姜春华截喘方加减治疗支气管哮喘急性发作37例

目的观察姜春华截喘方加减治疗支气管哮喘急性发作的疗效。方法将67例患者随机分为治疗组37例（常规西药加姜春华截喘方加减）和对照组30例（常规西药）。2周为1个疗程,共观察2个疗程。结果治疗组总有效率91.89%,对照组总有效率73.33%,差异有显著性意义（P〈0.05）。结论姜春华截喘方配合常规西药治疗支气管哮喘急性发作优于单纯常规西药治疗。     

Synthesis and Evaluation of a Novel Small-molecule Compound as an Anticancer Inhibitor of CD147

Objective Cancer is a serious threat to human health. Despite extensive research on cancer treatment,there is a growing demand for new therapies. CD147 is widely involved in tumor development, but it is unclear whether cancer cell malignancy is affected by CD147 expression level. The first compound(AC-73) targeting CD147 could only act on advanced tumors and inhibit metastasis. Therefore, new compounds with better anticancer activity should be explored.Methods Wst-1 assays were used to confirm the effect of novel compounds on proliferation.Apoptosis tests were used to evaluate their proapoptotic capacity. A nude mouse model was used to demonstrate in vivo anticancer activity and safety of the compounds. Western blots were used to suggest a molecule mechanism.Results There is a positive correlation between CD147 expression and tumor cell proliferation. A new compound, HA-08, was synthesized and proved to be more active than AC-73. HA-08 could inhibit cancer cell viability and promote cancer cell apoptosis both in vitro and in vivo. HA-08 induces cancer apoptosis, mainly by disrupting the CD147-CD44 interaction and then down-regulating the JAK/STAT3/Bcl-2 signaling pathway.Conclusion Our results have clarified the tumor specificity of CD147 and its drug target characteristics.The biological profile of HA-08 suggests that this compound could be developed as a potential anticancer agent.     

蒋益兰教授治疗恶性肿瘤骨转移经验

骨转移是多数晚期恶性肿瘤患者不可避免的一个病程阶段,发病率逐年升高,伴有的疼痛、压迫症状严重影响患者生活质量。蒋教授长期临证观察,认为骨转移的发生以脏腑亏虚为本,尤以脾肾亏虚为主; 癌毒为基本病因; 癌毒走窜,胶结于骨,阻滞气机,则常见寒凝、瘀、痰等实邪之标。临床治疗当以扶正祛邪、辨证与辨病结合为治疗原则,多以补肾健脾、散寒通滞、祛瘀化痰为法,配合虫类药物攻除癌毒,佐以引经药物使药至病所,内外治结合以提高疗效。现从治本治标、辨证与辨病、虫类药物运用、引经药物使用、外治联合增效等多方面、立体地阐述了蒋益兰教授防治恶性肿瘤骨转移经验,供临证参考。     

姜良铎应用桂枝加厚朴杏子汤治疗喘证经验

总结姜良铎教授应用桂枝加厚朴杏子汤治疗喘证的临证经验。从多维度、多层次进行分析,明确喘证的主导病机、初始病机及潜在病机,整体把握患者当前状态,从状态论治喘证。临证运用桂枝加厚朴杏子汤加减以祛邪通补平喘,同时强调外感以内伤为基础,擅用角药或对药平补通补,兼以调平脏腑功能关系,收效颇佳。