755篇 |
2002年 | 4924篇 |
2001年 | 4475篇 |
2000年 | 3736篇 |
1999年 | 3133篇 |
1998年 | 2658篇 |
1997年 | 2373篇 |
1996年 | 1910篇 |
1995年 | 1794篇 |
1994年 | 1530篇 |
1993年 | 1157篇 |
1992年 | 1014篇 |
1991年 | 894篇 |
1990年 | 675篇 |
1989年 | 629篇 |
1988年 | 537篇 |
1987年 | 444篇 |
1986年 | 348篇 |
1985年 | 442篇 |
1984年 | 350篇 |
1983年 | 228篇 |
1982年 | 253篇 |
1981年 | 243篇 |
1980年 | 202篇 |
1979年 | 143篇 |
1978年 | 120篇 |
1977年 | 93篇 |
1976年 | 84篇 |
1975年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
SUNG-GOO CHANG CHUL-SOO KIM SEUNG HYUN JEON YOUN-WHA KIM BO YOUL CHOI 《International journal of urology》2006,13(2):122-126
AIM: To evaluate the cause of elevated prostate-specific antigen (PSA) in patients with transrectal needle biopsy negative for prostate cancer. METHODS: Serum PSA concentration, prostate volume, and pathologic findings were examined in 223 patients with negative biopsy for prostate cancer. The degree of prostate inflammation was determined by the extent and degree of inflammation shown by biopsy specimens and is expressed as an inflammation score (range: 0-36). RESULTS: A significant correlation was found between PSA concentration and prostate total volume (P=0.0001). Prostate chronic inflammation showed no correlation with PSA concentration (P=0.485, F=0.488). After allocating patients to normal PSA (4 ng/mL) groups, we found that serum PSA concentrations in both groups were predominantly affected by prostate total volume. CONCLUSIONS: An increase in prostate volume appears to be the major contributor to a high serum PSA concentration in patients with negative biopsy for prostate cancer. However, in contrast to previous reports, there was no correlation between the degree of prostate chronic inflammation and serum PSA concentrations. 相似文献
83.
EDTA-induced urothelial cell shedding for the treatment of superficial bladder cancer in the mouse 总被引:3,自引:0,他引:3
OFER NATIV EILATA DALAL GUY HIDAS MOSHE ARONSON 《International journal of urology》2006,13(10):1344-1346
AIM: The aim of this study was to determine the effect of intravesical EDTA instillation on the development of intravesically implanted tumor cells in normal mice. METHODS: The mouse bladder tumor (MBT-2) model was used in female C3H/eb mice to evaluate the amount of normal urothelial cell shedding, and the degree of tumor growth inhibition following intravesical EDTA instillation in comparison with phosphate-buffered saline (PBS) instillation. RESULTS: At 1 h after instillation, the number of urothelial cells aspirated was 500-1000 per PBS-treated mouse and 10,000-20,000 per EDTA-treated mouse (P < 0.00001). The bladder weight, which reflected the effect of the agent on the tumor, was similar in the untreated and PBS-treated mice (105.46 +/- 46 mg and 106.2 +/- 50 mg, respectively). It was significantly lower in the EDTA-treated mice (80.4 +/- 42 mg) (P = 0.0045). CONCLUSIONS: Intravesical administration of EDTA results in significant normal and neoplastic urothelial cell shedding. Intravesical irrigation with EDTA may prevent adherence of the malignant cells to the bladder wall following tumor resection. 相似文献
84.
The case of a 75-year-old man with three synchronous carcinomas of the lung (large cell carcinoma, adenocarcinoma, and small cell carcinoma) is reported. This is the eighth well-documented case report in the literature; however, our case is the first to be reported with the newly described histological combination. 相似文献
85.
Jean de Ville de Goyet Raymond Reding Viktoria Hausleithner Jan Lerut Jean-Bernard Otte 《Transplant international》1995,8(4):280-285
This paper describes a quick procedure for cadaveric liver graft retrieval during multiple organ harvesting. The technique is based on minimal preliminary dissection, absence of in situ direct portal perfusion, and en bloc removal of the liver and pancreas, with an aortic patch encompassing the coeliac trunk and superior mesenteric artery. The results of 110 pediatric liver transplantations with 109 organs harvested using this technique are reported. There were no graft harvesting injuries. The liver graft primary nonfunction rate was 4.5% (5/110). The 3-month retransplantation rate was 10%. The actual patient survival rates were 93% at 3 months and 90% at 1 year; actual graft survival rates were 85.5% and 78%, respectively. The technique described was at least as safe as conventional procedures. A major advantage of the procedure is its flexibility, which allows for the easily combined procurement of other organs (whole pancreas and intestine). 相似文献
86.
本文应用核苷掺入技术及电镜观察首次证实雷公藤内酯对人胃癌细胞株 FGC_(85)的杀伤作用。用药早期,细胞数,分裂指数及 DNA,RNA 合成无明显变化,但出现核仁脱粒及核仁破碎等变化;晚期,电镜观察发现细胞以凋落方式死亡,药物主要作用于间期细胞,其杀伤机构的始动环节可能与核酸代谢障碍无关。 相似文献
87.
88.
Hexachlorobenzene (HCB) is still frequently found at elevated levels in human adipose tissue and breast milk. As intoxication
with HCB causes neurological disturbance in human beings, the purpose of the present study was to examine neurobehavioral
functions in rats after pre- and postnatal exposure. Female rats were fed diets with 0, 4, 8, or 16 mg HCB/kg diet. Exposure
started 90 days prior to mating and was continued throughout mating, gestation, and lactation. Thereafter, the offspring were
given the same diets as their respective mothers. HCB levels were determined in the brain, the liver, and in the adipose tissue
from virgin rats, dams, and the offspring. Concentrations on a lipid basis were found to decline in the order adipose>liver>brain.
The exposure levels chosen did not cause gross toxic effects in dams or offspring. There were dose-related increases in liver-to-body-weight
ratios in exposed dams, but not in unmated females treated alike. Behavioral testing was conducted in the offspring. Examination
of open-field activity on PND 21, and of active avoidance learning on PND 90 failed to reveal significant differences between
groups. Training of operant behavior started at the age of 150 days in the offspring from the control, the 8-mg group, and
the 16-mg group. Animals were trained on a fixed interval schedule of 1 min (FI-1). On this schedule, responses were reinforced
by a food pellet every time 1 min had elapsed after the preceding reinforcement. There were dose-dependent reductions in the
post-reinforcement pause, e.g. the time between each reinforcement and the first reaction emitted after it. In addition, the
index of curvature, which describes the efficiency of performance on the FI-1 schedule, was decreased in a dose-dependent
fashion.
Received: 12 April 1994 / Accepted: 26 June 1995 相似文献
89.
Dr. J. Tajti MD PhD ; Dr. K. Sas MD ; Dr. D. Szok MD ; Dr. E. Vörös MD ; Dr. L. Vécsei MD DSc 《Headache》1996,36(4):259-260
We report on a patient with clusterlike headache and multiple brain metastases of lung cancer. Initially, cluster headache was suggested clinically by characteristic symptoms without any focal central nervous system signs. However, magnetic resonance imaging demonstrated multiple brain metastases. It is possible that tumor necrosis factor may have played a role in initiating the clusterlike headache. 相似文献
90.
G. Rennert A. Tamir L. Katz R. Steinitz L. Epstein 《European journal of epidemiology》1988,4(4):461-469
The magnitude and dynamics of lung cancer incidence in Jews and Arabs in Israel between the years 1962 and 1982 were studied. In general, age-standardized incidence rates increased consistently between the years 1962 and 1976 among Jewish (24% increase) and Arab (39%) males, and to a lesser degree among Jewish females (15%). Arab females had the highest (77%) increase. From 1977 to 1982 a general decrease in incidence rates, which was largest among Arab males (19%) and females (15%), was noted. Rates among Jewish males are currently 26% higher than among Arab males, and are 162% higher among Jewish females than in Arab females. Lung cancer rates in both males and females in Istrael (Jews and Arabs) are lower than in most developed countries in the world. Among the possible reasons are differences in the population risk factors profile, availability of health care and the level of diagnosis and ascertainment of cases. 相似文献