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71.
Tsukumi TONDOKORO Akinori NAKATA Yasumasa OTSUKA Nobuyuki YANAGIHARA Ayumi ANAN Hiromi KODAMA Noriaki SATOH 《Industrial health》2021,59(2):128
Although participatory workplace improvement programs are known to provide favorable effects on high stress occupations like nursing, no studies have confirmed its effect using biomarkers. The aim of this study was to determine whether a participatory workplace improvement program would decrease stress-related symptoms as evaluated by biomarkers and self-reported stress among hospital nurses. Three actions to alleviate job stress, which were determined through focus group interviews and voting, were undertaken for two months. A total of 31 female Japanese nurses underwent measurement of inflammatory markers, autonomic nervous activity (ANA), and perceived job stress (PJS) at three-time points; before the program (T1), within a week after the completion of the program (T2), and three months after the program (T3). A series of inflammatory markers (Interferon-γ, Interleukin (IL)-6, and IL-12/23p40) decreased significantly at T2, and IL-12/23p40 and IL-15 significantly decreased at T3 compared to T1, while ANA and PJS remained unchanged. Our participatory program exerted beneficial effects in reducing inflammatory responses, but not for ANA and PJS. Further investigations with a better study design, i.e., a randomized controlled trial, and a larger sample size are warranted to determine what exerted beneficial effects on inflammatory markers and why other outcomes remained unchanged. 相似文献
72.
Fang Liu Deming Li Xinjing Wang Yuan Cui 《International journal of food sciences and nutrition》2021,72(1):14-25
AbstractWhether polyphenols could ameliorate inflammatory bowel disease (IBD) is still conflicting. To explore the efficacy of polyphenols as an adjuvant therapy for IBD, we conducted this systematic review and meta-analysis. Literature search was performed using PubMed, Web of Science, Scopus and Cochrane databases. Finally, 12 randomized controlled trials (RCTs) were included. In contrast to control group, curcumin treatment significantly improved clinical remission in intention-to-treat (ITT) (OR = 3.36, 95% CI: 1.09–10.37) and per-protocol (PP) analysis (OR = 5.13, 95% CI: 1.84–14.27). Meanwhile, curcumin could significantly ameliorate endoscopic remission (OR = 5.69, 95% CI: 1.28–25.27) and clinical response (OR = 4.69, 95% CI: 1.03–21.47) in PP analysis. Heterogeneity was present across the studies. In conclusions, polyphenols might be an effective adjuvant treatment for ameliorating IBD. Considering the relatively few studies included in our present study, further clinical trials are required to verify the effects of polyphenols on IBD. 相似文献
73.
TL1A是肿瘤坏死因子超家族的一个新亚群。通过与受体DR3和DcR3/TR6的结合,既可诱导细胞凋亡,也能活化NF-ΚB。在淋巴细胞、单核细胞/巨噬细胞的活化和增殖,炎症反应的调节、机体的免疫应答以及动脉粥样硬化、炎症性肠病等疾病的发生、发展中起重要作用。 相似文献
74.
Karel Geboes Gert De Hertogh Marie-Astrid Van Caillie Peter Van Eyken 《Current Diagnostic Pathology》2007,13(6):479-489
Gastrointestinal polyps are common lesions that usually present singly or in small numbers. Although the term ‘multiple colorectal polyposis’ was originally applied to patients carrying at least 100 large intestinal adenomas, it has subsequently become broadened to include patients carrying multiple polyps regardless of their nature. Most of the non-adenomatous polyposis syndromes are hereditary. They can be classified according to the dominant type of polyp, their distribution in the gastrointestinal tract and their potential for the development of gastrointestinal cancers. This review summarises their main clinical, genetic and histopathological features. 相似文献
75.
R. H. Ming D. Atluru C. W. Spellman T. Imir J. S. Goodwin R. G. Strickland 《Journal of clinical immunology》1987,7(1):59-63
The interleukin-2 pathway is essential for the normal immune response to antigen stimulation; we have examined the possibility that this may underlie abnormal peripheral blood lymphocyte immunoregulatory function that has been observed in patients with inflammatory bowel disease. We studied 11 patients with Crohn's disease and 5 with ulcerative colitis, all with quiescent disease activity. Peripheral blood mononuclear cells were isolated from these patients and from healthy age- and sex-matched controls. Interleukin-2 production after mitogen and phorbol-myristate acetate stimulation was similar in both groups: 381±71 (mean ± SE) U/ml by control cells and 451±70 by patient cells. Interleukin-2 receptor generation was also measured pre- and poststimulation by labeling with anti-Tac antibody. This was 10.45±1 and 69.95±3.85% for control cells and 11.41±1.38 and 60.9±4.25% for patients cells. Finally, we examined the response of these cells to interleukin-2 stimulation by generating cells with direct cytotoxicity to51Cr-labeled Daudi-cell targets. Control cells caused 59.5±46%51Cr release, whereas patient cells caused 50.8±5.18% release. None of the above results achieved statistical significance. We conclude that the peripheral blood interleukin-2 pathway is normal in inactive inflammatory bowel disease. 相似文献
76.
77.
目的研究溃疡性结肠炎患者的炎性因子水平、肠道菌群分布及发病相关危险因素,为溃疡性结肠炎的防治工作提供科学依据。方法以2020年6月至2021年5月在文昌市某医院就诊的溃疡性结肠炎患者作为病例组,同时选取(按年龄相差0.5岁,性别相同招揽志愿者参与本研究)同期在该医院进行健康体检者作为对照组。所有研究对象进行问卷调查、肠道菌群检测及炎症因子检测,采用描述性分析方法对2组相关指标进行比较,并对溃疡性结肠炎发病影响因素进行单、多因素分析。结果共纳入溃疡性结肠炎病例(病例组)和健康体检者(对照组)各200例,男性各99例,女性各101例,病例组平均年龄(43.17±8.72)岁,对照组平均年龄(43.54±9.11)岁,2组的年龄、性别分布差异均无统计学意义(均P>0.05)。病例组主要检出的双歧杆菌、乳杆菌数量低于对照组,拟杆菌、肠杆菌、肠球菌、梭杆菌数量高于对照组(均P<0.01)。病例组除白细胞介素(IL)-4水平低于对照组,IL-6、IL-17、IL-23以及肿瘤坏死因子-α(TNF-α)均高于对照组(均P<0.01)。饮酒(OR=3.526)、吸烟(OR=1.272)、饮食不洁(OR=4.592)、存在合并感染(OR=2.146)、情绪紧张(OR=3.919)均为溃疡性结肠炎发病的危险因素。结论溃疡性结肠炎患者肠道菌群种类、数量分布不平衡,血清炎症因子水平明显上升。良好的生活行为习惯以及积极地健康教育可降低溃疡性结肠炎的发生风险。 相似文献
78.
局部炎症反应与无细胞异种真皮基质移植物的降解吸收关系 总被引:2,自引:1,他引:2
目的 探讨不同方法制作的无细胞异种真皮基质(Xeno-ADM)移植物降解吸收与炎症反应之间的关系。方法 猪和兔断层中厚皮片经Trypsin和TritonX-100等脱细胞,分别制成Xe-no-ADM和异体ADM(Allo-ADM),再按不同的预处理因素进行分组:(1)戊二醛交联的Xeno-ADM(A)组;(2)网状交联的Xeno-ADM(B)组;(3)未交联的:Xeno-ADM(C)组,预先被Xeno-ADM蛋白致敏的兔皮下植入;(4)交联的Xeno-ADM(D)组;(5)Allo-ADM(E)组。每组80块ADM分别埋植于兔耳和背部皮下。结果在背部的移植物较耳部炎性反应和降解吸收明显,至术后32wk时,E组以外的其它组移植物解剖学和组织学结构消失,D组和A组炎症反应滞后,可见较多的异物巨细胞,各组ADM炎症反应与降解/吸收的程度依次为:C>B>D>A>E(P相似文献
79.
80.
针刺对胃癌术后早期肠内营养患者免疫功能的影响 总被引:2,自引:0,他引:2
目的 :研究胃癌根治术后行早期肠内营养患者配合相关耳—体穴针刺对机体免疫功能的影响。方法 :3 2例胃癌根治术患者均予等氮、等热量早期肠内营养 8天 (能全力 ,Nutricia提供 ) ,随机分为 2组 ,研究组 (n=16)同时配合相关耳—体穴针刺。两组患者手术前后均定期监测肝功能各项指标、外周血 T细胞亚群、免疫球蛋白、急性炎性反应指标及胃肠道功能恢复时间、并发症发生情况。结果 :两组均无手术并发症及营养支持代谢并发症发生。手术前后 AST、ACT、TBIL、AKP均无升高 ;与术前 (POD0 )比较 ,术后第 1天 (POD1)两组血浆白蛋白均明显下降 (P<0 .0 1) ,外周血 T细胞亚群CD4、CD4/ CD8及血浆球蛋白 Ig G、Ig M、Ig A均明显下降 (P<0 .0 1及 P<0 .0 5) ,而血浆急性炎性反应指标 (IL-6、PGE2 )均显著升高 (P<0 .0 1) ;至 POD8两组血浆白蛋白、外周血 T细胞亚群 CD4、CD4/CD8及血浆球蛋白 Ig G均有提高 ,与对照组比较 ,研究组升高更明显 (P<0 .0 5) ,而急性炎性反应指标 (IL-6、PGE2 )均有所下降 ,研究组下降更明显 (P<0 .0 5) ,同时 ,研究组肠功能恢复较快 ,对早期肠内喂养耐受性好。结论 :对胃癌根治术后行早期肠内喂养的患者予配合相关耳—体穴针刺 ,可有效地刺激机体免疫功能 ,缓解过度的急性炎性反应 ,促进 相似文献