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71.
Spartaco Bellomo 《Emerging infectious diseases》2005,11(6):985-987
72.
贯众提取液对革兰氏阳性球菌的抑菌作用 总被引:6,自引:0,他引:6
目的:了解贯众(Dryopteris crossirhizomz)不同提取液对革兰氏阳性球菌的抑菌作用。方法:分别用水以及3种不同pH值的70%乙醇为溶媒提取贯众干品以制备贯众提取液,利用打孔法和试管稀释法测定提取液对13种微生物的抑制效果。结果:每1ml含生药1g的贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是革兰氏阳性球菌如金黄色葡萄球菌和甲型溶血性链球菌等。对革兰氏阴性菌和真菌的抑制作用较弱,但对普通变形杆菌则有较强的抑制作用。不同pH值的抽提溶剂对药物的有效抑菌成份的提出效果不同,抽提溶剂pH越小,有效成份的提出效果越好。结论:贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是对革兰氏阳性球菌,而对革兰氏阴性菌和真菌的抑制作用则较弱。贯众的抗菌成份易溶于水,抽提效果随pH减小而增加。 相似文献
73.
Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment 总被引:4,自引:4,他引:0
Wu-chun Cao Catharina P. B. Van der Ploeg Anton P. Plaisier I. J. Sivera van der Sluijs J. Dik F. Habbema 《Tropical medicine & international health : TM & IH》1997,2(4):393-403
Summary The efficacy and safety of ivermectin in the treatment of filariasis due to Wuchereria bancrofti was assessed by a meta-analysis of the results from 15 published clinical trials. Seven hundred and forty-eight microfilaraemic patients were enrolled in 7 dose-finding and 8 comparative studies. Administered as a single dose, ivermectin induced nearly complete clearance of microfilariae from the blood from the first day to 30 days post-treatment, followed by gradual recurrence of microfilaraemia and increase in its intensity. Higher doses of ivermectin showed greater clearance effects and maintained lower microfilaraemia levels for a longer time. The adverse reactions caused by the drug were flu-like, transient, generally mild and well tolerated by patients. The frequency and intensity of adverse reactions were strongly associated with pretreatment microfilaria counts in the blood, but independent of dose. The findings of the meta-analysis suggest that ivermectin given at a single annual dose of 200 μg/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis. 相似文献
74.
75.
The effects of left- and right-sided hemispheric brain infarction on variability in circadian blood pressure and cardiovascular measures were investigated in 35 patients to test for asymmetry of the sympathetic consequences of stroke. No significant differences regarding age, size of infarction or extent and frequency of damage to the insular cortex could be detected between the two groups. Patients with right-sided infarction showed a significantly reduced circadian blood pressure variability [diastolic: -1% (95% CI -4 to 1) vs -6% (-9 to -2);P < 0.05] and a higher frequency of nocturnal blood pressure increase (47% vs 35%;P < 0.05) as compared with patients with left-sided infarction. Right-sided infarction was also associated with higher serum noradrenaline concentrations [546 pg/ml (95% CI 415–677) vs 405 pg/ml (266–544);P < 0.05], and ECG more frequently showed QT prolongation (53% vs 35%;P < 0.05) and cardiac arrhythmias (67% vs 20%;P < 0.005). However, irrespective of the hemisphere damaged, patients with insular infarction showed the most pronounced changes of these parameters. In addition, two patients with right-sided strokes (13%) involving the insula, but none with a left-sided infarction, developed myocardial infarction. These findings suggest lateralization of sympathetic activation with right-sided dominance for sympathetic effects following hemispheric stroke.Supported by the Friedrich-Schiedel-Stiftung 相似文献
76.
目的 分析经皮射频消融(PRFA)与手术切除治疗直径≤3 cm原发性小肝癌的疗效。方法 选取2015年1月—2017年6月兰州市第二人民医院收治的原发性小肝癌患者78例。将36例接受PRFA治疗的患者作为观察组,另外42例行手术切除的患者作为对照组。采用全自动生化分析仪检测血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)水平,电化学发光全自动免疫分析仪检测血清甲胎蛋白(AFP)水平。结果 观察组手术时间、术中出血量、住院时间均少于对照组(P <0.05);观察组治疗前后AST、ALT、TBIL、AFP的差值均高于对照组组(P <0.05)。两组术后并发症比较,差异无统计学意义(P>0.05);两组治疗后1、2、3、5年的生存率和复发率比较,差异均无统计学意义(P>0.05)。结论 与手术切除比较,PRFA治疗直径≤3 cm原发性小肝癌可缩短手术时间,减少术中出血量,促进肝功能恢复,但两者术后并发症发生率、生存率和复发率接近。 相似文献
77.
目的 比较改良尿道板重建卷管尿道成形术(又称Koyanagi术)与尿道板纵切卷管尿道成形术(TIP)在儿童尿道下裂中的临床疗效。方法 回顾性分析2018年1月—2021年10月甘肃省妇幼保健院收治的104例尿道下裂患儿的临床资料,其中53例患儿行改良Koyanagi术(研究组),51例患儿行TIP(对照组)。两组患儿术后均随访12个月。比较两组手术时间、术中出血量、术后疼痛及排尿功能、手术成功情况,对比两组术后并发症发生情况。结果 两组手术时间、术中出血量比较,差异均无统计学意义(P >0.05)。两组患儿术后4、12、24和48 h的FLACC评分比较,采用重复测量设计的方差分析,结果 ①不同时间点FLACC评分差异有统计学意义(F =10.871,P =0.000);②研究组与对照组FLACC评分差异无统计学意义(F =1.849,P =0.157);③研究组与对照组FLACC评分变化趋势差异无统计学意义(F =2.516,P =0.085)。两组患儿术后12个月的最大尿流率、平均尿流率、排尿量、尿流时间、手术成功率比较,差异均无统计学意义(P >0.05)。研究组术后总并发症发生率低于对照组(P <0.05)。结论 改良Koyanagi术与TIP治疗儿童尿道下裂疗效相近,均可获得满意效果,但改良Koyanagi术在降低术后并发症方面具有优势。 相似文献
78.
In many animal studies, acute treatment with the novel anxiolytic agent buspirone exhibits only minimal anxiolytic efficacy (i.e., increases in punished responding) when compared to benzodiazepines and barbiturates. The present studies examined the effects of acute pre-test challenges with buspirone in subjects receiving chronic post-test buspirone or saline treatments. Chronic post-test treatment with buspirone (4 mg/kg/day for 4 weeks, followed by 8 mg/kg/day for 12 weeks) did not significantly affect CSD behavior. Consistent with previous reports, acute pre-test administration of buspirone (0.125–2 mg/kg, IP) to subjects receiving chronic post-test saline treatment resulted in only a modest anti-conflict effect in the CSD paradigm (approximately ten shocks over control). In contrast, subjects chronically treated with buspirone exhibited a dramatically greater anti-conflict effect following acute challenge with buspirone (up to 40 shocks over control). These data are consistent with the hypothesis that the full anxiolytic efficacy of buspirone requires repeated administration. 相似文献
79.
Fifty-eight patients with well-documented history of seasonal rhinoconjunctivitis caused by grass pollens were allocated randomly on a double-blind basis to receive either sublingual therapy with a solution of purified, standardized allergen preparation (Stallergenes) or a matched placebo for 17 weeks. The assessment of the effect of oral immunotherapy, done with drops of five-grass allergen extract, was on the clinical symptoms and on the medication score of the authorized rescue treatments. The actively treated patients had significantly (P<0.05 to P<0.01) fewer symptoms of rhinitis (sneezing and rhinorrhea) and of conjunctivitis (redness and tears) during the pollen season than the placebo group. Consumption of nasal solution of sodium cromoglycate and of betamethasone and dexchlorpheniramine was significantly less in the desensitized group (P<0.01). Side-effects were negligible. This study concludes that perlingual immunotherapy with grass pollen extract in grass-pollen-sensitive seasonal hay fever and conjunctivitis patients is effective, easy to perform, inexpensive, and safe. 相似文献
80.
张维林 《生物医学工程与临床》2003,7(4):226-227
目的 制作具有升降调节功能的床边屏蔽辅助板 ,防范等高散射线 ,增加近台操作的安全防护系数 ,使腹部以下透射剂量率下降至最小程度。方法 制作带有内铅层的空腔竖立直板 ,内层铅板可在竖立直板空腔内上 下移动 ,满足不同的床边屏蔽高度。结果 屏蔽床边位屏蔽辐射实验测定值与市防站的实际测定值分别为 2 .5 0× 10 8μGy/h和 2 .5 8× 10 8μGy/h,符合最优化设计及国家标准要求。结论 本研究研制的床边屏蔽辅助板具有较高的临床实用价值 相似文献