Safety and efficacy of traditional Chinese medicine,Qiaoshao formula,combined with dapoxetine in the treatment of premature ejaculation: An open-label,real-life,retrospective multicentre study in Chinese men

To evaluate the safety and efficacy of Chinese medicine, Qiaoshao formula combined with dapoxetine was used for the treatment of premature ejaculation in a real-life setting. Nine hundred and five males diagnosed with premature ejaculation were reviewed in this retrospective cohort study. We divided the patients into two groups: dapoxetine alone and Qiaoshao formula combined with dapoxetine according to actual interventions provided to patients in clinics. The perceived intravaginal ejaculation latency time and the premature ejaculation profile measures markedly improved in both groups. However, in men with severe premature ejaculation (baseline perceived intravaginal ejaculation latency time <1 min) and those with baseline age ≤30 years, the perceived intravaginal ejaculation latency time was slightly but significantly longer with combined therapy than with dapoxetine alone (p < .05). Therefore, combined therapy involving the Qiaoshao formula and dapoxetine proved to safe as well as effective for treating premature ejaculation while prolonging the perceived intravaginal ejaculation latency time, which significantly improved the overall satisfaction of the patient and likely that of the couple.     

Allergen-Specific IgE Antibodies against Antigenic Components in Cow Milk and Milk Substitutes

Crossed radioimmunoelectrophoresis (CRIE) was used to study the presence of serum IgE against antigenic components of cow milk in 21 selected milk-allergic patients. The amount of each IgE specificity was estimated by a scoring system. The milk-allergic children had mainly IgE against alpha-lactalbumin, beta-lactoglobulin, albumin and immunoglobulin, the four major proteins of bovine whey, as well as IgE against three casein components. A serum pool from 1000 normal adults had IgE against the same whey protein, but in smaller amounts, and no IgE against the casein components. Eight cow milk-based formulae, commonly used for infant feeding, and goat milk were studied by the same method. It was found that six of the milk substitutes did not differ significantly from cow milk in antibody binding, but the two hydrolysed casein products, Nutramigen and Pregestimil, consisted of such small molecules that the rabbit antisera could not precipitate the hydrolysed proteins in the gels on the CRIE plates. It was therefore not possible to study their IgE binding, if any, by this method.     

情景模拟联合口诀法对ICU实习护生心肺复苏培训的效果

目的 探讨情景模拟联合实训口诀法在ICU护生心肺复苏培训的效果.方法 将80名护生随机分为对照组与观察组各40名.对照组采用常规教学方法;观察组采用情景模拟联合实训口诀法进行心肺复苏培训.比较两组培训前后的理论、操作成绩,操作失误率,抢救时各项操作落实时间及观察组对教学方法的评价.结果 培训后观察组心肺复苏理论及操作考...     

和解聚散方对单侧输尿管梗阻肾间质纤维化大鼠细胞外基质表达的影响

目的:研究和解聚散方对单侧输尿管梗阻(unilateral ureteral obstruction,UUO)大鼠肾间质纤维化(renal interstitial fibrosis,RIF)、细胞外基质(extracellular matrix,ECM)、纤维连接蛋白(FN)和Ⅳ型胶原(Col Ⅳ)表达的影响.方法:...     

数据挖掘技术在方剂配伍中的研究现状及研究方法

本文分析了数据挖掘技术在中医药研究领域以及方剂配伍中的研究现状,在此基础上对方剂配伍规律中数据挖掘技术的技术路线及研究内容进行了探讨,重点提出了几点数据挖掘技术在方剂配伍规律的研究方向。     

补肾活血方对恒河猴PCO模型卵巢COX-1mRNA表达的影响

目的探讨补肾活血方对恒河猴多囊卵巢(PCO)模型卵巢局部环氧化酶-1(COX-1mRNA)表达的影响。方法选择健康育龄雌性恒河猴(6只)随机分为正常对照组、模型对照组、补肾活血方组;采用皮下注射丙酸睾丸酮(T)和绒毛膜促性腺激素(HCG)建立PCO模型,分别灌胃给予生理盐水、补肾活血方,采用原位杂交技术观察各组卵巢局部COX-1mRNA表达的变化。结果各组卵巢组织均可见COX-1基因表达的信号,以颗粒细胞表达最丰富;其中模型组卵泡膜细胞呈现异常高表达;补肾活血方组表达水平接近正常对照组。结论恒河猴PCO模型卵巢局部COX-1mRNA异常表达,可能与多囊卵巢综合征(PCOS)发病有关;补肾活血方有可能通过降低COX-1mRNA的表达而达到改善PCOS无排卵的状况。     

《小品方》方剂学成就初探

从《小品方》的方剂组成、治法、剂型及煎制、临床应用等几个方面初步探讨《小品方》的方剂学成就。《小品方》组方简单,加减化裁灵活,已经初具方剂学治法体系,体现了"八法"的治疗原则,同对剂型多样,重视煎制法对方剂疗效的影响,临床应用广泛。     

Longitudinal zinc balances in breast-fed and formula-fed infants

Longitudinal zinc (Zn) balance studies were performed under domestic conditions in term breast-fed (n = 10), term formula-fed (n = 5; Zn concentration in the formula: 4 mg/l) and preterm formula-fed (n = 3) infants during the first 17 weeks of life. Samples of milk, urine and feces were analyzed by atomic absorption spectrometry. The median daily Zn intake in breast-fed infants decreased from 0.592 (0.457-0.829) mg Zn/kg body weight to 0.151 (0.095-0.304) mg Zn/kg body weight in the first 17 weeks of life; comparable values for bottle-fed term infants were 0.58 (0.511-0.701) and 0.674 (0.529-0.731) mg Zn/kg body weight. The median percent retention of Zn intake was 27 (-60 to 81.4)% in breast-fed infants and 21.5 (-42 to 64)% in formula-fed infants. In view of the urinary and fecal Zn losses measured, a daily intake of 0.3-0.5 mg Zn/kg body weight is considered to be sufficient to ensure a Zn retention equivalent to breast-fed infants. This requires a Zn concentration of 2-3 mg/l of Zn depending on milk volume intake.     

Response to poliovirus immunization and type of feeding in babies of atopic families

The aim of the present study was to investigate the antibody response to oral poliovirus immunization, and to evaluate the infection morbidity in a group of infants with a positive family history of atopy who were soy-protein-formula fed during the first 6 months of life. We have selected and followed from birth to 4 yr, 107 babies, 18 of whom were exclusively soy-protein-formula fed during the first 6 months of life. All infants were seen at our clinic at the ages of 1, 3, 6, 9, and 12 months, and once-a-year afterwards. They regularly received the oral vaccine against polioviruses at the ages of 3, 5 and 12 months. At age 6, 12 and 24 months, poliovirus type 1, 2 and 3 antibodies were detected. There was no significant difference of seroconversion in the babies, breast, soy or breast and soy fed. Furthermore, no increase in infection morbidity was observed in the soy-protein-formula fed infants. Our data shows that soy-protein-formula feeding in the first 6 months of life does not induce any abnormal antibody response to the oral poliovirus vaccination, as well as no increase in infection morbidity.     

Selenium status of New Zealand infants fed either a selenium supplemented or a standard formula

Objective: New Zealand soils are deficient in the essential micronutrient, selenium. New Zealand infants have low selenium levels at birth and experience a further decline if fed cows milk based formula. This study examined the selenium status of infants fed with a new commercially available selenium supplemented formula.
Methodology Forty-four newborn infants, whose mothers wished to formula feed, were randomized in an open controlled trial to be fed a commercially available selenium supplemented cows milk formula (containing 17 μg Se/L) or an unsupplemented formula (containing 4.6 μg Se/L). Cord, 1 and 3 month blood samples were obtained for selenium status (plasma and red cell selenium and glutathione peroxidase) and thyroid function.
Results Mean plasma selenium and glutathione peroxidase values were significantly higher in supplemented than unsupplemented infants at 1 month (unpaired t -tests; P <0.0001 and P = 0.001 respectively) and 3 months ( P <0.0001 and P = 0.0005). Analysis within treatment groups between time points (paired t -tests) showed that selenium supplementation prevented the fall in plasma selenium from birth to 1 month seen in unsupplemented infants and was associated with a rise in levels between 1 and 3 months ( P = 0.002).
Conclusions Supplementing cows milk formula with selenium to replicate the levels found in breast milk is nutritionally sound. Feeding from a few days of age with a formula containing 17 μg Se/L in infants with low selenium status at birth is sufficient to cause a rise to 80% of adult levels at 3 months of age.